Restricted expression of LGR8 in intralaminar thalamic nuclei of rat brain suggests a role in sensorimotor systems

Annals of the New York Academy of Sciences

Volumn 1041, Issue , 2005, Pages 510-515

  Shen, Pei Juan ^a   Fu, Ping ^a   Phelan, Kevin D ^b   Scott, Daniel J ^a   Layfield, Sharon ^a   Tregear, Geoffrey W ^a   Bathgate, Ross A D ^a   Gundlach, Andrew L ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

Basal ganglia; LGR8; Locomotor control; Medial habenula; Parafascicular nucleus; Parkinson's disease

Indexed keywords

G PROTEIN COUPLED RECEPTOR; LEUCINE RICH REPEAT CONTAINING G PROTEIN COUPLED RECEPTOR 8; MESSENGER RNA; UNCLASSIFIED DRUG;

ANIMAL TISSUE; BASAL GANGLION; BRAIN REGION; BRAIN TISSUE; CELLULAR DISTRIBUTION; CONFERENCE PAPER; CONTROLLED STUDY; ELECTROPHYSIOLOGY; FOREBRAIN; GENE EXPRESSION; GENE FUNCTION; GENE IDENTIFICATION; IN SITU HYBRIDIZATION; NONHUMAN; PARKINSON DISEASE; PROTEIN LOCALIZATION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENSORIMOTOR FUNCTION; SIGNAL TRANSDUCTION; TESTIS DESCENT; THALAMUS; THALAMUS NUCLEUS; THALAMUS PARAFASCICULAR NUCLEUS; TISSUE DISTRIBUTION;

MAMMALIA;

EID: 23644455144     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1282.076     Document Type: Conference Paper

References (20)

1. HSU, S.Y., K. NAKABAYASHI, S. NISHI, et al. 2002. Activation of orphan receptors by the hormone relaxin. Science 295: 671-674.
2. HSU, S.Y.T., K. NAKABAYASHI, S. NISHI, et al. 2003. Relaxin signaling in reproductive tissues. Mol. Cell. Endocrinol. 202: 165-170.
3. HSU, S.Y.T. 2003. New insights into the evolution of the relaxin-LGR signaling system. Trends Endocrinol. Metab. 14: 303-309.
4. IVELL, R. 1997. Biology of the relaxin-like factor (RLF). Rev. Reprod. 2: 133-138.
5. OVERBEEK, P.A., I.P. GORLOV, R.W. SUTHERLAND, et al. 2001. A transgenic insertion causing cryptorchidism in mice. Genesis 30: 26-35.
6. NEF, S. & L.F. PARADA. 1999. Cryptorchidism in mice mutant for Insl3. Nat. Genet. 22: 295-299.
7. ZIMMERMANN, S., G. STEDING, J.M. EMMEN, et al. 1999. Targeted disruption of the Insl3 gene causes bilateral cryptorchidism. Mol. Endocrinol. 13: 681-691.
8. ADHAM, I.M., G. STEDING, T. THAMM, et al. 2002. The overexpression of the Insl3 gene in female mice causes descent of the ovaries. Mol. Endocrinol. 16: 244-252.
9. FERLIN, A., M. SIMONATO, L. BARTOLONI, et al. 2003. The INSL3-LGR8/GREAT ligand-receptor pair in human cryptorchidism. J. Clin. Endocrinol. Metab. 88: 4273-4279.
10. KUMAGAI, J., S.Y. HSU, H. MATSUMI, et al. 2002. INSL3/Leydig insulin-like peptide activates the LGR8 receptor important in testis descent. J. Biol. Chem. 277: 31283-31286.
11. BURAZIN, T.C.D., R.A.D. BATHGATE, M. MAORIS, et al. 2002. Restricted, but abundant, expression of the novel rat gene-3 (R3) relaxin in the dorsal tegmental region of brain. J. Neurochem. 82: 1553-1557.
12. LIN, L.-F.H., D.H. DOHERTY, J.D. LILE, et al. 1993. GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons. Science 260: 1130-1132.
13. WINKLER, C., H. SAUER, C.S. LEE & A. BJÖRKLUND. 1996. Short-term GDNF treatment provides long-term rescue of lesioned nigral dopaminergic neurons in a rat model of Parkinson's disease. J. Neurosci. 16: 7206-7215.
14. CONSOLO, S., P. BARONIO, G. GUIDI & G. DI CHIARA. 1996. Role of parafascicular thalamic nucleus and W-methyl-D-aspartate transmission in the D1-control of acetylcholine release in rat striatum. Neuroscience 71: 157-165.
15. VERCELLI, A., G. MARINI & G. TREDICI. 2003. Anatomical organization of the telencephalic connections of the parafascicular nucleus in adult and developing rats. Eur. J. Neurosci. 18: 275-289.
16. VAN DER WERF, Y.D., M.P. WITTER & H.J. GROENEWEGEN. 2002. The intralaminar and midline nuclei of the thalamus. Anatomical and functional evidence for participation in processes of arousal and awareness. Brain Res. Rev. 39: 107-140.
17. MAIR, R.G., J.A. BURK & M.C. PORTER. 1998. Lesions of the frontal cortex, hippocampus and intralaminar thalamic nuclei have distinct effects on remembering in rats. Behav. Neurosci. 112: 772-792.
18. HENDERSON, J.M., K. CARPENTER, H. CARTWRIGHT & G.M. HALLIDAY. 2000. Degeneration of the centré median-parafascicular complex in Parkinson's disease. Ann. Neurol. 47: 345-352.
19. HENDERSON, J.M., K. CARPENTER, H. CARTWRIGHT & G.M. HALLIDAY. 2000. Loss of thalamic intralaminar thalamus in progressive supranuclear palsy and Parkinson's disease: clinical and therapeutic implications. Brain 123: 1410-1421.
20. MENNEMEIER, M., E. FENNELL, E. VALENSTEIN & K.M. HEILMAN. 1992. Contributions of the left intralaminar and medial thalamic nuclei to memory. Comparisons and report of a case. Arch. Neurol. 149: 1050-1058.