A double-blind, parallel-group, placebo-controlled, dose-ranging, multicenter study of intravenous granisetron in the treatment of postoperative nausea and vomiting in patients undergoing surgery with general anesthesia

Journal of Clinical Anesthesia

Volumn 9, Issue 8, 1997, Pages 658-663

  Taylor, Ann M ^a   Rosen, Michael ^a,b   Diemunsch, Pierre A ^a,c   Thorin, Dominique ^a,d   Houweling, Peter L ^a,e  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b UNIVERSITY HOSPITAL OF WALES   (United Kingdom)

^c UNIVERSITY HOSPITAL OF STRASBOURG   (France)

^d LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^e DEPARTMENT OF SURGERY   (Netherlands)

Author keywords

5 HT3 receptors; Granisetron; Postoperative nausea and vomiting

Indexed keywords

GRANISETRON;

ADULT; AGED; ANEMIA; ANESTHESIA COMPLICATION; ARTICLE; CLINICAL TRIAL; CONSTIPATION; CONTROLLED STUDY; DISEASE CONTROL; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG TOLERABILITY; FEMALE; GENERAL ANESTHESIA; HEADACHE; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; NAUSEA; PAIN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; VOMITING;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANESTHESIA, GENERAL; ANTIEMETICS; DOUBLE-BLIND METHOD; FEMALE; GRANISETRON; HUMANS; INJECTIONS, INTRAVENOUS; MALE; MIDDLE AGED; NAUSEA; POSTOPERATIVE COMPLICATIONS; VOMITING;

EID: 0031435374     PISSN: 09528180     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-8180(97)00190-6     Document Type: Article

References (16)

1. Watcha MF, While PF: Postoperative nausea and vomiting. Its etiology, treatment, and prevention. Anesthesiology 1992;77:162-84.
2. Lerman J: Surgical and patient factors involved in postoperative nausea and vomiting. Br J Anaesth 1992;69(7 Suppl 1):24S-32S.
3. Camu F, Lauwers MH, Verbessem D: Incidence and aetiology of postoperative nausea and vomiting. Eur J Anaesthesiol 1992;9 Suppl 6:25-31.
4. McKenzie R, Kovac A, O'Connor T, et al: Comparison of ondansetron versus placebo to prevent postoperative nausea and vomiting in women undergoing ambulatory gynecologic surgery. Anesthesiology 1993:78:21-8.
5. Wilson AJ, Diemunsch P, Lindeque BG, et al: Single-dose i.v. granisetron in the prevention of postoperative nausea and vomiting. Br J Anaesth 1996;76:515-8.
6. Bodner M, White PF: Antiemetic efficacy of ondansetron after outpatient laparoscopy. Anesth Analg 1991:73:250-4.
7. Larijani GE, Gratz I, Afshar M, Minassian S: Treatment of postoperative nausea and vomiting with ondansetron: a randomized, double-blind comparison with placebo. Anesth Analg 1991; 73:246-9.
8. Marty M, on behalf of the Granisetron Study Group: A comparison of granisetron as a single agent with conventional combination anti-emetic therapies in the treatment of cytostatic-induced emesis. Eur J Cancer 1992;28A:S12-6.
9. Kenny GN, Oates JD, Leeser J. et al: Efficacy of orally administered ondansetron in the prevention of postoperative nausea and vomiting: a dose ranging study. Br J Anaesth 1992;68:466-70.
10. 3 receptor antagonist, in the prevention of postoperative nausea and vomiting after major gynecological surgery performed under general anaesthesia. Anaesthesia 1993; 48:214-8.
11. Madej TH, Simpson KH: Comparison of the use of domperidone, droperidol and metoclopramide in the prevention of nausea and vomiting following major gynecological surgery. Br J Anaesth 1986;58:884-7.
12. Isal JP, Haigh CG, Hellstern K, et al: The clinical development of ondansetron for use in the prevention and treatment of postoperative nausea and vomiting. Eur J Anaesthesiol 1992;9 Suppl 6:33-6.
13. Kovac A, McKenzie R, O'Connor T, et al: Prophylactic intravenous ondansetron in female outpatients undergoing gynecological surgery: a multicentre dose-comparison study. Eur J Anaesthesiol 1992;9 Suppl 6:37-47.
14. Du Pen S. Scuderi P, Wetchler B, et al: Ondansetron in the treatment of postoperative nausea and vomiting in ambulatory outpatients: a dose-comparative, stratified, multicentre study. Eur J Anaesthesiol 1992;9 Suppl 6:55-62.
15. Rust M, Cohen LA: Single oral dose ondansetron in the prevention of postoperative nausea and emesis. The European and U.S. Study Groups. Anaesthesia 1994;49 Suppl:16-23.
16. Claybon L: Single dose intravenous ondansetron for the 24-hour treatment of postoperative nausea and vomiting. Anaesthesia 1994:49 Suppl:24-9.