Heme catalyzes tyrosine 385 nitration and inactivation of prostaglandin H2 synthase-1 by peroxynitrite

Journal of Lipid Research

Volumn 47, Issue 5, 2006, Pages 898-911

  Deeb, Ruba S ^a   Hao, Gang ^b   Gross, Steven S ^a,b   Lainé, Muriel ^a   Ju, Hua Qiu ^a   Resnick, Brad ^a   Barbar, Elisar J ^c   Hajjar, David P ^a   Upmacis, Rita K ^a  

^a Weill Cornell Medical College of Cornell University   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c OREGON STATE UNIVERSITY   (United States)

Author keywords

Cyclooxygenase; Eicosanoids; Heme reconstitution; Mass spectrometry; Peroxidase activity; Proteolysis

Indexed keywords

AMINO ACID SEQUENCE; ANIMALS; APOENZYMES; BINDING SITES; CATALYSIS; CHROMATOGRAPHY, ION EXCHANGE; CYCLOOXYGENASE 1; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FREE RADICAL SCAVENGERS; HEME; HEMIN; HOLOENZYMES; HYDROXYL RADICAL; MALE; MODELS, CHEMICAL; MOLECULAR SEQUENCE DATA; MOLSIDOMINE; PEROXYNITROUS ACID; SEMINAL VESICLES; SHEEP; TYROSINE;

EID: 33646800153     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M500384-JLR200     Document Type: Article

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