Detection, localization, and action of the INSL3 receptor, LGR8, in rat kidney

Annals of the New York Academy of Sciences

Volumn 1041, Issue , 2005, Pages 516-519

  Fu, Ping ^a   Shen, Pei Juan ^a   Zhao, Chong Xin ^a   Scott, Daniel J ^a   Samuel, Chrishan S ^a   Wade, John D ^a   Tregear, Geoffrey W ^a   Bathgate, Ross A D ^a   Gundlach, Andrew L ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Development; in situ hybridization; Insulin like peptide 3 (INSL3) and relaxin; LGR7 and LGR8; Mesangial cell proliferation; Rat kidney; Real time PCR; Renal glomeruli

Indexed keywords

G PROTEIN COUPLED RECEPTOR; INSULIN LIKE PEPTIDE 3; LEUCINE RICH REPEAT CONTAINING G PROTEIN COUPLED RECEPTOR 8; MESSENGER RNA; RELAXIN LIKE FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; CELL CULTURE; CELL DENSITY; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CONFERENCE PAPER; CONTROLLED STUDY; EMBRYO; EMBRYONAL TISSUE; GENE FUNCTION; GENE IDENTIFICATION; GLOMERULUS; HORMONE ACTION; IN SITU HYBRIDIZATION; KIDNEY CORTEX; KIDNEY DEVELOPMENT; KIDNEY PARENCHYMA; MESANGIUM CELL; NONHUMAN; POLYMERASE CHAIN REACTION; PROTEIN LOCALIZATION; RAT;

EID: 23644434439     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1282.077     Document Type: Conference Paper

References (12)

1. IVELL, R. 1997. Biology of the relaxin-like factor (RLF). Rev. Reprod. 2: 133-138.
2. BATHGATE, R.A., C.S. SAMUEL, T.C. BURAZIN, et al. 2003. Relaxin: new peptides, receptors and novel actions. Trends Endocrinol. Metab. 14: 207-213.
3. NEF, S. & L.F. PARADA. 1999. Cryptorchidism in mice mutant for Insl3. Nat. Genet. 22: 295-299.
4. ZIMMERMANN, S., G. STEDING, J. M. EMMEN, et al. 1999. Targeted disruption of the Insl3 gene causes bilateral cryptorchidism. Mol. Endocrinol. 13: 681-691.
5. ADHAM, I.M., G. STEDING, T. THAMM, et al. 2002. The overexpression of the Insl3 in female mice causes descent of the ovaries. Mol. Endocrinol. 16: 244-252.
6. OVERBEEK, P.A., I.P. GORLOV, R.W. SUTHERLAND, et al. 2001. A transgenic insertion causing cryptorchidism in mice. Genesis 30: 26-35.
7. KUMAGAI, J., S.Y. HSU, H. MATSUMI, et al. 2002. INSL3/Leydig insulin-like peptide activates the LGR8 receptor important in testis descent. J. Biol. Chem. 277: 31283-31286.
8. FERLIN, A., M. SIMONATO, L. BARTOLONI, et al. 2003. The INSL3-LGR8/GREAT ligand-receptor pair in human cryptorchidism. J. Clin. Endocrinol. Metab. 88: 4273-4279.
9. HSU, S.Y., K. NAKABAYASHI, S. NISHI, et al. 2002. Activation of orphan receptors by the hormone relaxin. Science 295: 671-674.
10. GRUDEN, G., S. THOMAS, D. BURT, et al. 1997. Mechanical stretch induces vascular permeability factor in human mesangial cells: mechanisms of signal transduction. Proc. Natl. Acad. Sci. USA 94: 12112-12116.
11. HSU, S.Y. 2003. New insights into the evolution of the relaxin-LGR signaling system. Trends Endocrinol. Metab. 14: 303-309.
12. SCHOCKLMANN, H.O., S. LANG & R.B. STERZEL. 1999. Regulation of mesangial cell proliferation. Kidney Int. 56: 1199-1207.