Fully flexible docking models of the complex between α7 nicotinic receptor and a potent heptapeptide inhibitor of the β-amyloid peptide binding

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 13, 2006, Pages 3519-3523

  Espinoza Fonseca, L Michel ^a,b,c   Trujillo Ferrara, José G ^b,c  

^a UNIVERSITY OF MINNESOTA   (United States)

^b Sección de Estudios de Posgrado e Investigación de la Escuela Superior de Medicina del IPN   (Mexico)

^c INSTITUTO POLITÉCNICO NACIONAL   (Mexico)

Author keywords

7 Nicotinic acetylcholine receptor; Amyloid peptide; Alzheimer's disease; Docking; Drug design; Molecular dynamics simulations

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-40]; BUNGAROTOXIN RECEPTOR; CHOLINERGIC RECEPTOR; HEPTAPEPTIDE; PROTEIN INHIBITOR; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; BINDING SITE; BIOAVAILABILITY; HUMAN; MOLECULAR DYNAMICS; PROTEIN BINDING; PROTEIN STRUCTURE;

AMYLOID BETA-PROTEIN; BINDING SITES; HUMANS; LIGANDS; MODELS, MOLECULAR; OLIGOPEPTIDES; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, NICOTINIC; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33646842340     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.03.093     Document Type: Article

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