SB-616234-A (1-[6-(cis-3,5-dimethylpiperazin-1-yl)-2,3-dihydro-5-methoxyindol-1-yl]-1-[2′methyl-4′-(5-methyl-1,2,3-oxadiazol-3-yl)biphenyl-4-yl]methanone hydrochloride): A novel, potent and selective 5-HT1B receptor antagonist

Neuropharmacology

Volumn 50, Issue 8, 2006, Pages 984-990

  Scott, Claire ^a   Langmead, Christopher J ^a   Clarke, Kirsten L ^a   Wyman, Paul ^a   Smith, Paul W ^a   Starr, Kathryn R ^a   Dawson, Lee A ^a   Price, Gary W ^a   Hagan, James J ^a   Watson, Jeannette ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

5 HT1B receptor; Guinea pig; Human; Rat; SB 616234 A

Indexed keywords

1 [6 (3,5 DIMETHYLPIPERAZIN 1 YL) 2,3 DIHYDRO 5 METHOXYINDOL 1 YL] 1 [2' METHYL 4' (5 METHYL 1,2,3 OXADIAZOL 3 YL)BIPHENYL 4 YL]METHANONE; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); N [4 METHOXY 3 (4 METHYL 1 PIPERAZINYL)PHENYL] 3 METHYL 4 (4 PYRIDYL)BENZAMIDE; SB 616234A; SEROTONIN; SEROTONIN 1B ANTAGONIST; SEROTONIN 1B RECEPTOR; SULFUR 35; TRITIUM; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN MEMBRANE; BRAIN SLICE; CHO CELL; CONTROLLED STUDY; CORPUS STRIATUM; DOSE RESPONSE; DRUG ACTIVITY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG TARGETING; EX VIVO STUDY; FEMALE; GUINEA PIG; HUMAN; HUMAN CELL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SEROTONIN RELEASE;

ANALYSIS OF VARIANCE; ANIMALS; BINDING, COMPETITIVE; CEREBRAL CORTEX; CHO CELLS; CRICETINAE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ELECTRIC STIMULATION; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); GUINEA PIGS; HUMANS; INDOLES; MEMBRANE POTENTIALS; NEURONS; OXADIAZOLES; PATCH-CLAMP TECHNIQUES; PIPERAZINES; PROTEIN BINDING; RATS; RECEPTOR, SEROTONIN, 5-HT1B; SEROTONIN; SEROTONIN ANTAGONISTS; SULFUR ISOTOPES; TRITIUM;

EID: 33646938961     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2006.01.008     Document Type: Article

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