Synthesis and in vitro antitumor activity of phenanthrolin-7-one derivatives, analogues of the marine pyridoacridine alkaloids ascididemin and meridine: Structure-activity relationship

Journal of Medicinal Chemistry

Volumn 46, Issue 16, 2003, Pages 3536-3545

  Delfourne, Evelyne ^a   Kiss, Robert ^b   Le Corre, Laurent ^a   Dujols, Frederic ^a   Bastide, Jean ^a   Collignon, Françoise ^c   Lesur, Brigitte ^c   Frydman, Armand ^c   Darro, Francis ^c  

^a UNIVERSITÉ DE PERPIGNAN   (France)

^b UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^c Centre de Recherches   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACRIDINE DERIVATIVE; ANTINEOPLASTIC AGENT; ASCIDIDEMIN; HYDRAZONE DERIVATIVE; MERIDINE; N,N ALDEHYDE DIMETHYLHYDRAZONE; PHENANTHROLINE DERIVATIVE; QUINOLINE 5,8 DIONE; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIELS ALDER REACTION; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; MARINE ENVIRONMENT; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION; TUMOR CELL LINE;

ALKALOIDS; ANTINEOPLASTIC AGENTS; CELL DIVISION; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; HYDRAZONES; PHENANTHROLINES; QUINOLINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0042343837     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0308702     Document Type: Article

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