Expression of HIF-1α and iNOS in astrocytic gliomas: A clinicopathological study

In Vivo

Volumn 20, Issue 3, 2006, Pages 421-426

  Giannopoulou, E ^a   Ravazoula, P ^a   Kalofonos, H ^a   Makatsoris, T H ^a   Kardamakis, Dimitrios ^a  

^a UNIVERSITY OF PATRAS   (Greece)

Author keywords

Astrocytic gliomas; HIF 1 ; iNOS

Indexed keywords

FORMALDEHYDE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INDUCIBLE NITRIC OXIDE SYNTHASE; PARAFFIN; HIF1A PROTEIN, HUMAN; TUMOR MARKER;

ARTICLE; ASTROCYTE; CAPILLARY WALL; CELL NUCLEUS; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOPLASM; DISEASE SEVERITY; GLIOMA; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; OUTCOMES RESEARCH; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; SURVIVAL; ADULT; AGED; ASTROCYTOMA; BIOSYNTHESIS; COMPARATIVE STUDY; ENZYME INDUCTION; ENZYMOLOGY; FEMALE; GENE EXPRESSION REGULATION; GENETICS; MALE; METABOLISM; MIDDLE AGED; PATHOLOGY; RETROSPECTIVE STUDY;

ADULT; AGED; ASTROCYTOMA; ENZYME INDUCTION; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; NITRIC OXIDE SYNTHASE TYPE II; RETROSPECTIVE STUDIES; TUMOR MARKERS, BIOLOGICAL;

EID: 33646844227     PISSN: 0258851X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Holland E: Gliomagenesis: genetic alterations and mouse models. Nat Rev 2: 120-129, 2001.
2. Knisely JPS and Rockwell S: Importance of hypoxia in the biology and treatment of brain tumours. Neuroimag Clin N Am 12: 525-536, 2002.
3. Semenza GL: Signal transduction to hypoxia-inducible factor 1. Bioch Pharmacol 64: 993-998, 2002.
4. Hewitson KS and Schofield CJ: The HIF pathway as a therapeutic target. Drug Discov Today 15: 704-711, 2004.
5. Broholm H, Braendstrup O and Lauritzen M: Nitric oxide synthase expression of oligodendrogliomas. Clin Neuropathol 6: 233-238, 2001.
6. Sondergaard KL, Hilton DA, Penney M, Ollerenshaw M and Demaine AG: Expression of hypoxia-inducible factor 1α in tumours of patients with glioblastoma. Neuropathol Appl Neurobiol 28: 210-217, 2002.
7. Yoshida D, Kim K, Noha M and Teramoto A: Hypoxia inducible factor 1α regulates of platelet derived growth factor-B in human glioblastoma cells. J Neurooncol 30: 2005.
8. Brat DJ and Mapstone TB: Malignant glioma physiology: cellular response to hypoxia and its role in tumour progression. Ann Intern Med 138: 659-668, 2003.
9. Hanahan D and Folkman J: Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 86: 353-364, 1996.
10. Plate KH, Breier G, Weich HA and Risau W: Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo. Nature 359: 845-848, 1992.
11. Shweiki D, Itin A, Soffer D and Keshet E: Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiate angiogenesis. Nature 359: 843-845, 1992.
12. Yeo EJ, Chun YS and Park JW: New anticancer strategies targeting HIF-1. Biochem Pharmacol 68: 1061-1069, 2004.
13. Semenza GL: Targeting HIF-1 for cancer therapy. Nat Rev Cancer 3: 721-732, 2003.
14. Vordermark D and Brown JM: Evaluation of hypoxia-inducible factor-1α (HIF-1α) as an intrinsic marker of tumour hypoxia in U87 MG human glioblastoma: in vitro and xenograft studies. Int J Rad Oncol Biol Phys 56(4): 1184-1193, 2003.
15. Korkolopoulou P, Patsouris E, Konstantinidou AE, Pavlopoulos PM, Kavantzas N, Boviatsis E, Thymara I, Perdiki M, Thomas-Tsagli E, Angelidakis D, Rologis D and Sakkas D: Hypoxia-inducible factor 1α/ vascular endothelial growth factor axis in astrocytomas. Associations with microvessel morphometry, proliferation and prognosis. Neuropathol Appl Neurobiol 30: 267-278, 2004.
16. Park JW, Chun YS and Kim MS: Hypoxia-inducible factor 1-related diseases and prospective therapeutic tools. J Pharmacol Sci 94: 221-232, 2004.
17. Hofseth LJ, Perwez Hussain S, Wogan GN and Harris CC: Nitric oxide in cancer and chemoprevention. Free Rad Biol Med 34(8): 955-968, 2003.
18. Shinoda J and Whittle IR: Nitric oxide and glioma: a target for novel therapy. Br J Neurosurg 15(3): 213-220, 2001.
19. Bakshi A, Nag TC, Wadhwa S, Mahapatra AK and Sarkar C: The expression of nitric oxides synthases in human brain tumours and peritumoural areas. J Neurol Sci 155: 196-203, 1998.
20. Cobbs CS, Brenman JE, Aldape KD, Bredt DS and Israel MA: Expression of nitric oxide synthase in human central nervous system tumours. Cancer Res 55: 727-730, 1995.
21. Hara E, Takahashi K, Tominaga T, Kumabe T, Kayama T, Suzuki H, Fujita H, Yoshimoto T, Shirato K and Shibahara S: Expression of heme oxygenase and inducible nitric oxide synthase mRNA in human brain tumours. Biochem Biophys Res Commun 224: 153-158, 1996.
22. Ellie E, Loiseau H, Lafond F, Arsaut J and Demotes-Mainard J: Differential expression of inducible nitric oxide synthase mRNA in human brain tumours. Neuroreport 7: 294-296, 1995.
23. Kong L, Dunn GD, Keefer LK and Korthuis RJ: Nitric oxide reduces tumour cell adhesion to isolated rat post capillary venules. Clin Exp Metastasis 14: 335-343, 1996.
24. Dong Z, Staroselsky AH, Qi X, Xie K and Fidler IJ: Inverse correlation between expression of inducible nitric oxide synthase activity and production of metastasis in K-1735 murine melanoma cells. Cancer Res 54: 789-793, 1994.
25. Murata J, Ricciardi-Castagnoli P, Dessous L'Eglise Mange P, Martin F and Juillerat-Jeanneret L: Microglial cells induce cytotoxic effects toward colon carcinoma cells: measurement of tumour cytotoxicity with a gamma-glutamyl transpeptidase assay. Int J Cancer 70: 169-174, 1997.