Base docking model of the homomeric α7 nicotinic receptor-β- amyloid1-42 complex

Biochemical and Biophysical Research Communications

Volumn 320, Issue 2, 2004, Pages 587-591

  Espinoza Fonseca, L Michel ^a  

^a Faculty of Natural Sciences   (Slovakia)

Author keywords

7 Nicotinic receptor amyloid1 42 complex; Amyloid1 42; Homomeric 7 nicotinic receptor; Protein protein docking simulations

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; NICOTINIC RECEPTOR; PEPTIDE; RECEPTOR PROTEIN;

ALZHEIMER DISEASE; ARTICLE; BASE PAIRING; COMPUTER PROGRAM; DYNAMICS; EXPERIMENT; HUMAN; METHODOLOGY; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; STRUCTURE ANALYSIS;

AMYLOID BETA-PROTEIN; HUMANS; MODELS, MOLECULAR; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PEPTIDE FRAGMENTS; PROTEIN CONFORMATION; RECEPTORS, NICOTINIC;

EID: 2942729673     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2004.05.207     Document Type: Article

References (26)

1. Selkoe D.J. The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease. Trends Cell. Biol. 8:1998;447-453
2. 1-42 binds to α7 nicotinic receptor with high affinity: implications for the Alzheimer's disease pathology. J. Biol. Chem. 275:2000;5626-5632
3. 1 - 42 binds selectively and with picomolar affinity to α7 nicotinic acetylcholine receptors J. Neurochem. 75:2000;1155-1161
4. Pettit D.L., Shao Z., Yakel J.L. β-Amyloid (1-42) peptide directly modulates nicotinic receptors in the rat hippocampal slice. J. Neurosci. 21:2001;RC120
5. Lui Q., Kawai H., Berg D.K. β-Amyloid peptide blocks the response of α7-containing nicotinic receptors on hippocampal neurons. Proc. Natl. Acad. Sci. USA. 98:2001;4734-4739
6. Tozaki H., Matsumoto A., Kanno T., Nagai K., Nagata T., Yamamoto S., Nishizaki T. The inhibitory and facilitatory actions of amyloid-β peptides on nicotinic ACh receptors and AMPA receptors. Biochem. Biophys. Res. Commun. 294:2002;42-45
7. Dineley K.T., Westerman M., Bui D., Bell K., Hsiao-Ashe K., Sweatt J.D. β-Amyloid activates the mitogen-activated protein kinase cascade via hippocampal α7 nicotinic acetylcholine receptors: in vitro and in vivo mechanisms related to Alzheimer's disease. J. Neurosci. 21:2001;4125-4133
8. Wang H.Y., Li W., Benedetti N.J., Lee D.H.S. α7 Nicotinic acetylcholine receptors mediate β-amyloid peptides-induced tau protein phosphorylation. J. Biol. Chem. 278:2003;31547-31553
9. Seguela P., Wadiche J., Dineley-Miller K., Dani J.A., Patrick J.W. Molecular cloning, functional properties, and distribution of rat brain alpha 7: a nicotinic cation channel highly permeable to calcium. J. Neurosci. 13:1993;496-604
10. Quik M., Philie J., Choremis J. Modulation of α7 nicotinic receptor-mediated calcium influx by nicotinic agonists. Mol. Pharmacol. 51:1997;499-506
11. McGehee D.S., Heath M.J.S., Gelber S., Devay P., Role L.W. Nicotine enhancement of fast excitatory synaptic transmission in CNS by presynaptic receptors. Science. 269:1995;1692-1696
12. Orr-Urtreger A., Goldner F.M., Saeki M., Lorenzo I., Goldberg L., De Biasi M., Dani J.A., Patrick J.W., Beaudet A.L. Mice deficient in the α7 neuronal nicotinic acetylcholine receptor lack α-bungarotoxin binding sites and hippocampal fast nicotinic currents. J. Neurosci. 17:1997;9165-9171
13. Broide R.S., Leslie F.M. The α7 nicotinic acetylcholine receptor in neuronal plasticity. Mol. Neurobiol. 20:1999;1-16
14. Brejc K., van Dijk W.K., Klaassen R.V., Shuurmans M., van der Oost J., Smith A.B., Sixma T.K. Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors. Nature. 411:2001;269-276
15. Ausiello G., Cesareni G., Helmer-Citterich M. ESCHER: a new docking procedure applied to the reconstruction of protein tertiary structure. Proteins. 28:1997;556-567
16. Henchman R.H., Wang H.L., Sine S.M., Taylor P., McCammon J.A. Asymmetric structural motions of the homomeric α7 nicotinic receptor ligand binding domain revealed by molecular dynamics simulation. Biophys. J. 85:2003;3007-3018
17. Schwede T., Kopp J., Guex N., Peitsch M.C. SWISS-MODEL: an automated protein homology-modeling server. Nucleic Acids Res. 31:2003;3381-3385
18. Guex N., Peitsch M.C. SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modelling. Electrophoresis. 18:1997;2714-2723
19. Peitsch M.C. Protein modeling by E-mail. BioTechnology. 13:1995;658-660
20. Vriend G. WHAT IF: a molecular modelling and drug design program. J. Mol. Graph. 8:1990;52-56
21. Hooft R.W.W., Vriend G., Sander C., Abola E.E. Errors in protein structures. Nature. 381:1996;272
22. Kale L., Skeel R., Bhandarkar M., Brunner R., Gursoy A., Krawetz N., Phillips J., Shinozaki A., Varadarajan K., Schulten K. NAMD2: greater scalability for parallel molecular dynamics. J. Comput. Phys. 151:1999;283
23. Sine S.M., Wang H.L., Bren N. Lysine scanning mutagenesis delineates structural model of the nicotinic receptor ligand binding domain. J. Biol. Chem. 277:2002;29210-29223
24. Fruchart-Gaillard C., Gilquin B., Antil-Delbeke S., Le Novère N., Tamiya T., Corringer P.J., Changeux J.P., Ménez A., Servent D. Experimentally based model of a complex between a snake toxin and the α7 nicotinic receptor. Proc. Natl. Acad. Sci. USA. 99:2002;3216-3221
25. Harel M., Kasher R., Nicolas A., Guss J.M., Balass M., Fridkin M., Smit A.B., Brejc K., Sixma T.K., Katchalski-Katzir E., Sussman J.L., Fuchs S. The binding site of acetylcholine receptor as visualized in the X-Ray structure of a complex between α-bungarotoxin and a mimotope peptide. Neuron. 32:2001;265-276
26. McDonald I.K., Thornton J.M. Satisfying hydrogen bonding potential in proteins. J. Mol. Biol. 238:1994;777-793