Leucine-rich repeat-containing G-protein-coupled receptor 8 in mature glomeruli of developing and adult rat kidney and inhibition by insulin-like peptide-3 of glomerular cell proliferation

Journal of Endocrinology

Volumn 189, Issue 2, 2006, Pages 397-408

  Fu, P ^a,b   Shen, P J ^a   Zhao, C X ^a   Scott, D J ^a   Samuel, C S ^a   Wade, J D ^a   Tregear, G W ^a   Bathgate, R A D ^a   Gundlach, A L ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b MONASH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 8; INSULIN LIKE PEPTIDE 3; IODINE 125; MESSENGER RNA; PEPTIDE HORMONE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING SITE; CELL CULTURE; CELL DENSITY; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; FEMALE; GESTATIONAL AGE; GLOMERULUS; HISTOCHEMISTRY; IN SITU HYBRIDIZATION; ISOTOPE LABELING; KIDNEY CELL; KIDNEY CORTEX; KIDNEY DEVELOPMENT; MALE; MESANGIUM CELL; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; QUANTITATIVE ANALYSIS; RAT; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

ANIMALS; BINDING SITES; CELL DIVISION; CELLS, CULTURED; CLONING, MOLECULAR; FEMALE; IN SITU HYBRIDIZATION; INSULIN; KIDNEY; KIDNEY GLOMERULUS; MALE; PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, G-PROTEIN-COUPLED; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEQUENCE ANALYSIS, DNA; SIGNAL TRANSDUCTION;

EID: 33646789465     PISSN: 00220795     EISSN: None     Source Type: Journal    
DOI: 10.1677/joe.1.06697     Document Type: Article

References (51)

1. Adham IM, Emmen JM & Engel W 2000 The role of the testicular factor INSL3 in establishing the gonadal position. Molecular and Cellular Endocrinology 160 11-16.
2. Adham IM, Steding G, Thamm T, Bullesbach EE, Schwabe C, Paprotta I & Engel W 2002 The overexpression of the Insl3 gene in female mice causes descent of the ovaries. Molecular Endocrinology 16 244-252.
3. Balvers M, Spiess AN, Domagalski R, Hunt N, Kilic E, Mukhopadhyay AK, Hanks E, Charlton HM & Ivell R 1998 Relaxin-like factor expression as a marker of differentiation in the mouse testis and ovary. Endocrinology 136 2960-2970.
4. Bathgate RAD, Samuel CS, Burazin TCD, Gundlach AL & Tregear GW 2003 Relaxin: new peptides, receptors and novel actions. Trends in Endocrinology and Metabolism 14 207-213.
5. Bathgate RAD, Ivell R, Sanborn BM, Sherwood OD & Summers RJ 2005 Receptors for relaxin family peptides. Annals of the New York Academy of Sciences 1041 61-76.
6. Blom IE, van Dijk AJ, Wieten L, Duran K, Ito Y, Kleij L, deNichilo M, Rabelink TJ, Weening JJ, Aten J et al. 2001 In vitro evidence for differential involvement of CTGF, TGFβ, and PDGF-BB in mesangial response to injury. Nephrology, Dialysis, Transplantation 16 1139-1148.
7. Bogatcheva NV & Agoulnik AI 2005 INSL3/LGR8 role in testicular descent and cryptorchidism. Reproductive Biomedicine Online 10 49-54.
8. Bogatcheva NV, Truong A, Feng S, Engel W, Adham IM & Agoulnik AI 2003 GREAT/LGR8 is the only receptor for insulin-like 3 peptide. Molecular Endocrinology 17 2639-2646.
9. Boockfor FR, Fullbright G, Bullesbach EE & Schwabe C 2001 Relaxin-like factor (RLF) serum concentrations and gubernaculum RLF receptor display in relation to pre- and neonatal development of rats. Reproduction 122 899-906.
10. Büllesbach EE & Schwabe C 2005 LGR8 signal activation by the relaxin-like factor. Journal of Biological Chemistry 280 14586-14590.
11. Büllesbach EE, Rhodes R, Rembiesa B & Schwabe C 1999 The relaxin-like factor is a hormone. Endocrine 10 167-169.
12. Burazin TCD, Bathgate RAD, Macris M, Layfield S, Gundlach AL & Tregear GW 2002 Restricted, but abundant, expression of the novel rat gene-3 (R3) relaxin in the dorsal tegmental region of brain. Journal of Neurochemistry 82 1553-1557.
13. Burazin TCD, Johnson KJ, Ma S, Bathgate RAD, Tregear GW & Gundlach AL 2005 Localization of LGR7 (relaxin receptor) mRNA and protein in rat forebrain: Correlation with relaxin binding site distribution. Annals of the New York Academy of Sciences 1041 205-210.
14. Danielson LA, Sherwood OD & Conrad KP 1999 Relaxin is a potent renal vasodilator in conscious rats. Journal of Clinical Investigation 103 525-533.
15. Feld SM, Hirschberg R, Artishevsky A, Nast C & Adler SG 1995 Insulin-like growth factor I induces mesangial proliferation and increases mRNA and secretion of collagen. Kidney International 48 45-51.
16. Ferlin A, Simonato M, Bartoloni L, Rizzo G, Bettella A, Dottorini T, Dallapiccola B & Foresta C 2003 The INSL3-LGR8/GREAT ligand-receptor pair in human cryptorchidism. Journal of Clinical Endocrinology and Metabolism 88 4273-4279.
17. Floege J, Eng E, Young BA, Alpers CE, Barrett TB, Bowen-Pope DF & Johnson RJ 1993 Infusion of platelet-derived growth factor or basic fibroblast growth factor induces selective glomerular mesangial cell proliferation and matrix accumulation in rats. Journal of Clinical Investigation 92 2952-2962.
18. Fu P, Layfield S, Ferraro T, Tomiyama H, Hutson J, Otvos LJ, Tregear GW, Bathgate RAD & Wade JD 2004 Synthesis, conformation, receptor binding and biological activities of monobiotinylated human insulin-like peptide 3. Journal of Peptide Research 63 91-98.
19. Fu P, Shen P-J, Zhao C-X, Scott DJ, Samuel CS, Wade JD, Tregear GW, Bathgate RAD & Gundlach AL 2005 Detection, localization and action of the INSL3 receptor - LGR8 - in rat kidney. Annals of the New York Academy of Sciences 1041 516-519.
20. Gruden G, Thomas S, Burt D, Lane S, Chusney G, Sacks S & Viberti G 1997 Mechanical stretch induces vascular permeability factor in human mesangial cells: mechanisms of signal transduction. PNAS 94 12112-12116.
21. Haas CS, Schocklmann HO, Lang S, Kralewski M & Sterzel RB 1999 Regulatory mechanism in glomerular mesangial cell proliferation. Journal of Nephrology 12 405-415.
22. Hansen MB, Nielsen SE & Berg K 1989 Re-examination and further development of a precise and rapid dye method for measuring cell growth/ cell kill. Journal of Immunological Methods 119 203-210.
23. Harrison-Bernard LM, Navar LG, Ho MM, Vinson GP & el-Dahr SS 1997 Immunohistochemical localization of ANG II AT1 receptor in adult rat kidney using a monoclonal antibody. American Journal of Physiology 273 F170-FI77.
24. Hoffmann S, Podlich D, Hahnel B, Kriz W & Gretz N 2004 Angiotensin II type 1 receptor overexpression in podocytes induces glomerulosclerosis in transgenic rats. Journal of the American Society of Nephrology 15 1475-1487.
25. Hsu SYT 2003 New insights into the evolution of the relaxin-LGR signaling system. Trends in Endocrinology and Metabolism 14 303-309.
26. Hsu SYT, Nakabayashi K, Nishi S, Kumagai J, Kudo M, Sherwood OD & Hsueh AJW 2002 Activation of orphan receptors by the hormone relaxin. Science 295 671-674.
27. Hutson JM, Hasthorpe S & Heyns CF 1997 Anatomical and functional aspects of testicular descent and cryptorchidism. Endocrine Reviews 18 259-280.
28. Ivell R 1997 Biology of the relaxin-like factor (RLF). Reviews of Reproduction 2 133-138.
29. Jaffer F, Saunders C, Shultz P, Throckmorton D, Weinshell E & Abboud HE 1989 Regulation of mesangial cell growth by polypeptide mitogens. Inhibitory role of transforming growth factor beta. American Journal of Pathology 135 261-269.
30. Kamat AA, Feng S, Bogatcheva NV, Truong A, Bishop CE & Agoulnik AI 2004 Genetic targeting of relaxin and insulin-like factor 3 receptors in mice. Endocrinology 145 4712-4720.
31. Kawamura K, Kumagai J, Sudo S, Chun S-Y, Pisarska M, Morita H, Toppari J, Fu P, Wade JD, Bathgate RAD et al. 2004 Paracrine regulation of oocyte maturation and male germ cell survival. PNAS 101 7323-7328.
32. Kubota Y, Temelcos C, Bathgate RAD, Smith KJ, Scott DJ, Zhao C & Hutson JM 2002 The role of insulin 3, testosterone, Mullerian inhibiting substance and relaxin in rat gubernacular growth. Molecular Human Reproduction 8 900-905.
33. Kumagai J, Hsu SY, Matsumi H, Roh JS, Fu P, Wade JD, Bathgate RAD & Hsueh AJW 2002 INSL3/Leydig insulin-like peptide activates the LGR8 receptor important in testis descent. Journal of Biological Chemistry 277 31283-31286.
34. Loveland BE, Johns TG, Mackay IR, Vaillant F, Wang ZX & Hertzog PJ 1992 Validation of the MTT dye assay for enumeration of cells in proliferative and antiproliferative assays. Biochemistry International 27 501-510.
35. Ma J, Matsusaka T, Yang H, Kawachi H, Shimizu F, Isaka Y, Imai E, Kon V & Ichikawa I 2004 Local actions of endogenous angiotensin II in injured glomeruli. Journal of the American Society of Nephrology 15 1268-1276.
36. Nef S & Parada LF 1999 Cryptorchidism in mice mutant for Insl3. Nature Genetics 22 295-299.
37. Norwood VF, Craig MR, Harris JM & Gomez RA 1997 Differential expression of angiotensin II receptors during early renal morphogenesis. American Journal of Physiology 272 R662-R668.
38. Overbeek PA, Gorlov IP, Sutherland RW, Houston JB, Harrison WR, Boettger-Tong HL, Bishop CE & Agoulnik A 2001 A transgenic insertion causing cryptorchidism in mice. Genesis 30 26-35.
39. Pabst R & Sterzel RB 1983 Cell renewal of glomerular cell types in normal rats. An autoradiographic analysis. Kidney International 24 626-631.
40. Saile B, DiRocco P, Dudas J, El-Armouche H, Sebb H, Eisenbach C, Neubauer K & Ramadori G 2004 IGF-I induces DNA synthesis and apoptosis in rat liver hepatic stellate cells (HSC) but DNA synthesis and proliferation in rat liver myofibroblasts (rMF). Laboratory Investigation 84 1037-1049.
41. Schoecklmann HO, Rupprecht HD, Zauner I & Sterzel RB 1997 TGF-beta1-induced cell cycle arrest in renal mesangial cells involves inhibition of cyclin E-cdk 2 activation and retinoblastoma protein phosphorylation. Kidney International 51 1228-1236.
42. Schoecklmann HO, Lang S & Sterzel RB 1999 Regulation of mesangial cell proliferation. Kidney International 56 1199-1207.
43. Scott DJ, Layfield S, Riesewijk A, Morita H, Tregear GW & Bathgate RAD 2004 Identification and characterization of the mouse and rat relaxin receptors as the novel orthologs of human LGR7. Clinical and Experimental Pharmacology and Physiology 31 828-832.
44. Scott DJ, Fu P, Shen P-J, Gundlach AL, Layfield S, Riesewijk A, Tomiyama H, Hutson JM, Tregear GW & Bathgate RAD 2005 Characterization of the rat INSL3 receptor. Annals of the New York Academy of Sciences 1041 13-16.
45. Shankland SJ & Johnson RJ 1998 TGF-β in glomerular disease. Mineral and Electrolyte Metabolism 24 168-173.
46. Shen P-J & Gundlach AL 1996 Chromogranin mRNA levels in the brain as a market for acute and chronic changes in neuronal activity: Effect of treatments including seizures, osmotic stimulation and axotomy in the rat. European Journal of Neuroscience 8 988-1000.
47. Shen P-J, Fu P, Phelan KD, Scott DJ, Layfield S, Tregear GW, Bathgate RAD & Gundlach AL 2005 Restricted expression of LGR8 in intralaminar thalamic nuclei of rat brain suggests a role in sensorimotor systems. Annals of the New York Academy of Sciences 1041 510-515.
48. Siebel AL, Gehring HM, Nave CD, Bathgate RAD, Borchers CE & Parry LJ 2002 The upregulation of mesotocin receptors in the tammar wallaby myometrium is pregnancy-specific and independent of estrogen. Biology of Reproduction 66 1237-1243.
49. Spiess AN, Balvers M, Tena-Sempere M, Huhtaniemi I, Parry L & Ivell R 1999 Structure and expression of the rat relaxin-like factor (RLF) gene. Molecular Reproduction and Development 54 319-325.
50. Wisden W & Morris BJ 2002 In situ hybridization with oligonucleotide probes. International Review of Neurobiology 47 3-59.
51. Zimmermann S, Steding G, Emmen JM, Brinkmann AO, Nayernia K, Holstein AF, Engel W & Adham IM 1999 Targeted disruption of the Insl3 gene causes bilateral cryptorchidism. Molecular Endocrinology 13 681-691.