Reducing CDK4/6-p16INK4a interface: Computational alanine scanning of a peptide bound to CDK6 protein

Proteins: Structure, Function and Genetics

Volumn 63, Issue 4, 2006, Pages 797-810

  Villacañas, Óscar ^a   Rubio Martinez, Jaime ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

Author keywords

Binding free energy; CDK4 6; Cell cycle; Homology modeling; Molecular dynamics; Molecular modeling; p16INK4a; Solvation free energy

Indexed keywords

ALANINE; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; PEPTIDE; PROTEIN P16INK4A;

AMINO ACID SUBSTITUTION; ARTICLE; CELL CYCLE; CELL CYCLE G1 PHASE; CRYSTAL STRUCTURE; ENERGY; ENTHALPY; ENTROPY; MOLECULAR DYNAMICS; MOLECULAR MODEL; MUTAGENESIS; PEPTIDE ANALYSIS; PRIORITY JOURNAL; PROTEIN BINDING; STRUCTURE ANALYSIS; THERMODYNAMICS; TUMOR SUPPRESSOR GENE;

ALANINE; BINDING SITES; COMPUTER SIMULATION; CYCLIN-DEPENDENT KINASE 4; CYCLIN-DEPENDENT KINASE 6; CYCLIN-DEPENDENT KINASE INHIBITOR P16; ELECTROSTATICS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN STRUCTURE, QUATERNARY; STRUCTURAL HOMOLOGY, PROTEIN; THERMODYNAMICS; WATER;

EID: 33646800468     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.20943     Document Type: Article

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