Peroxidase Self-inactivation in Prostaglandin H Synthase-1 Pretreated with Cyclooxygenase Inhibitors or Substituted with Mangano Protoporphyrin IX

Journal of Biological Chemistry

Volumn 276, Issue 23, 2001, Pages 19879-19888

  Wu, Gang ^a   Vuletich, Jennifer L ^b   Kulmacz, Richard J ^a   Osawa, Yoichi ^b   Tsai, Ah Lim ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; CHROMATOGRAPHIC ANALYSIS; ENZYME INHIBITION; MANGANESE; MASS SPECTROMETRY; PROTEINS; REACTION KINETICS; SPECTROSCOPIC ANALYSIS; SUBSTITUTION REACTIONS;

INACTIVATION RATES;

BIOCHEMISTRY;

FLURBIPROFEN; HEME; INDOMETACIN; IRON; MANGANESE; MANGANOPROTOPORPHYRIN IX; METALLOPORPHYRIN; PEROXIDASE; PEROXIDE; PROSTAGLANDIN H SYNTHASE 1; PROSTAGLANDIN SYNTHASE; PROSTAGLANDIN SYNTHASE INHIBITOR; PROTOPORPHYRIN; RADICAL; TYROSINE; UNCLASSIFIED DRUG; CYCLOOXYGENASE 1; ISOENZYME; MANGANESE PROTOPORPHYRIN;

ABSORPTION SPECTROSCOPY; ANALYTIC METHOD; ANIMAL TISSUE; ARTICLE; CATALYSIS; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME KINETICS; ENZYME MECHANISM; ENZYME MODIFICATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; PROTEIN DEGRADATION; PROTEIN STRUCTURE; SPECIES; STATISTICAL SIGNIFICANCE; STOPPED FLOW SPECTROSCOPY METHOD; STRUCTURE ANALYSIS; CHEMISTRY; DRUG ANTAGONISM; ELECTROSPRAY MASS SPECTROMETRY; KINETICS; METABOLISM; PROTEIN CONFORMATION;

ANIMALIA;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYCLOOXYGENASE 1; CYCLOOXYGENASE INHIBITORS; FLURBIPROFEN; HEME; INDOMETHACIN; ISOENZYMES; KINETICS; PEROXIDASES; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROTEIN CONFORMATION; PROTOPORPHYRINS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 0035827550     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M100628200     Document Type: Article

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