Effects of SAPK/JNK inhibitors on preimplantation mouse embryo development are influenced greatly by the amount of stress induced by the media

Molecular Human Reproduction

Volumn 12, Issue 4, 2006, Pages 217-224

  Xie, Y ^a   Puscheck, E E ^a   Rappolee, D A ^a,b  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis, brdU; Cell proliferation; N terminal Jun kinase (SAPK JNK), SAPK inhibitor D JNK1, TUNEL; Preimplantation embryos, embryo media, stress activated protein kinase

Indexed keywords

AMINO ACID; BROXURIDINE; POTASSIUM; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE INHIBITOR;

ANALYSIS OF VARIANCE; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL COUNT; CELL CYCLE ARREST; CELL CYCLE S PHASE; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; CORRELATION ANALYSIS; CULTURE MEDIUM; EMBRYO; EMBRYO CULTURE; EMBRYO DEVELOPMENT; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; GROWTH RETARDATION; HATCHING; MOUSE; MOUSE STRAIN; NICK END LABELING; NONHUMAN; PREIMPLANTATION EMBRYO; PRIORITY JOURNAL; STRESS;

ANIMALIA;

EID: 33646857516     PISSN: 13609947     EISSN: 14602407     Source Type: Journal    
DOI: 10.1093/molehr/gal021     Document Type: Article

References (36)

1. Bain J, McLauchlan H, Elliott M and Cohen P (2003) The specificities of protein kinase inhibitors: An update. Biochem J 371,199-204.
2. Barker DJ, Gluckman PD, Godfrey KM, Harding JE, Owens JA and Robinson, JS (1993). Fetal nutrition and cardiovascular disease in adult life. Lancet 341, 938-941.
3. Bennett BL, Sasaki DT, Murray BW, O'Leary EC, Sakata ST, Xu W, Leisten JC, Motiwala A, Pierce S, Satoh Y et al. (2001) SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase. Proc Natl Acad Sci USA 98, 13681-13686.
4. Bonny C, Nicod P and Waeber G (1998) IB1, a JIP-1-related nuclear protein present in insulin-secreting cells. J Biol Chem 273,1843-1846.
5. Bonny C, Oberson A, Negri S, Sauser C and Schorderet DF (2001) Cellpermeable peptide inhibitors of JNK: Novel blockers of beta-cell death. Diabetes 50,77-82.
6. Bonny C, Oberson A, Steinmann M, Schorderet DF, Nicod P and Waeber G (2000) IB1 reduces cytokine-induced apoptosis of insulin-secreting cells. J Biol Chem 275,16466-16472.
7. Brison DR and Leese HJ (1991). Energy metabolism in late preimplantation rat embryos. J Reprod Fertil 93,245-51.
8. Ecker DJ, Stein P, Xu Z, Williams CJ, Kopf GS, Bilker WB, Abel T and Schultz RM (2004) Long-term effects of culture of preimplantation mouse embryos on behavior. Proc Natl Acad Sci USA 101,1595-1600.
9. Fernandez-Gonzalez R, Moreira P, Bilbao A, Jimenez A, Perez-Crespo M, Ramirez MA, Rodriguez De Fonseca F, Pintado B and Gutierrez-Adan A (2004). Long-term effect of in vitro culture of mouse embryos with serum on mRNA expression of imprinting genes, development, and behavior. Proc Natl Acad Sci U S A 101,5880-5885.
10. Hogan B, Beddington R, Constantini F and Lacy B (2002). "Manipulating the mouse embryo, A laboratory manual." Cold Spring Harbor Laboratory, Cold Spring Harbor.
11. Ip YT and Davis RJ (1998). Signal transduction by the c-Jun N-terminal kinase (JNK) - from inflammation to development. Curr Opin Cell Biol 10,205-19.
12. Johnson MH (2005). The problematic in-vitro embryo in the age of epigenetics. Reprod Biomed Online 10 Suppl 1,88-96.
13. Joiakim A, Mathieu PA, Palermo C, Gasiewicz TA and Reiners JJ Jr (2003) The Jun N-terminal kinase inhibitor SP600125 is a ligand and antagonist of the aryl hydrocarbon receptor. Drug Metab Dispos 31,1279-1282.
14. Kanungo J, Potapova I, Malbon CC and Wang H (2000). MEKK4 mediates differentiation in response to retinoic acid via activation of c-Jun N-terminal kinase in rat embryonal carcinoma P19 cells. J Biol Chem 275,24032-24039.
15. Kuan CY, Yang DD, Samanta Roy DR, Davis RJ, Rakic P and Flavell RA (1999). The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development. Neuron 22,667-676.
16. Kwong WY, Wild AE, Roberts P, Willis AC and Fleming TP (2000). Maternal undernutrition during the preimplantation period of rat development causes blastocyst abnormalities and programming of postnatal hypertension. Development 127,4195-4202.
17. Kwong WY, Osmond C and Fleming TP (2004). Support for Barker hypothesis upheld in rat model of maternal undernutrition during the preimplantation period: Application of integrated 'random effects' statistical model. Reprod Biomed Online 8,574-576.
18. Lane M and Gardner DK (2005). Understanding cellular disruptions during early embryo development that perturb viability and fetal development. Reprod Fertil Dev 17,371-378.
19. Lee YN, Malbon CC and Wang HY (2004) G alpha 13 signals via p115RhoGEF cascades regulating JNK1 and primitive endoderm formation. J Biol Chem 279,54896-54904.
20. Leese HJ (2002) Quiet please, do not disturb: A hypothesis of embryo metabolism and viability. Bioessays 24,845-849.
21. Maekawa M, Yamamoto T, Tanoue T, Yuasa Y, Chisaka O and Nishida E (2005) Requirement of the MAP kinase signaling pathways for mouse preimplantation development. Development 132,1773-1783.
22. Mudgett JS, Ding J, Guh-Siesel L, Chartrain NA, Yang L, Gopal S and Shen MM (2000) Essential role for p38alpha mitogen-activated protein kinase in placental angiogenesis. Proc Natl Acad Sci USA 97,10454-10459.
23. Natale DR, Paliga AJ, Beier F, D'Souza SJ and Watson AJ (2004) p38 MAPK signaling during murine preimplantation development. Dev Biol 268,76-88.
24. Rappolee DA (2003) Signal transduction. In Krawetz S and Womble D (ed.), Introduction to Bioinformatics. A Theoretical and Practical Approach. Humana Press, Totowa, New Jersey, pp. 55-71.
25. Rassoulzadegan M, Rosen BS, Gillot I and Cuzin F (2000) Phagocytosis reveals a reversible differentiated state early in the development of the mouse embryo. Embo J 19,3295-3303.
26. Summers MC and Biggers JD (2003) Chemically defined media and the culture of mammalian preimplantation embryos: Historical perspective and current issues. Hum Reprod Update 9,557-582.
27. Thompson NA, Haefliger JA, Senn A, Tawadros T, Magara F, Ledermann B, Nicod P and Waeber G (2001) Islet-brain1/JNK-interacting protein-1 is required for early embryogenesis in mice. J Biol Chem 276,27745-27748.
28. Wang HY, Kanungo J and Malbon CC (2002) Expression of Galpha 13 (Q226L) induces P19 stem cells to primitive endoderm via MEKK1, 2, or 4. J Biol Chem 277,3530-3536.
29. Wang Y, Puscheck EE, Wygle DL, Lewis JJ, Trostinskaia AB, Wang F and Rappolee DA (2005) Increases in phosphorylation of SAPK/JNK and p38MAPK correlate negatively with mouse embryo development after culture in different media. Fertil Steril 83,1144-1154.
30. Whitten WK and Biggers JD (1968) Complete development in vitro of the preimplantation stages of the mouse in a simple chemically defined medium. J Reprod Fertil 17,399-401.
31. Xie Y, Wang F, Zhong W, Puscheck EE, Shen H and Rappolee DA (submitted for publication) Shear stress causes rapid lethality in preimplantation mouse embryos by induction of SAPK/JNK-mediated TUNEL/apoptosis that is delayed by the Zona pellucida. Development.
32. Xie Y, Wang T, Sun T, Wang Y, Wang F, Puscheck EE and Rappolee DA (2005a) Acquisition of essential somatic cell cycle regulatory protein expression and implied activity occurs at the second to third cell division in mouse preimplantation embryos. FEBS Lett 579(2),398-408.
33. Xie Y, Wang Y, Sun T, Wang F, Trostinskaia A, Puscheck EE and Rappolee DA (2005b) Six post-implantation lethal knockouts of genes for lipophilic MAPK pathway proteins are expressed in preimplantation mouse embryos and trophoblast stem cells. Mol Reprod Dev 71,1-11.
34. Xie Y, Wang F, Zhong W, Puscheck EE, Shen H and Rappolee DA (2006). Shear Stress Induces Preimplantation Embryo Death That is Delayed By the Zona Pellucida and Associated with Stress-Activated Protein Kinase-mediated Apoptosis. Biology of Reproduction In press.
35. Zhong W, Sun T, Wang Q, Wang Y, Xie Y, Johnson A, Leach R, Puscheck EE and Rappolee DA (2004) SAPK/JNK1, 2, but not SAPK/JNK3 mRNA transcripts, are expressed in early gestation human placenta and mouse eggs, preimplantation embryos, and trophoblast stem cells. Fertil Steril 82,1140-1148.
36. Zhong W, Wang Y, Lewis J, Xie Y and Rappolee DA (submitted for publication) Elevated SAPK/JNK1, 2 phospho mediates rapid stress-induced, dose-dependent apoptotic and mitogenic suppression and slower apoptotic and cell cycle arrest in placental cells and embryos. Dev Biol.