Intracellular uptake of thymidine and antiherpetic drugs for thymidine kinase-deficient mutants of herpes simplex virus type 1

Antiviral Research

Volumn 70, Issue 3, 2006, Pages 93-104

  Bae, Pan Kee ^a   Kim, Jee Hyun ^a   Kim, Hae Soo ^a   Chung, In Kwon ^b   Paik, Sang Gi ^c   Lee, Chong Kyo ^a  

^a Korea Research Institute of Chemical Technology   (South Korea)

^b Yonsei University   (South Korea)

^c Chungnam National University   (South Korea)

Author keywords

Antiherpetic drug; Drug resistance; Herpes simplex virus; Nucleoside anabolism; Nucleoside uptake; Thymidine kinase; TK deficiency

Indexed keywords

ACICLOVIR; ANTIVIRUS AGENT; GANCICLOVIR; NUCLEOSIDE DERIVATIVE; PENCICLOVIR; RECOMBINANT ENZYME; THYMIDINE KINASE; VIRUS DNA;

ARTICLE; AUTORADIOGRAPHY; BIOSYNTHESIS; CELL CULTURE; CELL LINE; CONTROLLED STUDY; DRUG EFFECT; DRUG INHIBITION; DRUG METABOLISM; DRUG UPTAKE; ENZYME ACTIVITY; ENZYME DEFICIENCY; ENZYME SPECIFICITY; GENETIC ANALYSIS; GENOTYPE; HERPES SIMPLEX VIRUS 1; MOLECULAR CLONING; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; VERO CELL; VIRUS MUTANT; VIRUS REPLICATION; VIRUS STRAIN;

ACYCLOVIR; ANIMALS; ANTIVIRAL AGENTS; CELL LINE, TUMOR; CERCOPITHECUS AETHIOPS; DNA; DNA, VIRAL; DRUG RESISTANCE, VIRAL; GANCICLOVIR; HERPESVIRUS 1, HUMAN; HUMANS; MUTATION; SUBSTRATE SPECIFICITY; THYMIDINE; THYMIDINE KINASE; VERO CELLS;

HUMAN HERPESVIRUS 1;

EID: 33646759593     PISSN: 01663542     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.antiviral.2006.01.010     Document Type: Article

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