The existence of a second allosteric site on the M1 muscarinic acetylcholine receptor and its implications for drug design

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 5, 2006, Pages 1217-1220

  Espinoza Fonseca, L Michel ^a   Trujillo Ferrara, José G ^b  

^a UNIVERSITY OF MINNESOTA   (United States)

^b INSTITUTO POLITÉCNICO NACIONAL   (Mexico)

Author keywords

Alzheimer's disease; Blind docking; M1 muscarinic receptor; Molecular dynamics simulations; Multiple allosteric sites; Relax complex scheme; Staurosporine derivatives

Indexed keywords

DOCKING PROTEIN; KT 5720; MUSCARINIC M1 RECEPTOR; MUSCARINIC RECEPTOR;

ALGORITHM; ALLOSTERISM; ALZHEIMER DISEASE; ARTICLE; COMPUTER SIMULATION; DRUG DESIGN; DRUG STRUCTURE; EXTRACELLULAR SPACE; INTRACELLULAR SPACE; MOLECULAR DYNAMICS; MOLECULAR MODEL;

ALLOSTERIC SITE; CARBAZOLES; DRUG DESIGN; INDOLES; MODELS, MOLECULAR; PROTEIN STRUCTURE, TERTIARY; PYRROLES; RECEPTOR, MUSCARINIC M1;

EID: 31344434532     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.11.097     Document Type: Article

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