Synthesis and in vitro antitumor activity of novel ring D analogues of the marine pyridoacridine ascididemin: Structure-activity relationship

Journal of Medicinal Chemistry

Volumn 45, Issue 17, 2002, Pages 3765-3771

  Delfourne, Evelyne ^a   Darro, Francis ^b   Portefaix, Philippe ^a   Galaup, Chantal ^a   Bayssade, Sylvie ^a   Bouteillé, Anne ^a   Le Corre, Laurent ^a   Bastide, Jean ^a   Collignon, Françoise ^b   Lesur, Brigitte ^b   Frydman, Armand ^b   Kiss, Robert ^c  

^a UNIVERSITÉ DE PERPIGNAN   (France)

^b Centre de Recherches   (France)

^c UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

2 BROMOLEPTOCLINIDONE; ACETOPHENONE DERIVATIVE; ACRIDINE DERIVATIVE; ALKALOID; ANTINEOPLASTIC AGENT; ASCIDIDEMIN; ASCIDIDEMIN DERIVATIVE; PYRIDINE DERIVATIVE; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; ASCIDIACEA; CANCER; CANCER CELL CULTURE; DRUG EFFICACY; DRUG SYNTHESIS; DRUG TOLERABILITY; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ACRIDINES; ALKALOIDS; ANIMALS; ANTINEOPLASTIC AGENTS; CELL DIVISION; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INHIBITORY CONCENTRATION 50; MICE; PHENANTHROLINES; QUINOLINES; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0037103341     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0208774     Document Type: Article

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