History of oral tolerance and mucosal immunity

Annals of the New York Academy of Sciences

Volumn 778, Issue , 1996, Pages 1-27

  Brandtzaeg, Per ^a  

^a UNIVERSITY OF OSLO   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN A; IMMUNOGLOBULIN E; IMMUNOGLOBULIN M; IMMUNOGLOBULIN RECEPTOR; SECRETORY IMMUNOGLOBULIN;

ALLERGY; ANTIBODY RESPONSE; AUTOIMMUNITY; HUMAN; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOLOGICAL TOLERANCE; IMMUNOMODULATION; IMMUNOSTIMULATION; INTESTINE MUCOSA; LYMPHOID CELL; NONHUMAN; PEYER PATCH; REVIEW; VACCINATION;

EID: 0029883626     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1996.tb21110.x     Document Type: Review

References (121)

1. HANSON, L. Å., R. ASHRAF, B. CARLSSON, F. JALIL, J. KARLBERG, B. S. LINDBLAD, S. R. KHAN & S. ZAMAN. 1993. Child health and the population increase. In Peace, Health and Development. L. Å. Hanson & L. Köhler, Eds. 4: 31-38.
2. BRANDTZAEG, P. 1995. The SMI-an international society for mucosal immunology. Immunologist 3: 67-69.
3. MESTECKY, J. & J. R. MCGHEE. 1989. Oral immunization: past and present. Curr. Top. Microbiol. Immunol. 146: 3-11.
4. BIENENSTOCK, J. 1991. A non-historical overview of mucosal immunology. In Frontiers of Mucosal Immunology. Proc. Sixth Int. Congr. Mucosal Immunology. M. Tsuchiya, H. Nagura, T. Hibi & I. Moro, Eds.: XV-XViii. Excerpta Medica, Elsevier (Biomed. Div.). Amsterdam.
5. PEYER, J. C. 1677. Exercitatio anatomico-medica de glandulis intestinorum. Schaffhausen. Switzerland.
6. BRANDTZAEG, P., D. E. NILSSEN, T. O. ROGNUM & P. S. THRANE. 1991. Ontogeny of the mucosal immune system and IgA deficiency. Gastroenterol. Clin. North Am. 20: 397-439.
7. BRANDTZAEG, P. 1995. Molecular and cellular aspects of the secretory immunoglobulin system. APMIS 103: 1-19.
8. BRANDTZAEG, P. 1995. Basic mechanisms of mucosal immunity - a major adaptive defense system. Immunologist 3: 89-96.
9. KUPER, C. F., P. J. KOORNSTRA, D. M. HAMELEERS, J. BJEWENGA, B. J. SPIT, A. M. DUIJVESTIJN, P. J. VAN BREDA VRIESMAN & T. SMINIA. 1992. The role of nasopharyngeal lymphoid tissue. Immunol. Today 13: 219-224.
10. BRANDTZAEG, P. & T. S. HALSTENSEN. 1992. Immunology and immunopathology of tonsils. Adv. Oto-rhino-laryngol. 7: 64-75.
11. MCDERMOTT, M. R. & J. BIENENSTOCK. 1979. Evidence for a common mucosal immunologic system. I. Migration of B immunoblasts into intestinal, respiratory, and genital tissues. J. Immunol. 122: 1892-1898.
12. MESTECKY, J., R. ABRAHAM & P. L. OGRA. 1994. Common mucosal immune system and strategies for the development of vaccines effective at the mucosal surfaces. In Handbook of Mucosal Immunology. P. L. Ogra, J. Mestecky, M. E. Lamm, W. Strober, J. R. McGhee & J. Bienenstock, Eds.: 357-372. Academic Press. Orlando, Florida.
13. BRANDTZAEG, P. 1992. Humoral immune response patterns of human mucosae: induction and relation to bacterial respiratory tract infections. J. Infect. Dis. 165: Suppl. 1: S167-176.
14. VANCOTT, J. L., T. A. BRIM, J. K. LUNNEY & L. J. SAIF. 1994. Contribution of antibody-secreting cells induced in mucosal lymphoid tissues of pigs inoculated with respiratory or enteric strains of coronavirus to immunity against enteric coronavirus challenge. J. Immunol. 152: 3980-3990.
15. BRANDTZAEG, P., K. BAKLIEN, K. BJERKE, T. O. ROGNUM, H. SCOTT & K. VALNES. 1987. Nature and properties of the human gastrointestinal immune system. In Immunology of the Gastrointestinal Tract. K. Miller & S. Nicklin, Eds.: 1-86. CRC Press. Boca Raton, Florida.
16. KATO, T. & R. L. OWEN. 1994. Structure and function of intestinal mucosal epithelium. In Handbook of Mucosal Immunology. P. L. Ogra, J. Mestecky, M. E. Lamm, W. Strober, J. R. McGhee & J. Bienenstock, Eds.: 11-26. Academic Press. Orlando, Florida.
17. FARSTAD, I. N., T. S. HALSTENSEN, O. FAUSA & P. BRANDTZAEG. 1994. Heterogeneity of M-cell-associated B and T cells in human Peyer's patches. Immunology 83: 457-464.
18. LINDNER, J., A. F. GECZY & G. J. RUSSELL-JONES. 1994. Identification of the site of uptake of the E. coli heat-labile enterotoxin, LTB. Scand. J. Immunol. 40: 564-572.
19. TROWELL, O. A. 1958. The lymphocyte. Int. Rev. Cytol. 7: 235-293.
20. YOFFEY, J. M. 1966. Lymphocytes - the fourth circulation. Discovery 27: 24-29.
21. GOWANS, J. L. & E. J. KNIGHT. 1964. The route of re-circulation of lymphocytes in the rat. Proc. R. Soc. (Lond.) B159: 257-282.
22. CRAIG, S. W. & J. J. CEBRA. 1971. Payer's patches: an enriched source of precursors for IgA-producing immunocytes in the rabbit. J. Exp. Med. 134: 188-200.
23. DUIJVESTIJN, A. & A. HAMANN. 1989. Mechanisms and regulation of lymphocyte migration. Immunol. Today 10: 23-28.
24. SALMI, M. & S. JALKANEN. 1991. Regulation of lymphocyte traffic to mucosa-associated lymphatic tissues. Gastroenterol. Clin. North Am. 20: 495-510.
25. PICKER, L. J. 1994. Control of lymphocyte homing. Curr. Opinion Immunol. 6: 394-406.
26. FARSTAD, I. N., T. S. HALSTENSEN, A. I. LAZAROVITS, J. NORSTEIN, O. FAUSA & P. BRANDTZAEG. 1995. Human intestinal B-cell blasts and plasma cells express the mucosal homing receptor integrin α4β7. Scand. J. Immunol. In press.
27. CEPEK, K. L., S. K. SHAW, C. M. PARKER, G. J. RUSSELL, J. S. MORROW, D. L. RIMM & M. B. BRENNER. 1994. Adhesion between epithelial cells and T lymphocytes mediated by E-cadherin and the α4β7 integrin. Nature 372: 190-193.
28. PABST, R. & I. GEHRKE. 1990. Is the bronchus-associated lymphoid tissue (BALT) an integral structure of the lung in normal mammals, including humans? Am. J. Respir. Cell. Mol. Biol. 3: 131-135.
29. CZERKINSKY, C. & J. HOLMGREN. 1995. The mucosal immune system and prospects for anti-infectious and anti-inflammatory vaccines. Immunologist 3: 97-103.
30. GORDON, B. L. 1945. The Romance of Medicine. The Story of the Evolution of Medicine from Occult Practices and Primitive Times. In Anonymous pp. 395-398. Davis Co. Philadelphia.
31. BRANDTZAEG, P., T. S. HALSTENSEN, K. KETT, P. KRAJČI, D. KVALE, T. O. ROGNUM, H. SCOTT & L. M. SOLLID. 1989. Immunobiology and immunopathology of human gut mucosa: humoral immunity and intraepithelial lymphocytes. Gastroenterology 97: 1562-1584.
32. BESREDKA, A. 1919. De la vaccination contre les états typhoides par la voie buccale. Ann. Inst. Pasteur 33: 882-903.
33. DAVIES, A. 1922. An investigation into the serological properties of dysentery stools. Lancet ii: 1009-1012.
34. HANSON, L. A. & P. BRANDTZAEG. 1993. The discovery of secretory IgA and the mucosal immune system. Immunol. Today 14: 416-417.
35. TOMASI, T. B., E. M. TAN, A. SOLOMON & R. A. PRENDERGAST. 1965. Characteristics of an immune system common to certain external secretions. J. Exp. Med. 121: 101-124.
36. BRANDTZAEG, P. 1985. Role of J chain and secretory component in receptor-mediated glandular and hepatic transport of immunoglobulins in man. Scand. J. Immunol. 22: 111-146.
37. BRANDTZAEG, P., I. FJELLANGER & S. T. GJERULDSEN. 1970. Human secretory immunoglobulins. I. Salivary secretions from individuals with normal or low levels of serum immunoglobulins. Scand. J. Haematol. Suppl. 12: 3-83.
38. BRANDTZAEG, P., I. FJELLANGER & S. T. GJERULDSEN. 1968. Immunoglobulin M: local synthesis and selective secretion in patients with immunoglobulin A deficiency. Science 160: 789-791.
39. BRANDTZAEG, P. 1975. Human secretory immunoglobulin M. An immunochemical and immunohistochemical study. Immunology 29: 559-570.
40. BRANDTZAEG, P. 1973. Two types of IgA immunocytes in man. Nature New Biol. 243: 142-143.
41. BRANDTZAEG, P. 1974. Mucosal and glandular distribution of immunoglobulin components: differential localization of free and bound SC in secretory epithelial cells. J. Immunol. 112: 1553-1559.
42. HALPERN, M. S. & M. E. KOSHLAND. 1970. Novel subunit in secretory IgA. Nature 228: 1276-1278.
43. MESTECKY, J., J. ZIKAN & W. T. BUTLER. 1971. Immunoglobulin M and secretory immunoglobulin A: presence of a common polypeptide chain different from light chains. Science 171: 1163-1165.
44. SINGER, S. J. & G. L. NICHOLSON. 1972. The fluid mosaic model of the structure of cell membranes. Science 175: 720-731.
45. MACH, J. P. 1970. In vitro combination of human and bovine free secretory component with IgA of various species. Nature 228: 1278-1282.
46. RADL, J., F. KLEIN, P. VAN DEN BERG, A. M. DE BRUYN & W. HUMANS. 1971. Binding of secretory piece to polymeric IgA and IgM paraproteins in vitro. Immunology 20: 843-852.
47. BRANDTZAEG, P. 1974. Presence of J chain in human immunocytes containing various immunoglobulin classes. Nature 252: 418-420.
48. ESKELAND, T. & P. BRANDTZAEG. 1974. Does J Chain mediate the combination of 19S IgM and dimeric IgA with the secretory component rather than being necessary for their polymerization? Immunochemistry 11: 161-163.
49. BAKOS, M. A., A. KUROSKY & R. M. GOLDBLUM. 1991. Characterization of a critical binding site for human polymeric Ig on secretory component. J. Immunol. 151: 3419-3426.
50. COYNE, R. S., M. SIEBRECHT, M. C. PEITSCH & J. E. CASANOVA. 1994. Mutational analysis of polymeric immunoglobulin receptor/ligand interactions. Evidence for the involvement of multiple complementarity determining region (CDR)-like loops in receptor domain I. J. Biol. Chem. 269: 31620-31625.
51. BRANDTZAEG, P., P. KRAJČI, M. E. LAMM & C. S. KAETZEL. 1994. Epithelial and hepatobiliary transport of polymeric immunoglobulins. In Handbook of Mucosal Immunology. P. L. Ogra, J. Mestecky, M. E. Lamm, W. Strober, J. R. McGhee & J. Bienenstock, Eds.: 113-126. Academic Press. Orlando, Florida.
52. BRANDTZAEG, P. & H. PRYDZ. 1984. Direct evidence for an integrated function of J chain and secretory component in epithelial transport of immunoglobulins. Nature 311: 71-73.
53. MOSTOV, K. E. 1994. Transepithelial transport of immunoglobulins. Annu. Rev. Immunol. 12: 63-84.
54. MOSTOV, K. E., J. P. KRAEHENBUHL & G. BLOBEL. 1980. Receptor-mediated transcellular transport of immunoglobulin: synthesis of secretory component as multiple and larger transmembrane forms. Proc. Natl. Acad. Sci. USA 77: 7257-7261.
55. MOSTOV, K. E., M. FREDLANDER & G. BLOBEL. 1984. The receptor for transepithelial transport of IgA and IgM contains multiple immunoglobulin-like domains. Nature 308: 37-43.
56. EIFFERT, H., E. QUENTIN, J. DECKER, S. HILLEMEIR, M. HUFSCHMIDT, D. KLINGMÜLLER, M. H. WEBER & N. HILSCHMANN. 1984. Die Primärstruktur der menschlichen freien Sekretkomponente und die Anordnung der Disulfidbrücken. Hoppe-Seyler's Z. Physiol. Chem. 365: 1489-1495.
57. KRAJČI, P., K. H. GRZESCHIK, A. H. GEURTS VAN KESSEL, B. OLAISEN & P. BRANDTZAEG. 1991. The human transmembrane secretory component (poly-Ig receptor): molecular cloning, restriction fragment length polymorphism and chromosomal sublocalization. Hum. Genet. 87: 642-648.
58. KRAJČI, P., D. KVALE, K. TASKEN & P. BRANDTZAEG. 1992. Molecular cloning and exon-intron mapping of the gene encoding human transmembrane secretory component (the poly-Ig receptor). Eur. J. Immunol. 22: 2309-2315.
59. BANTING, G., B. BRAKE, P. BRAGHETTA, J. P. LUZIO & K. K. STANLEY. 1989. Intracellular targeting signals of polymeric immunoglobulin receptors are highly conserved between species. FEBS Lett. 254: 177-183.
60. PISKURICH, J. F., M. H. BLANCHARD, K. R. YOUNGMAN, J. A. FRANCE & C. S. KAETZEL. 1995. Molecular cloning of the mouse polymeric Ig receptor. Functional regions of the molecule are conserved among five mammalian species. J. Immunol. 154: 1735-1747.
61. KULSETH, M. A., P. KRAJČI, O. MYKLEBOST & S. ROGNE. 1995. Cloning and characterization of two forms of bovine polymeric immunoglobulin receptor cDNA. DNA Cell Biol. 14: 251-256.
62. KVALE, D. & P. BRANDTZAEG. 1995. Constitutive and cytokine induced expression of HLA molecules, secretory component, and intercellular adhesion molecule-1 is modulated by butyrate in the colonic epithelial cell line HT-29. Gut 36: 737-742.
63. BRANDTZAEG, P., T. S. HALSTENSEN, H. S. HUITFELDT, P. KRAJČI, D. KVALE, H. SCOTT & P. S. THRANE. 1992. Epithelial expression of HLA, secretory component (poly-Ig receptor), and adhesion molecules in the human alimentary tract. Ann. N. Y. Acad. Sci. 664: 157-179.
64. FERGUSON, A. 1977. Intraepithelial lymphocytes of the small intestine. Gut 18: 921-937.
65. CERF-BENSUSSAN, N., M. CERF & D. GUY-GRAND. 1993. Gut intraepithelial lymphocytes and gastrointestinal diseases. Curr. Opinion Gastroenterol. 9: 953-961.
66. HALSTENSEN, T. S. & P. BRANDTZAEG. 1994. Phenotypic characteristics of human intraepithelial lymphocytes. In Mucosal Immunology: Intraepithelial Lymphocytes. Advances in Host Defense Mechanisms. H. Kiyono & J. R. McGhee, Eds.: 147-161. Raven Press. New York.
67. BLUMBERG, R. S. & S. P. BALK. 1994. Intraepithelial lymphocytes and their recognition of non-classical MHC molecules. Int. Rev. Immunol. 11: 15-30.
68. 2-microglobulin-independent MHC class Ib molecule expressed by human intestinal epithelium. Science 265: 259-262.
69. VIDAL, K., C. SAMARUT, J.-P. MAGAUD, J.-P. REVILLARD & D. KAISERLIAN. 1993. Unexpected lack of reactivity of allogeneic anti-Ia monoclonal antibodies with MHC class II molecules expressed by mouse intestinal epithelial cells. J. Immunol. 151: 4642-4650.
70. BORN, W., M. P. HAPP, A. DALLAS, C. REARDON, R. KUBO, T. SHINNICK, P. BRENNAN & R. O'BRIEN. 1990. Recognition of heat shock proteins and γδ cell function. Immunol. Today 11: 40-43.
71. ERLE, D. J. 1995. Scratching the surface. Curr. Biol. 5: 252-254.
72. KLEIN, J. R. & M. HAMAD. 1995. γδ T cells, antigen recognition and intestinal immunity. Immunol. Today 16: 108-109.
73. KIYONO, H. & J. R. MCGHEE. 1994. T helper cells for mucosal immune responses. In Handbook of Mucosal Immunology. P. L. Ogra, J. Mestecky, M. E. Lamm, W. Strober, J. R. McGhee & J. Bienenstock, Eds.: 263-274. Academic Press. Orlando, Florida.
74. BRANDTZAEG, P., T. S. HALSTENSEN, M. HVATUM, D. KVALE & H. SCOTT. 1993. The serologic and mucosal immunologic basis of celiac disease. In Immunophysiology of the Gut. Bristol-Myers Squibb/Mead Johnson Nutrition Symposia. W. A. Walker, P. R. Harmatz & B. K. Wershil, Eds.: 295-333. Academic Press. London.
75. MCMENAMIN, C., C. PIMM, M. MCKERSEY & P. G. HOLT. 1994. Regulation of IgE responses to inhaled antigen in mice by antigen-specific γδ T cells. Science 265: 1869-1871.
76. DAKIN, R. 1829. Remarks on a cutaneous affection, produced by certain poisonous vegetables. Am. J. Med. Sci. 4: 98-100.
77. MOWAT, A. M. 1994. Oral tolerance and regulation of immunity to dietary antigens. In Handbook of Mucosal Immunology. P. L. Ogra, J. Mestecky, M. E. Lamm, W. Strober, J. R. McGhee & J. Bienenstock, Eds.: 185-201. Academic Press. Orlando, Florida.
78. JOHNSON, R. B., J. T. LABROOY & J. H. SKERRITT. 1990. Antibody responses reveal differences in oral tolerance to wheat and maize grain protein fractions. Clin. Exp. Immunol. 79: 135-140.
79. DE AIZPURUA, H. J. & G. J. RUSSELL-JONES. 1988. Oral vaccination. Identification of classes of proteins that provoke an immune response upon oral feeding. J. Exp. Med. 167: 440-451.
80. DAHLGREN, U. I. H., A. E. WOLD, L. Å. HANSON & T. MIDTVEDT. 1991. Expression of a dietary protein in E. coli renders it strongly antigenic to gut lymphoid tissue. Immunology 73: 394-397.
81. PENG, H.-J., Z.-N. CHANG, S.-H. HAN, M.-H. WON & B.-T. HUANG. 1995. Chemical denaturation of ovalbumin abrogates the induction of oral tolerance of specific IgG antibody and DTH responses in mice. Scand. J. Immunol. 42: 297-304.
82. HÖRNQUIST, C. E., K. D. GRDIC, T. W. MAY & N. LYCKE. 1994. Augmented mucosal immune responses and intact adjuvant effects of cholera toxin in CD8- but not in CD4-deficient mice. Immunology. In press.
83. NICKOLOFF, B. J. & L. A. TURKA. 1994. Immunological functions of non-professional antigen-presenting cells: new insights from studies of T-cell interactions with keratinocytes. Immunol. Today 15: 464-469.
84. MATZINGER, P. 1994. Tolerance, danger, and the extended family. Annu. Rev. Immunol. 12: 991-1045.
85. ROTHBERG, R. M. & R. S. FARR. 1965. Anti-bovine serum albumin and anti-alpha lactalbumin in the serum of children and adults. Pediatrics 35: 571-588.
86. SCOTT, H., T. O. ROGNUM, T. MIDTVEDT & P. BRANDTZAEG. 1985. Age-related changes of human serum antibodies to dietary and colonic bacterial antigens measured by an enzyme-linked immunosorbent assay. Acta Pathol. Microbiol. Immunol. Scand. [C] 93: 65-70.
87. KORENBLAT, P. E., R. M. ROTHBERG, P. MINDEN & R. S. FARR. 1968. Immune responses of human adults after oral and parenteral exposure to bovine serum albumin. J. Allergy 41: 226-235.
88. HUSBY, S., J. MESTECKY, Z. MOLDOVEANU, S. HOLLAND & C. O. ELSON. 1994. Oral tolerance in humans. T cell but not B cell tolerance after antigen feeding. J. Immunol. 152: 4663-4670.
89. WALDO, F. B., A. W. VAN DEN WALL BAKE, J. MESTECKY & S. HUSBY. 1994. Suppression of the immune response by nasal immunization. Clin. Immunol. Immunopathol. 72: 30-34.
90. SACHDEV, G. K., H. R. DALTON, P. HOANG, M.-C. DIPAOLO, B. CROTTY & D. P. JEWELL. 1993. Human colonic intraepithelial lymphocytes suppress in vitro immunoglobulin synthesis by autologous peripheral blood lymphocytes and lamina propria lymphocytes. Gut 34: 257-263.
91. HOYNE, G. F., M. G. CALLOW, M. C. KUO & W. R. THOMAS. 1993. Presentation of peptides and proteins by intestinal epithelial cells. Immunology 80: 204-208.
92. JENKINS, M. K. 1992. The role of cell division in the induction of clonal anergy. Immunol. Today 13: 69-73.
93. SCHWARTZ, R. H. 1990. A cell culture model for T lymphocyte clonal anergy. Science 248: 1349-1356.
94. DURIE, F. H., T. M. FOY, S. R. MASTERS, J. D. LAMAN & R. J. NOELLE. 1994. The role of CD40 in the regulation of humoral and cell-mediated immunity. Immunol. Today 15: 406-411.
95. NICKLIN, S. & K. MILLER. 1983. Local and systemic immune responses to intestinally presented antigen. Int. Arch. Allergy Appl. Immunol. 72: 87-90.
96. STROBEL, S., A. M. MOWAT, H. E. DRUMMOND, M. G. PICKERING & A. FERGUSON. 1983. Immunological responses to fed protein antigens in mice. II. Oral tolerance for CMI is due to activation of cyclophosphamide-sensitive cells by gut-processed antigen. Immunology 49: 451-456.
97. PANJA, A., R. S. BLUMBERG, S. P. BALK & L. MAYER. 1993. CD1d is involved in T cell-intestinal epithelial cell interactions. J. Exp. Med. 178: 1115-1119.
98. lck. J. Exp. Med. 182: 1079-1088.
99. + suppressor T lymphocytes. J. Immunol. 142: 3731-3739.
100. + cells. J. Immunol. 145: 1646-1652.
101. HOLT, P. G. & C. MCMENAMIN. 1989. Defence against allergic sensitization in the healthy lung: the role of inhalation tolerance. Clin. Exp. Allergy 19: 255-262.
102. + T cell-dependent immune deviation resulting in selective suppression of immunoglobulin E production. J. Exp. Med. 178: 889-899.
103. HOLT, P. G. 1994. Immunoprophylaxis of atopy: light at the end of the tunnel? Immunol. Today 15: 484-489.
104. BRANDTZAEG, P. 1995. Immunocompetent cells of the upper airway: functions in normal and diseased mucosa. Eur. Oto-rhino-laryngol. 252(Suppl. 1): S8-S21.
105. GRABBE, S., S. BEISSERT, T. SCHWARZ & R. D. GRANSTEIN. 1995. Dendritic cells as initiators of tumor immune responses: a possible strategy for tumor immunotherapy? Immunol. Today 16: 117-121.
106. KALB, T. H., M. T. CHUANG, Z. MAROM & L. MAYER. 1991. Evidence for accessory cell function by class IIMHC antigen-expressing airway epithelial cells. Am. J. Respir. Cell. Mol. Biol. 4: 320-329.
107. MCWILLIAM, A. S., D. NELSON, J. A. THOMAS & P. G. HOLT. 1994. Rapid dendritic cell recruitment is a hallmark of the acute inflammatory response at mucosal surfaces. J. Exp. Med. 179: 1331-1336.
108. MACPHERSON, G. G., C. D. JENKINS, M. J. STEIN & C. EDWARDS. 1995. Endotoxin-mediated dendritic cell release from the intestine. Characterization of released dendritic cells and TNF dependence. J. Immunol. 154: 1317-1322.
109. STINGL, G. & P. R. BERGSTRESSER. 1995. Dendritic cells: a major story unfolds. Immunol. Today 16: 330-333.
110. YSSEL, H., S. FASLER, J. LAMB & J. E. DE VRIES. 1994. Induction of non-responsiveness in human allergen-specific type 2 T helper cells. Curr. Opinion Immunol. 6: 847-852.
111. HOLT, P. G. 1994. A potential vaccine strategy for asthma and allied atopic diseases during early childhood. Lancet 344: 456-458.
112. VAN HOOGSTRATEN, I. M. W., K. E. ANDERSEN, B. M. E. VON BLOMBERG, D. BODEN, D. P. BRUYNZEEL, D. BURROWS, J. G. CAMARASA, A. DOOMS-GOOSSENS, G. KRAAL, A. LAHTI et al. 1991. Reduced frequency of nickel allergy upon oral nickel contact at an early age. Clin. Exp. Immunol. 85: 441-445.
113. VAN HOOGSTRATEN, I. M. W., C. BOOS, D. BODEN, M. E. VON BLOMBERG, R. J. SCHEPER & G. KRAAL. 1993. Oral induction of tolerance to nickel sensitization in mice. J. Invest. Dermatol. 101: 26-31.
114. WETNER, H. L., A. FRIEDMAN, A. MILLER, S. J. KHOURY, A. AL-SABBAGH, L. SANTOS, M. SAYEGH, R. B. NUSSENBLATT, D. E. TRENTHAM & D. A. HAFLER. 1994. Oral tolerance: immunologic mechanisms and treatment of animal and human organ-specific autoimmune diseases by oral administration of autoantigens. Annu. Rev. Immunol. 12: 809-837.
115. PLANCHON, S. M., C. A. P. MARTINS, R. L. GUERRANT & J. K. ROCHE. 1994. Regulation of intestinal epithelial barrier function by TGF-β1: Evidence for its role in abrogating the effect of a T cell cytokine. J. Immunol. 153: 5730-5739.
116. STOK, W., P. J. VAN DER HEIJDEN & A. T. J. BIANCHI. 1994. Conversion of orally induced suppression of the mucosal immune response to ovalbumin into stimulation by conjugating ovalbumin to cholera toxin or its B subunit. Vaccine 12: 521-526.
117. BAZIN, H. 1976. The secretory antibody system. In Immunological Aspects of the Liver and Gastrointestinal Tract. A. Ferguson & R. N. M. MacSween, Eds.: 33-82. MTP Press Ltd. Lancaster, England.
118. STROBEL, S. 1995. Development of oral tolerance. In Intestinal Immunology and Food Allergy. A. de Weck & H. A. Sampson, Eds.: Vol. 34. Nestle Nutrition Workshop Series. 155-166. Nestec Ltd., Vevey/Raven Press, Ltd. New York.
119. ROGOFF, T. M. & P. E. LIPSKY. 1981. Role of the Kupffer cells in local and systemic immune responses. Gastroenterology 80: 854-860.
120. DUMONT, A. E. 1979. Orally induced tolerance. J. Immunol. 122: 2134-2135.
121. GABORIAU-ROUTHIAU, V. & M.-C. MOREAU. 1996. The gut flora allows recovery of oral tolerance to ovalbumin after a transient breakdown mediated by cholera toxin or Escherichia coli heat-labile enterotoxin in mice. Pediatr. Res. In press.