Meta-analysis of the use of rescue antiemetics following PONV prophylactic failure with 5-HT3 antagonist/dexamethasone versus single-agent therapies

Annals of Pharmacotherapy

Volumn 40, Issue 5, 2006, Pages 873-887

  Kovac, Anthony L ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

5 HT3; Dolasetron; Granisetron; Ondansetron; Postoperative nausea and vomiting

Indexed keywords

ANTIEMETIC AGENT; DEXAMETHASONE; DOLASETRON MESILATE; GRANISETRON; ONDANSETRON; PLACEBO; SEROTONIN 3 ANTAGONIST; TROPISETRON;

ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; DRUG SAFETY; HIGH RISK PATIENT; HUMAN; INCIDENCE; META ANALYSIS; MONOTHERAPY; POSTOPERATIVE COMPLICATION; POSTOPERATIVE NAUSEA AND VOMITING; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SYSTEMATIC REVIEW; TREATMENT OUTCOME;

ANTIEMETICS; DEXAMETHASONE; DRUG THERAPY, COMBINATION; HUMANS; POSTOPERATIVE NAUSEA AND VOMITING; RANDOMIZED CONTROLLED TRIALS; RECEPTORS, SEROTONIN, 5-HT3; TREATMENT FAILURE;

EID: 33646758512     PISSN: 10600280     EISSN: None     Source Type: Journal    
DOI: 10.1345/aph.1G338     Document Type: Article

References (87)

1. Fortier J, Chung F, Su J. Unanticipated admission after ambulatory surgery-a prospective study. Can J Anaesth 1998;45:612-9.
2. Gold BS, Kitz DS, Lecky JH, Neuhaus JM. Unanticipated admission to the hospital following ambulatory surgery. JAMA 1989;262:3008-10.
3. Watcha MF, White PF. Postoperative nausea and vomiting. Its etiology, treatment, and prevention. Anesthesiology 1992;77:162-84.
4. Kovac AL. Prevention and treatment of postoperative nausea and vomiting. Drugs 2000;59:213-43.
5. Higgins GA, Kilpatrick GJ, Bunce KT, Jones BJ, Tyers MB. 5-HT3 receptor antagonists injected into the area postrema inhibit cisplatin-induced emesis in the ferret. Br J Pharmacol 1989;97:247-55.
6. 3 receptors. Br J Pharmacol 1988;94:397-412.
7. Pearman MH. Single dose intravenous ondansetron in the prevention of postoperative nausea and vomiting. Anaesthesia 1994;49(suppl):11-5.
8. Apfel CC, Korttila K, Abdalla M, et al. A factorial trial of six interventions for the prevention of postoperative nausea and vomiting. N Engl J Med 2004;350:2441-51.
9. Kovac AL, O'Connor TA, Pearman MH, et al. Efficacy of repeat intravenous dosing of ondansetron in controlling postoperative nausea and vomiting: a randomized, double-blind, placebo-controlled multicenter trial. J Clin Anesth 1999;11:453-9.
10. Suen TK, Gin TA, Chen PP, Rowbottom YM, Critchley LA, Ray AK. Ondansetron 4 mg for the prevention of nausea and vomiting after minor laparoscopic gynaecological surgery. Anaesth Intensive Care 1994;22:142-6.
11. Kreisler NS, Spiekermann BF, Ascari CM, et al. Small-dose droperidol effectively reduces nausea in a general surgical adult patient population. Anesth Analg 2000;91:1256-61.
12. Fortney JT, Gan TJ, Graczyk S, et al. A comparison of the efficacy, safety, and patient satisfaction of ondansetron versus droperidol as antiemetics for elective outpatient surgical procedures. S3A-409 and S3A-410 Study Groups. Anesth Analg 1998;86:731-8.
13. White PF, Watcha MF. Postoperative nausea and vomiting: prophylaxis versus treatment. Anesth Analg 1999;89:1337-9.
14. Tramer MR, Reynolds DJ, Moore RA, McQuay HJ. Efficacy, dose-response, and safety of ondansetron in prevention of postoperative nausea and vomiting: a quantitative systematic review of randomized placebo-controlled trials. Anesthesiology 1997;87:1277-89.
15. Figueredo ED, Canosa LG. Ondansetron in the prophylaxis of postoperative vomiting: a meta-analysis. J Clin Anesth 1998;10:211-21.
16. Tramer MR. A rational approach to the control of postoperative nausea and vomiting: evidence from systematic reviews. Part I. Efficacy and harm of antiemetic interventions, and methodological issues. Acta Anaesthesiol Scand 2001;45:4-13.
17. Gupta A, Wu CL, Elkassabany N, Krug CE, Parker SD, Fleisher LA. Does the routine prophylactic use of antiemetics affect the incidence of postdischarge nausea and vomiting following ambulatory surgery?: a systematic review of randomized controlled trials. Anesthesiology 2003;99:488-95.
18. Kazemi-Kjellberg F, Henzi I, Tramer MR. Treatment of established postoperative nausea and vomiting: a quantitative systematic review. BMC Anesthesiol 2001;1:2.
19. Eberhart LH, Morin AM, Hoerle S, Wulf H, Geldner G. Droperidol and dolasetron alone or in combination for prevention of postoperative nausea and vomiting after vitrectomy. Ophthalmology 2004;111:1569-75.
20. Loewen P, Lamb S, Clugston P. Randomized, double-blind trial of dolasetron versus droperidol for prophylaxis of postoperative nausea and vomiting in patients undergoing TRAM flap breast reconstruction surgery. Ann Plast Surg 2003;51:472-7.
21. Awad IT, Murphy D, Stack D, Swanton BJ, Meeke RI, Shorten GD. A comparison of the effects of droperidol and the combination of droperidol and ondansetron on postoperative nausea and vomiting for patients undergoing laparoscopic cholecystectomy. J Clin Anesth 2002;14:481-5.
22. Fabling JM, Gan TJ, El Moalem HE, Warner DS, Borel CO. A randomized, double-blinded comparison of ondansetron, droperidol, and placebo for prevention of postoperative nausea and vomiting after supratentorial craniotomy. Anesth Analg 2000;91:358-61.
23. Reihner E, Grunditz R, Giesecke K, Gustafsson LL. Postoperative nausea and vomiting after breast surgery: efficacy of prophylactic ondansetron and droperidol in a randomized placebo-controlled study. Eur J Anaesthesiol 2000;17:197-203.
24. Peixoto AJ, Peixoto Filho AJ, Leaes LF, Celich MF, Barros MA. Efficacy of prophylactic droperidol, ondansetron or both in the prevention of postoperative nausea and vomiting in major gynaecological surgery. A prospective, randomized, double-blind clinical trial. Eur J Anaesthesiol 2000;17:611-5.
25. Fujii Y, Tanaka H, Somekawa Y. Granisetron, droperidol, and metoclopramide for the treatment of established postoperative nausea and vomiting in women undergoing gynecologic surgery. Am J Obstet Gynecol 2000;182:13-6.
26. Fujii Y, Tanaka H, Kobayashi N. Granisetron, droperidol, and metoclopramide for preventing postoperative nausea and vomiting after thyroidectomy. Laryngoscope 1999;109:664-7.
27. Fujii Y, Toyooka H, Tanaka H. Prevention of postoperative nausea and vomiting with a combination of granisetron and droperidol. Anesth Analg 1998;86:613-6.
28. Fujii Y, Toyooka H, Tanaka H. Prevention of postoperative nausea and vomiting in female patients during menstruation: comparison of droperidol, metoclopramide and granisetron. Br J Anaesth 1998;80:248-9.
29. Fujii Y, Saitoh Y, Tanaka H, Toyooka H. Prevention of PONV with granisetron, droperidol or metoclopramide in patients with postoperative emesis. Can J Anaesth 1998;45:153-6.
30. Koivuranta M, Laara E, Ranta P, Ravaska P, Alahuhta S. Comparison of ondansetron and droperidol in the prevention of postoperative nausea and vomiting after laparoscopic surgery in women. A randomised, double-blind, placebo-controlled trial. Acta Anaesthesiol Scand 1997;41:1273-9.
31. Fujii Y, Toyooka H, Tanaka H. Prevention of PONV with granisetron, droperidol and metoclopramide in female patients with history of motion sickness. Can J Anaesth 1997;44:820-4.
32. Jellish WS, Thalji Z, Fluter E, Leonetti JP. Ondansetron versus droperidol or placebo when given prophylactically for the prevention of postoperative nausea and vomiting in patients undergoing middle ear procedures. J Clin Anesth 1997;9:451-6.
33. Wrench IJ, Ward JE, Walder AD, Hobbs GJ. The prevention of postoperative nausea and vomiting using a combination of ondansetron and droperidol. Anaesthesia 1996;51:776-8.
34. Paech MJ, Lee BH, Evans SF. The effect of anaesthetic technique on postoperative nausea and vomiting after day-case gynaecological laparoscopy. Anaesth Intensive Care 2002;30:153-9.
35. Alexander R, Lovell AT, Seingry D, Jones RM. Comparison of ondansetron and droperidol in reducing postoperative nausea and vomiting associated with patient-controlled analgesia. Anaesthesia 1995;50:1086-8.
36. Fujii Y, Tanaka H, Toyooka H. Prevention of postoperative nausea and vomiting with granisetron: a randomized, double-blind comparison with droperidol. Can J Anaesth 1995;42:852-6.
37. Gan TJ, Collis R, Hetreed M. Double-blind comparison of ondansetron, droperidol and saline in the prevention of postoperative nausea and vomiting. Br J Anaesth 1994;72:544-7.
38. Habib AS, Gan TJ. Food and drug administration black box warning on the perioperative use of droperidol: a review of the cases. Anesth Analg 2003;96:1377-9.
39. 3 receptor antagonists combined with droperidol for PONV prophylaxis is similar to their combination with dexamethasone. A meta-analysis of randomized controlled trials. Can J Anaesth 2004;51:311-9.
40. Kranke P, Apfel CC, Greim CA, Roewer N. Methodological problems arising from 'serial publishing' on the effectiveness of granisetron in PONV. Br J Anaesth 1999;82:481-3.
41. Kranke P, Apfel CC, Eberhart LH, Georgieff M, Roewer N. The influence of a dominating centre on a quantitative systematic review of granisetron for preventing postoperative nausea and vomiting. Acta Anaesthesiol Scand 2001;45:659-70.
42. Apfel CC, Kranke P, Greim CA, Roewer N. Non-systematic serial publishing is not appropriate and ethically questionable. Acta Anaesthesiol Scand 1999;43:486-7.
43. Kranke P, Apfel CC, Roewer N, Fujii Y. Reported data on granisetron and postoperative nausea and vomiting by Fujii et al. are incredibly nice! Anesth Analg 2000;90:1004-7.
44. Panda NB, Bharadwaj N, Kapoor P, Chari P, Panda NK. Prevention of nausea and vomiting after middle ear surgery: combination of ondansetron and dexamethasone is the right choice. J Otolaryngol 2004;33:88-92.
45. Gan TJ, Jiao KR, Zenn M, Georgiade G. A randomized controlled comparison of electro-acupoint stimulation or ondansetron versus placebo for the prevention of postoperative nausea and vomiting. Anesth Analg 2004;99:1070-5.
46. Sinha PK, Ambesh SP. Ondansetron in prophylaxis of postoperative nausea and vomiting in patients undergoing breast surgery: a placebo-controlled double blind study. J Indian Med Assoc 2004;102:73-9.
47. Hanaoka K, Toyooka H, Kugimiya T, Ohashi Y. Efficacy of prophylactic intravenous granisetron in postoperative emesis in adults. J Anesth 2004;18:158-65.
48. Szarvas S, Chellapuri RS, Harmon DC, Owens J, Murphy D, Shorten GD. A comparison of dexamethasone, ondansetron, and dexamethasone plus ondansetron as prophylactic antiemetic and antipruritic therapy in patients receiving intrathecal morphine for major orthopedic surgery. Anesth Analg 2003;97:259-63.
49. Yuksek MS, Alici HA, Erdem AF, Cesur M. Comparison of prophylactic anti-emetic effects of ondansetron and dexamethasone in women undergoing day-case gynaecological laparoscopic surgery. J Int Med Res 2003;31:481-8.
50. Wattwil M, Thorn SE, Lovqvist A, Wattwil L, Gupta A, Liljegren G. Dexamethasone is as effective as ondansetron for the prevention of postoperative nausea and vomiting following breast surgery. Acta Anaesthesiol Scand 2003;47:823-7.
51. Tzeng JI, Chu KS, Ho ST, Cheng KI, Liu KS, Wang JJ. Prophylactic iv ondansetron reduces nausea, vomiting and pruritus following epidural morphine for postoperative pain control. Can J Anaesth 2003;50:1023-6.
52. Agarwal A, Bose N, Gaur A, Singh U, Gupta MK, Singh D. Acupressure and ondansetron for postoperative nausea and vomiting after laparoscopic cholecystectomy. Can J Anaesth 2002;49:554-60.
53. Wang JJ, Tzeng JI, Ho ST, Chen JY, Chu CC, So EC. The prophylactic effect of tropisetron on epidural morphine-related nausea and vomiting: a comparison of dexamethasone with saline. Anesth Analg 2002;94:749-53.
54. Wang JJ, Ho ST, Uen YH, et al. Small-dose dexamethasone reduces nausea and vomiting after laparoscopic cholecystectomy: a comparison of tropisetron with saline. Anesth Analg 2002;95:229-32.
55. Wang JJ, Wang PC, Liu YH, Chien CC. Low-dose dexamethasone reduces nausea and vomiting after tympanomastoid surgery: a comparison of tropisetron with saline. Am J Otolaryngol 2002;23:267-71.
56. So JB, Cheong KF, Sng C, Cheah WK, Goh P. Ondansetron in the prevention of postoperative nausea and vomiting after laparoscopic cholecystectomy: a prospective randomized study. Surg Endosc 2002;16:286-8.
57. Kathirvel S, Dash HH, Bhatia A, Subramaniam B, Prakash A, Shenoy S. Effect of prophylactic ondansetron on postoperative nausea and vomiting after elective craniotomy. J Neurosurg Anesthesiol 2001;13:207-12.
58. Fujii Y, Tanaka H, Kawasaki T. Preoperative oral granisetron for the prevention of postoperative nausea and vomiting after breast surgery. Eur J Surg 2001;167:184-7.
59. Fujii Y, Tanaka H, Kobayashi N. Granisetron/dexamethasone combination for the prevention of postoperative nausea and vomiting after thyroidectomy. Anaesth Intensive Care 2000;28:266-9.
60. Philip BK, Pearman MH, Kovac AL, et al. Dolasetron for the prevention of postoperative nausea and vomiting following outpatient surgery with general anaesthesia: a randomized, placebo-controlled study. The Dolasetron PONV Prevention Study Group. Eur J Anaesthesiol 2000;17:23-32.
61. Tsui SL, Ng KF, Wong LC, Tang GW, Pun TC, Yang JC. Prevention of postoperative nausea and vomiting in gynaecological laparotomies: a comparison of tropisetron and ondansetron. Anaesth Intensive Care 1999;27:471-6.
62. Sinha PK, Tripathi M, Ambesh SP. Efficacy of ondansetron in prophylaxis of postoperative nausea and vomiting in patients following infratentorial surgery: a placebo-controlled prospective double-blind study. J Neurosurg Anesthesiol 1999;11:6-10.
63. Fujii Y, Tanaka H, Toyooka H. Prophylactic antiemetic therapy with granisetron-dexamethasone combination in women undergoing breast surgery. Acta Anaesthesiol Scand 1998;42:1038-42.
64. Diemunsch P, Korttila K, Leeser J, et al. Oral dolasetron mesylate for prevention of postoperative nausea and vomiting: a multicenter, double-blind, placebo-controlled study. The Oral Dolasetron PONV Prevention Study Group. J Clin Anesth 1998;10:145-52.
65. Scholz J, Hennes HJ, Steinfath M, et al. Tropisetron or ondansetron compared with placebo for prevention of postoperative nausea and vomiting. Eur J Anaesthesiol 1998;15:676-85.
66. Fujii Y, Tanaka H, Toyooka H. Preoperative oral granisetron prevents postoperative nausea and vomiting. Acta Anaesthesiol Scand 1998;42:653-7.
67. McKenzie R, Riley TJ, Tantisira B, Hamilton DL. Effect of propofol for induction and ondansetron with or without dexamethasone for the prevention of nausea and vomiting after major gynecologic surgery. J Clin Anesth 1997;9:15-20.
68. Kovac AL, Scuderi PE, Boerner TF, et al. Treatment of postoperative nausea and vomiting with single intravenous doses of dolasetron mesylate: a multicenter trial. Dolasetron Mesylate PONV Treatment Study Group. Anesth Analg 1997;85:546-52.
69. Diemunsch P, D'Hollander A, Paxton L, et al. Intravenous dolasetron mesilate in the prevention of postoperative nausea and vomiting in females undergoing gynecological surgery. J Clin Anesth 1997;9:365-73.
70. Korttila K, Clergue F, Leeser J, et al. Intravenous dolasetron and ondansetron in prevention of postoperative nausea and vomiting: a multicenter, double-blind, placebo-controlled study. Acta Anaesthesiol Scand 1997;41:914-22.
71. Moens P, Levarlet M, Hendrickx P, De Guchteneere E. Single i.v. bolus dose of ondansetron in the prevention of postoperative nausea and emesis. Acta Anaesthesiol Belg 1997;48:245-50.
72. Taylor AM, Rosen M, Diemunsch PA, Thorin D, Houweling PL. A double-blind, parallel-group, placebo-controlled, dose-ranging, multicenter study of intravenous granisetron in the treatment of postoperative nausea and vomiting in patients undergoing surgery with general anesthesia. J Clin Anesth 1997;9:658-63.
73. Wilson AJ, Diemunsch P, Lindeque BG, et al. Single-dose i.v. granisetron in the prevention of postoperative nausea and vomiting. Br J Anaesth 1996;76:515-8.
74. Lopez-Olaondo L, Carrascosa F, Pueyo FJ, Monedero P, Busto N, Saez A. Combination of ondansetron and dexamethasone in the prophylaxis of postoperative nausea and vomiting. Br J Anaesth 1996;76:835-40.
75. Gan TJ, Ginsberg B, Grant AP, Glass PS. Double-blind, randomized comparison of ondansetron and intraoperative propofol to prevent postoperative nausea and vomiting. Anesthesiology 1996;85:1036-42.
76. Fujii Y, Toyooka H, Tanaka H. Antiemetic effects of granisetron on postoperative nausea and vomiting in patients with and without motion sickness. Can J Anaesth 1996;43:110-4.
77. Paech MJ, Pavy TJ, Evans SF. Single-dose prophylaxis for postoperative nausea and vomiting after major abdominal surgery: ondansetron versus droperidol. Anaesth Intensive Care 1995;23:548-54.
78. Fujii Y, Tanaka H, Toyooka H. Granisetron-dexamethasone combination reduces postoperative nausea and vomiting. Can J Anaesth 1995;42:387-90.
79. Fujii Y, Tanaka H, Toyooka H. Optimal anti-emetic dose of granisetron for preventing postoperative nausea and vomiting. Can J Anaesth 1994;41:794-7.
80. Sung YF, Wetchler BV, Duncalf D, Joslyn AF. A double-blind, placebo-controlled pilot study examining the effectiveness of intravenous ondansetron in the prevention of postoperative nausea and emesis. J Clin Anesth 1993;5:22-9.
81. Larijani GE, Gratz I, Afshar M, Minassian S. Treatment of postoperative nausea and vomiting with ondansetron: a randomized, double-blind comparison with placebo. Anesth Analg 1991;73:246-9.
82. Gan TJ, Meyer T, Apfel CC, et al. Consensus guidelines for managing postoperative nausea and vomiting. Anesth Analg 2003;97:62-71.
83. Habib AS, Gan TJ. The effectiveness of rescue antiemetics after failure of prophylaxis with ondansetron or droperidol: a preliminary report. J Clin Anesth 2005;17:62-5.
84. Henzi I, Walder B, Tramer MR. Dexamethasone for the prevention of postoperative nausea and vomiting: a quantitative systematic review. Anesth Analg 2000;90:186-94.
85. Habib AS, Gan TJ. Combination antiemetics: what is the evidence? Int Anesthesiol Clin 2003;41:119-44.
86. D'Angelo R, Philip B, Gan T, et al. A randomized, double-blind, close-ranging, pilot study of intravenous granisetron in the prevention of postoperative nausea and vomiting in patients abdominal hysterectomy. Eur J Anaesthesiol 2005;22:774-9.
87. Gan TJ, Coop A, Philip BK. A randomized, double-blind study of granisetron plus dexamethasone versus ondasetron plus dexamethasone to prevent postoperative nausea and vomiting in patients undergoing abdominal hysterectomy. Anesth Analg 2005;101:1323-9.