Early bacterial colonisation of the intestine: Why it matters

Italian Journal of Pediatrics

Volumn 31, Issue 6, 2005, Pages 360-369

  Langhendries, J P ^a  

^a NICU ^*  (Belgium)

Author keywords

Bacteria; Immune induction; Intestinal colonisation; Neonate

Indexed keywords

FOOD ANTIGEN;

BACTERIAL COLONIZATION; BACTERIUM; CHILD CARE; ENTEROPATHY; HUMAN; IMMUNE SYSTEM; MAJOR HISTOCOMPATIBILITY COMPLEX; MICROFLORA; NEWBORN CARE; PERINATAL CARE; REVIEW; SYMBIOSIS;

EID: 33646766422     PISSN: 17208424     EISSN: 18247288     Source Type: Journal    
DOI: None     Document Type: Review

References (110)

1. Brabäck L, Hedberg A. Perinatal risk factors for atopic disease in conscripts. Clin Exp Allergy 1998;28:936-42.
2. Cummings JH, Antoine JM, Azpiroz F, Bourdet-Sicard R, Brandtzaeg P, Calder PC, et al. Gut health and immunity. Eur J Nutr 2004;43(Suppl 2):II118-73.
3. Rautava S, Russkanen O, Ouwehand A, Salminen S, Isolauri E. The hygiene hypothesis of atopic disease - an extended version. J Pediatr Gastroenterol Nutr 2004;38:378-88.
4. Mandar R, Mikelsaar M. Transmission of mother's microflora to the newborn at birth. Biol Neonate 1996;69:30-5.
5. Orrhage K, Nord CE. Factors controlling the bacterial colonization of the intestine in breast-fed infants. Acta Paediatr 1999;430(Suppl):47-57.
6. Mackie RI, Sghir A, Gaskins HR. Developmental microbial ecology of the neonatal gastrointestinal tract. Am J Clin Nutr 1999;69(Suppl):1035S-1045S.
7. Bäckhed F, Ley RE, Sonnenburg JL, Peterson DA, Gordon GI. Host-bacterial mutualism in the human intestine. Science 2005;307:1915-20.
8. Hooper LV, Wong MH, Thelin A, Hansson L, Falk PG, Gordon JI. Molecular analysis of commensal host-microbial relationships in the intestine. Science 2001;291:881-4.
9. Holt PG. Environmental factors and primary T-cell sensitisation to inhalant allergens in infancy: reappraisal of the role of infections and air pollution. Pediatr Allergy Immunol 1995;6:1-10.
10. Langhendries JP. Colonisation bactérienne de l'intestin dans le jeune âge et modulation du système immunitaire. Arch Pédiatr 2004;11:542-4.
11. Kalliomaki M, Salminen S, Arvilommi H, Kero P, Koskinen P, Isolauri E. Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial. Lancet 2001;357:1076-9.
12. Murch SH. Toll of allergy reduced by probiotics. Lancet 2001;357:1057-9.
13. Strannegard O, Strannegard I-L. The causes of the increasing prevalence of allergy: is atopy a microbial deprivation disorder? Allergy 2001;56:91-102.
14. Erb KJ. Atopic disorders: a default pathway in the absence of infection? Immunol Today 1999;20:317-22.
15. Matricardi PM, Rosmini F, Ferrigno L, Nisini R, Rapicetta M, Chionne P, et al. Cross sectional study of prevalence of atopy among Italian military students with antibodies against hepatitis A virus. BMJ 1997;314:999-1003.
16. Shaheen SO, Aaby P, Hall PJ, Barker DJP, Heyes CB, Shiell AW, et al. Measles and atopy in Guinea-Bissau. Lancet 1996;47:1792-6.
17. Ball TM, Castro-Rodriguez JA, Griffith KA, Holberg CJ, Martinez FD, et al. Siblings, day-care attendance, and the risk of asthma and wheezing during childhood. N Engl J Med 2000;343:538-43.
18. Alm JS, Swartz J, Lilja G, Scheynius A, Pershagen G. Atopy in children of families with anthroposophic lifestyle. Lancet 1999;353:1485-8.
19. Bach JF. The effect of infections on susceptibility to autoimmune and allergic diseases. N Engl J Med 2002;347:911-20.
20. Warner JO. The early life origins of asthma and related allergic disorders. Arch Dis Child 2004;89:97-102.
21. Guérin-Danan C, Andrieux C, Popot F, Charpilienne A, Vaissade P, Gaudichon C, et al. Pattern of metabolism and composition of the fecal microflora in infants 10 to 18 months old from day care centers. J Pediatr Gastroenterol Nutr 1997;25:281-9.
22. Björkstén B, Naaber P, Sepp E, Mikelsaar M. The intestinal microflora in allergic Estonian and Swedish 2-year-old children. Clin Exp Allergy 1999;29:32-346.
23. Ferguson A. Immunological functions of the gut in relation to nutritional state and mode of delivery of nutrients. Gut 1994;(Suppl 1):S10-S12.
24. Brandtzaeg P. Development of the mucosal immune system in humans. In: Bindels JG, Goedhart AC, Visser HKA, eds. Recent developments in Infant Nutrition. Dordrecht, the Netherlands: Kluwer Acad Pub 1996, pp. 349-376.
25. Kelsall B, Strober W. Gut-associated Lymphoid Tissue: Antigen Handling and T-Lymphocyte Responses. In: Ogra PL, Mestecky J, Lamm ME, Strober W, Bienenstock J, McGhee JR, eds. Mucosal Immunology. 2nd Ed. New-York: Academic press 1999.
26. Forchielli ML, Walker WA. The role of gut-associated lymphoid tissues and mucosal defence. Br J Nutr 2005;93:S41-8.
27. Pickard KM, Bremmer AR, Gordon JN, McDonald TT. Immune responses. Best Pract Res Clin Gastroenterol 2004;18:271-85.
28. Sudo N, Sawamura S, Tanaka K, Aiba Y, Kubo C, Koga Y. The requirement of intestinal bacterial flora for the development of an IgE production system fully susceptible to oral tolerance induction. J Immunol 1997;159:1739-45.
29. Strobel S. Neonatal oral tolerance. Ann N Y Acad Sci 1996;778:88-102.
30. Strobel S, Mowat A. Immune responses to dietary antigens: oral tolerance. Immunol Today 1998;19:173-81.
31. Brandtzaeg P. History of oral tolerance and mucosal immunity. Ann NY Acad Sc 1996;778:1-27.
32. Rakoff-Nahoum S, Paglino J, Eslami-Varzaneh F, Edberg S, Medzhitov R. Recognition of commensal microflora by Toll-like receptors is required for intestinal homeostasis. Cell 2004;118:229-41.
33. Aderem A, Ulevitch RJ. Toll-like receptors in the induction of the innate immune response. Nature 2000;406:782-7.
34. Hemmi H, Takeuchi O, Kawai T, Kaisho T, Sato S, Sanjo H, et al. A Toll-like receptot recognizes bacterial DNA. Nature 2000;408:740-5.
35. Stagg AJ, Hart AL, Knight SC, Kamm MA. Interactions between dendritic cells and bacteria in the regulation of intestinal immunity. Best Pract Res Clin Gastroenterol 2004;18:255-70.
36. Dabbagh K, Lewis DB. Toll-like receptors and T-helper-1/Thelper-2 responses. Curr Opin Infect Dis 2003;16:199-204.
37. Iwasaki A, Kelsall BL. Localization of distinct Peyer' patch dendritic cell subsets and their recruitment by chemokines macrophages inflammatory protein (MIP)-3alpha, MIP-3beta and secondary lymphoid organ chemokine. J Exp Med 2000;11:1381-94.
38. Iwasaki A, Kelsall L. Unique functions of CD11b+, CD8alpha, and double-negative Peyer's patch dendritic cells. J Immunol 2000;166:4884-90.
39. Murch SH. The immunologic basis for intestinal food allergy. Curr Opin Gastroenterol 2000;16:552-7.
40. Caramalho I, Lopez-Carvalho T, Ostler D, Zelenay S, Haury M, Demengeot J. Regulatory T Cells selectively express Toll-like receptors and are activated by lipopolysaccharide. J Exp Med 2003;197:403-11.
41. Singh B, Read S, Asseman C, Malmstrom M, Mottet C, Stephens LA, et al. Control of intestinal inflammation by regulatory T cells. Immunol Rev 2001;182:190-200.
42. Macfarlane GT, Gibson GR. Metabolic activities of the normal colonic flora. In: Gibson SAW, ed. Human health: the contributions of the microorganisms. London: Springer Verlag 1994, pp. 17-52.
43. Wolin MJ, Miller TL. Carbohydrates fermentation. In: Hentges DA, ed. Human intestinal flora and disease. New York: Academic Press 1983, pp. 147-165.
44. Gorbach SL. Function of the normal human microflora. Scand J Infect Dis 1986;49(Supp):17-30.
45. McGarr SE, Ridlon JM, Hylemon PB. Diet, anaerobic bacterial metabolism, and colon cancer: a review of the literature. J Clin Gastroenterol 2005;39:98-109.
46. Heavey PM, Rowland IR. Microbial-gut interactions in health and disease. Gastrointestinal cancer. Best Pract Res Clin Gastroenterol 2004;18:323-36.
47. Midtvedt AC, Carlstedt-Duke B, Norin KE, Saxerholt H, Midtvedt T. Development of five metabolic activities associated with the intestinal microflora of healthy infants. Pediatr Gastroenterol Nutr 1988;7:559-67.
48. Midtvedt AC, Midtvedt T. Production of short chain fatty acids by the intestinal microflora during the first 2 years of human life. J Pediatr Gastroenterol Nutr 1992;15:395-403.
49. Long SS, Swenson RM. Development of anaerobic fecal flora in healthy newborn infants. J Pediatr 1977;91:298-301.
50. Simhon A, Douglas JR, Drasar BS, Soothill J. Effect of feeding on infant's faecal flora. Arch Dis Child 1982;57:54-8.
51. Lundequist B, Nord CE, Winberg J. The composition of the faecal microflora in breast-fed and bottle-fed infants from birth to eight weeks. Acta Paediatr Scand 1985;74:45-51.
52. Borderon JC, Bernard JC, Vergnaud R, Gold F, Soutoul JH, Laugier J. Effet de l'antibiothérapie de la mère sur la colonisation du nouveau-né par entérobactéries. Arch Fr Pediatr 1980;37:371-6.
53. Bennet R, Nord CE. Development of the faecal anaerobic microflora after caesarean section and treatment with antibiotics in newborn infants. Infection 1987;15:332-6.
54. Neut C, Bezirtzoglou E, Romond C, Beerens H, Delcroix M, Noel AM. Bacterial colonization of the large intestin in newborns delivered by caesarean section. Zentralbl Bakteriol Mikrobiol 1987;266:330-7.
55. Udall JN Jr, Suskind RM. Cow's milk versus formula in older infants: consequences for human nutrition. Acta Paediatr 1999;430(Suppl):61-7.
56. Greco L, Aurichio S, Mayer M, Grimaldi M. Case control study on nutritional risk factors in caeliac disease. J Pediatr Gastroenterol Nutr 1988;7:395-9.
57. Bernt KM, Walker WA. Human milk as carrier of biochemical messages. Acta Paediatr 1999;430(Suppl):27-41.
58. Balmer SE, Wharton BA. Diet and fecal flora of newborn: breast milk and infant formula. Arch Dis Child 1989;64:1672-7.
59. Delneste Y, Donnet-Hughes A, Schiffrin EJ. Functional foods: mechanisms of action on immunocompetent cells. Nutrition Rev 1998;56:S93-8.
60. Van Odijk J, Kull I, Borres MP, Brandtzaeg P, Edberg U, Hanson LA, et al. Breastfeeding and allergic disease: a multidisciplinary review of the literature (1966-2001) on the mode of early feeding in infancy and its impact on later atopic manifestations. Allergy 2003;58:833-43.
61. Spiekermann GM, Walker WA. Oral tolerance and its role in clinical disease. J Pediatr Gastroenterol Nutr 2001;32:237-55.
62. Mayer L. Mucosal immunity. Pediatrics 2003;111:1595-600.
63. Grönlund MM, Arvilommi H, Kero P, Lehtonen OP, Isolauri E. Importance of intestinal colonisation in the maturation of humoral immunity in early infancy: a prospective follow-up study of healthy infants aged 0-6 months. Arch Dis Child Fetal Neonatal Ed 2000;83:F186-92.
64. Fusunyan RD, Nanthakumar NN, Baldeon ME, Walker WA. Evidence for an innate immune response in the immature human intestine: Toll-like receptors on fetal enterocytes. Pediatr Res 2001;49:589-93.
65. Filipp D, Alizadeh-Khiavi K, Richardson C, Palma A, Paredes N, Takeuchi O, et al. Soluble CD14 enriched in colostrum and milk induces B cell growth and differentiation. Proc Natl Acad Sci USA 2001;98:603-8.
66. Jones CA, Holloway JA, Popplewell EJ, Diaper ND, Holloway JW, Vance GHS, et al. Reduced soluble CD14 levels in amniotic fluid and breast milk are associated with the subsequent development of atopy, eczema, or both. J Allergy Clin Immunol 2002;109:858-66.
67. Hooper LV, Midvedt T Gordon JI. How host-microbial interactions shape the nutrient environment of the mammalian intestine. Annu Rev Nutr 2002;22:283-307.
68. Neish AS. The gut microflora and intestinal epithelial cells: a continuing dialogues. Microbes Infect 2002;4:309-17.
69. Nanthakumar NN, Fusunyan RD, Sanderson I, Walker WA. Inflammation in the developing human intestine: a possible pathophysiologic contribution to necrotizing enterocolitis. Proc Natl Acad Sci USA 2000;97:6043-8.
70. Mata LJ, Urrutia JJ. Intestinal colonization of breast-fed children in a rural area of low socioeconomic level. Am NY Acad Sci 1971;176:93-108.
71. Hall MA, Cole CB, Smith SL Fuller R, Rolles CJ. Factors influencing the presence of faecal Lactobacilli in early infancy. Arch Dis Child 1990;65:185-8.
72. Bennet R, Eriksson M, Nord CE, Zetterstrom R. Fecal bacterial microflora of newborn infants during intensive care management and treatment with five antibiotic regimens. Pediatr Infect Dis J 1986;5:533-9.
73. Grönlund MM, Lethonen OP, Eerola E, Kero P. Fecal microflora in healthy infants born by different methods of delivery: permanent changes in intestinal flora after caesarean delivery. J Pediatr Gastroenterol Nutr 1999;28:19-25.
74. Kero J, Gissler M, Grönlund MM, Kero P, Koskinen P, Hemminki E, et al. Mode of delivery and asthma - Is there a connection? Pediatr Res 2002;52:6-11.
75. Grönlund MM, Nuutila J, Pelto L, Lilius EM, Isolauri E, Salminen S, et al. Mode of delivery directs the phagocyte functions of infants for the first 6 months of life. Clin Exp Immunol 1999;116:521-6.
76. Gewolb IH, Schwalbe RS, Taciak VL, Harrisson TS, Panigrahi P. Stool microflora in extremely low birthweight infants. Arch Dis Child Fetal Neonatal 1999;80:F167-73.
77. Barrett JF, Jarvis GJ, McDonald HN, Buchan PC, Tyrrell SN, Lilford RJ. Inconsistencies in clinical decisions in obsterics. Lancet 1990;336:549-51.
78. Joffe M, Chapple J, Paterson C, Beard RW. What is the optimal caesarean section rate? An outcome based study of existing variation. J Epidemiol Community Health 1994;48:406-11.
79. Wilkinson C, McIlwaine G, Boulton-Jones C, Cole S. Is a rising caesarean section rate inevitable? Br J Obstet Gynaecol 1998;105:45-52.
80. Tannock GW, Fuller R, Smith SL, Hall MA. Plasmid profiling of members of the family Enterobacteriacae, Lactobacilli, and Bifidobacteria to study the transmission of bacteria from mother to infant. J Clin Microbiol 1990;28:1225-8.
81. de Marneffe C. Etude de la flore vaginale de la mère hospitalisée dans un service de grossesses à haut risque. Mémoire de Licence en Sciences de la Santé publique, Université de Liège, Presse universitaire, Liège 2005.
82. Mercer BM, Carr TL, Beazley DD, Crouse DT, Sibai BM. Antibiotics use in pregnancy and drug-resistant infant sepsis. Am J Obstet Gynecol 1999;181:816-21.
83. Edwards RK, Locksmith GJ, Duff P. Expanded-spectrum antibiotics with preterm rupture of membranes. Obstet Gynecol 2000;96:60-4.
84. Edwards RK, Clark P, Sistrom CL, Duff P. Intrapartum antibiotic prophylaxis 1: relative effects of recommended antibiotics on gram-negative pathogens. Obstet Gynecol 2002;100:534-9.
85. Glasgow TS, Young PC, Wallin J, Kwok C, Stoddard G, Firth S, et al. Association of intrapartum antibiotic exposure and late-onset serious bacterial infections in infants. Pediatrics 2005;116:696-702.
86. Fanaro S, Chierici R, Guerrini P, Vigi V. Intestinal microflora in early infancy: composition and development. Acta Paediatr 2003;441(Suppl):48-55.
87. Walker WA. Role of nutrients and bacterial colonization in the development of intestinal host defence. J Pediatr Gastroenterol Nutr 2000;30:S2-7.
88. Newburg DS. Oligosaccharides in human milk and bacterial colonization. J Pediatr Gastroenterol Nutr 2000;30:S8-17.
89. Newburg DS. Innate immunity and human milk. J Nutr 2005;135:1308-12.
90. Chierici R, Fanaro S, Saccomandi D, Vigi V. Advances in the modulation of the microbial ecology of the gut in early infancy. Acta Paediatr 2003;441(Suppl):56-63.
91. Boehm G, Fanaro S, Jelinek J, Stahl B, Marini A. Prebiotic concept for infant nutrition. Acta Paediatr 2003;441(Suppl):64-7.
92. Miniello VL, Moro GE, Armenio L. Prebiotics in infant milk formulas: new perspectives. Acta Paediatr 2003;441(Suppl):68-76.
93. Veereman-Wauters G. Application of prebiotics in infant foods. Br J Nutr 2005;93:S57-60.
94. Zeiger RS. Food allergen avoidance in the prevention of food allergy in infants and children. Pediatrics 2003;111:1662-71.
95. Finegold SM, Sutter VL, Mathisen GE. Normal indigenous intestinal flora. In: Hentges DJ, ed. Human intestinal microflora in health and disease. New York: Academic Press 1983, pp. 3-31.
96. Hooper LV, Bry L, Falk PG, Gordon JI. Host-microbial symbiosis in the mammalian intestine: exploring an internal ecosystem. Bioessays 1998;20:336-43.
97. Goldin BR. Health benefits of probiotics. Br J Nutr 1998;80(Suppl 2):S203-7.
98. Collins MD, Gibson GR. Probiotics, prebiotics and synbiotics: approaches for modulating the microbial ecology of the gut. Am J Clin Nutr 1999;69(Suppl):1052S-1057S.
99. Isolauri E, Salminen S, Ouwehand AC. Probiotics. Best Pract Res Clin Gastroenterol 2004;18:299-313.
100. Isolauri E, Sütas Y, Kankaanpää P, Arvilommi H, Salminen S. Probiotics: effects on immunity. Am J Clin Nutr 2001;73(Suppl):444S-450S.
101. Podolski DK. Inflammatory bowel disease. N Engl Med J 2002;347:417-29.
102. Macfarlane S, Furrie E, Kennedy A, Cummings JH, Macfarlane GT. Mucosal bacteria in ulcerative colitis. Br J Nutr 2005;93(Suppl):S67-S72.
103. Langhendries JP, Detry J, Van Hees JN, Lamboray JM, Darimont J, Mozin MJ, et al. Effect of a fermented infant formula containing viable Bifidobacteria on the fecal flora composition and Ph of healthy full-term infants. J Pediatr Gastroenterol Nutr 1995;21:177-81.
104. Rinne M, Kalliomaki M, Arvilommi H, Salminen S, Isolauri E. Effects of probiotics and breastfeeding on the Bifidobacterium and Lactobacillus/ Enterococcus microbiotia and humoral responses. J Pediatr 2005;147:186-91.
105. Lin HC, Su BH, Chen AC, Lin TW, Tsai CH, Yeh TF, et al. Oral probiotics reduce the incidence and severity of necrotizing enterocolitis in very low birthweight infants. Pediatrics 2005;115:1-4.
106. Bin-Nun A, Bromiker R, Wilschanski M, Kaplan M, Rudenski B, Caplan M, et al. Oral probiotics prevent necrotizing in very low birth weight infants. J Pediatr 2005;147:192-6.
107. Dani C, Biadaioli R, Bertini G, Martelli E, Rubaltelli FF. Probiotics feeding in prevention of urinary tract infection, bacterial sepsis and necrotizing enterocolitis in preterm infants. A prospective double-blind study. Biol Neonate 2002;82:103-8.
108. Marini A, Negretti F, Boehm G, Li Destri M, Clerici-Bagozzi D, Mosca F, et al. Pro-and pre-biotics administration in preterm infants: colonization and influence of faecal flora. Acta Paediatr 2003;441(Suppl):80-1.
109. Biancone L, Monteleone I, Del Vecchio Blanco G, Vavassori P, Pallone F. Resident bacterial flora and immune system. Dig Liver Dis 2002;34(Suppl 2):S37-43.
110. Guarner F. The intestinal flora in inflammatory bowel disease: normal or abnormal? Curr Opin Gastroenterol 2005;21:414-8.