Immunological and pathological responses in BALB/c mice induced by genetic administration of Tc13 Tul antigen of Trypanosoma cruzi

Parasitology

Volumn 132, Issue 6, 2006, Pages 855-866

  Garcia G A ^a   Arnaiz, M R ^a   Laucella, S A ^a   Esteva, M I ^a   Ainciart, N ^a,b   Riarte, A ^a   Garavaglia, P A ^a   Fichera, L E ^a   Ruiz, A M ^a  

^a Instituto Nacional de Diagnostico e Investigacion de la Enfermedad de Chagas Dr Mario Fatala Chaben   (Argentina)

^b FUNDACIÓN INSTITUTO LELOIR   (Argentina)

Author keywords

Chagas disease; Genetic immunization; Myocarditis; Tc13; Trypanosoma cruzi

Indexed keywords

GAMMA INTERFERON; PARASITE ANTIGEN; PLASMID DNA; TC13 TUL ANTIGEN; UNCLASSIFIED DRUG;

ADOLESCENT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHAGAS DISEASE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE SEVERITY; FEMALE; HEART; HUMORAL IMMUNITY; IMMUNE RESPONSE; IMMUNIZATION; LIVER; LIVER TOXICITY; MEMORY T LYMPHOCYTE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PARASITEMIA; PATHOGENESIS; PRIORITY JOURNAL; SPLEEN; TRYPANOSOMA CRUZI; TRYPOMASTIGOTE;

ANIMALS; ANTIBODIES, PROTOZOAN; ANTIBODY FORMATION; ANTIGENS, PROTOZOAN; CERCOPITHECUS AETHIOPS; CHAGAS DISEASE; COS CELLS; FEMALE; GENE EXPRESSION; IMMUNITY, CELLULAR; INTERFERON TYPE II; MICE; MICE, INBRED BALB C; PARASITEMIA; SPLEEN; TIME FACTORS; TRYPANOSOMA CRUZI; VACCINES, DNA;

ANIMALIA; TRYPANOSOMA CRUZI;

EID: 33646725469     PISSN: 00311820     EISSN: 14698161     Source Type: Journal    
DOI: 10.1017/S0031182005009753     Document Type: Article

References (47)

1. Alvarez, P., Buscaglia, C. A. and Campetella, O. (2004). Improving protein pharmacokinetics by genetic fusion to simple amino acid sequences. The Journal of Biological Chemistry 279, 3375-3381.
2. Antunez, M. I. and Cardoni, R. L. (2000). IL-12 and IFN-gamma production, and NK cell activity, in acute and chronic experimental Trypanosoma cruzi infections. Immunology Letters. 71, 103-109.
3. Arnaiz, M. R., Fichera, L. E. and Postan, M. (2002). Cardiac myocyte hypertrophy and proliferating cell nuclear antigen expression in Wistar rats infected with Trypanosoma cruzi. Journal of Parasitology 88, 919-925.
4. Ben Younes-Chennoufi, A., Said, G., Eisen, H., Durand, A. and Hontebeyrie-Joskowicz, M. (1988). Cellular immunity to Trypanosoma cruzi is mediated by helper T cells (CD4+). Transactions of the Royal Society of Tropical Medicine and Hygiene 82, 84-89.
5. Black, C. A. (1999). Delayed type hypersensitivity, current theories with an historic perspective. Dermatology Online Journal 5, 7.
6. Boscardin, S. B., Kinoshita, S. S., Fujimura, A. E. and Rodrigues, M. M. (2003). Immunization with cDNA expressed by amastigotes of Trypanosoma cruzi elicits protective immune response against experimental infection. Infection and Immunity 71, 2744-2757.
7. Bunce, C. and Bell, E. B. (1997). CD45RC isoforms define two types of CD4 memory T cells, one of which depends on persisting antigen. The Journal of Experimental Medicine 185, 767-776.
8. Buscaglia, C. A., Alfonso, J., Campetella, O. and Frasch, A. C. (1999). Tandem amino acid repeats from Trypanosoma cruzi shed antigens increase the half-life of proteins in blood. Blood 93, 2025-2032.
9. Campetella, O., Sanchez, D., Cazzulo, J. J. and Frasch, A. C. (1992). A superfamily of Trypanosoma cruzi surface antigens. Parasitology Today 8, 378-381.
10. Carlomagno, M., Leer, G., Esteva, M. I., Hansen, D. and Segura, E. L. (1996) Role of protein deficiency on the course of Trypanosoma cruzi infection and on the degree of protection conferred by a flagellar fraction. Journal of Nutrient Immunology 4, 37-45.
11. Chu, R. S., Targoni, O. S., Krieg, A. M., Lehmann, P. V. and Harding, C. V. (1997) CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity. The Journal of Experimental Medicine 186, 1623-1631.
12. Costa, F., Pereira-Chioccola, V. L., Ribeirao, M., Schenkman, S. and Rodrigues, M. M. (1999). Trans-sialidase delivered as a naked DNA vaccine elicits an immunological response similar to a Trypanosoma cruzi infection. Brazilian Journal of Medical and Biological Research 32, 235-239.
13. Dannenberg, A. M. Jr. (1991). Delayed-type hypersensitivity and cell-mediated immunity in the pathogenesis of tuberculosis. Immunology Today 12, 228-233.
14. Frasch, A. C. (2000). Functional diversity in the trans-sialidase and mucin families in Trypanosoma cruzi. Parasitology Today 16, 282-286.
15. Frasch, A. C. (1994). Trans-sialidase, SAPA amino acid repeats and the relationship between Trypanosoma cruzi and the mammalian host. Parasitology 108 (Suppl.) S37-S44.
16. Garcia, G. A., Joensen, L. G., Bua, J., Ainciart, N., Perry, S. J. and Ruiz, A. M. (2003). Trypanosoma cruzi, molecular identification and characterization of new members of the Tc13 family. Description of the interaction between the Tc13 antigen from Tulahuen strain and the second extracellular loop of the beta(1)-adrenergic receptor. Experimental Parasitology 103, 112-119.
17. Garg, N. and Tarleton, R. L. (2002). Genetic immunization elicits antigen-specific protective immune responses and decreases disease severity in Trypanosoma cruzi infection. Infection and Immunity 70, 5547-5555.
18. Gomes, Y. M., Abath, F. G., Nakazawa, M., Minoprio, P., Vouldoukis, I. and Monjour, L. (1999). Partial protection of mice against Trypanosoma cruzi after immunizing with the TcY 72 antigenic preparation. Memorias do Instituto Oswaldo Cruz 94, 167-172.
19. Heikenwalder, M., Polymenidou, M., Junt, T., Sigurdson, C., Wagner, H., Akira, S., Zinkernagel, R. and Aguzzi, A. (2004). Lymphoid follicle destruction and immunosuppression after repeated CpG oligodeoxynucleotide administration. Nature Medicine 10, 187-192.
20. Higuchi, M. L., De Morais, C. F., Pereira Barreto, A. C., Lopes, E. A., Stolf, N., Bellotti, G. and Pileggi, F. (1987). The role of active myocarditis in the development of heart failure in chronic Chagas' disease, a study based on endomyocardial biopsies. Clinical Cardiology 10, 665-670.
21. Joensen, L., Borda, E., Kohout, T., Perry, S., Garcia, G. and Sterin-Borda, L. (2003). Trypanosoma cruzi antigen that interacts with the betal -adrenergic receptor and modifies myocardial contractile activity. Molecular and Biochemical Parasitology 127, 169-177.
22. Kahn, S. J. and Wleklinski, M. (1997). The surface glycoproteins of Trypanosoma cruzi encode a superfamily of variant T cell epitopes. The Journal of Immunology 159, 4444-4451.
23. Leon, J. S., Wang, K. and Engman, D. M. (2003). Myosin autoimmunity is not essential for cardiac inflammation in acute Chagas' disease. The Journal of Immunology 171, 4271-4277.
24. Liew, F. Y., Scott, M. T., Liu, D. S. and Croft, S. L. (1987). Suppressive substance produced by T cells from mice chronically infected with Trypanosoma cruzi. I. Preferential inhibition of the induction of delayed-type hypersensitivity. The Journal of Immunology 139, 2452-2457.
25. Martin, D. and Tarleton, R. (2004). Generation, specificity, and function of CD8+ T cells in Trypanosoma cruzi infection. Immunological Reviews 201, 304-317.
26. Millar, A. E. and Kahn, S. J. (2000). The SA85-1.1 protein of the Trypanosoma cruzi trans-sialidase superfamily is a dominant T-cell antigen. Infection and Immunity 68, 3574-3580.
27. Mucci, J., Hidalgo, A., Mocetti, E., Argibay, P. F., Leguizamon, M. S. and Campetella, O. (2002). Thymocyte depletion in Trypanosoma cruzi infection is mediated by trans-sialidase-induced apoptosis on nurse cells complex. Proceedings of the National Academy of Sciences, USA 99, 3896-3901.
28. Müller, I., Kropf, P., Etges, R. J. and Louis, J. A. (1993). Gamma interferon response in secondary Leishmania major infection: role of CD8+ T cells. Infection and Immunity 61, 3730-3738.
29. Nagata, T., Aoshi, T., Uchijima, M., Suzuki, M. and Koide, Y. (2004). Cytotoxic T-lymphocyte-, and helper T-lymphocyte-oriented DNA vaccination. DNA and Cell Biology 23, 93-106.
30. Nogueira, N. and Cohn, Z. (1977). Trypanosoma cruzi: uptake and intracellular fate in normal and activated cells. American Journal of Tropical Medicine and Hygiene 26, 194-203.
31. Norris, K. A. and Schrimpf, J. E. (1994). Biochemical analysis of the membrane and soluble forms of the complement regulatory protein of Trypanosoma cruzi. Infection and Immunity 62, 236-243.
32. Olivetti, G., Capasso, J. M., Meggs, L. G., Sonnenblick, E. H. and Anversa, P. (1991). Cellular basis of chronic ventricular remodeling after myocardial infarction in rats. Circulation Research 68, 856-869.
33. Postan, M., McDaniel, J. P. and Dvorak, J. A. (1984). Studies of Trypanosoma cruzi clones in inbred mice. II. Course of infection of C57BL/6 mice with single-cell-isolated stocks. American Journal of Tropical Medicine and Hygiene 33, 236-238.
34. Reis, M. M., Higuchi Mde, L. L., Benvenuti, A., Aiello, V. D., Gutierrez, P. S., Bellotti, G. and Pileggi, F. (1997). An in situ quantitative immunohistochemical study of cytokines and IL-2R+ in chronic human chagasic myocarditis: correlation with the presence of myocardial Trypanosoma cruzi antigens. Clinical Immunology and Immunopathology 83, 165-172.
35. Rodrigues, M. M., Ribeirao, M., Pereira-Chioccola, V., Renia, L. and Costa, F. (1999). Predominance of CD4 Th1 and CD8 Tc1 cells revealed by characterization of the cellular immune response generated by immunization with a DNA vaccine containing a Trypanosoma cruzi gene. Infection and Immunity 67, 3855-3863.
36. Schenkman, S. and Eichinger, D. (1993). Trypanosoma cruzi trans-sialidase and cell invasion. Parasitology Today 9, 218-222.
37. Silverstein, A. M. (2002). Whatever happened to cell-bound antibodies? On the overriding influence of dogma. Nature Immunology 3, 105-108.
38. Souto-Padron, T., Reyes, M. B., Leguizamon, S., Campetella, O. E., Frasch, A. C. and de Souza, W. (1989). Trypanosoma cruzi proteins which are antigenic during human infections are located in defined regions of the parasite. European Journal of Cell Biology 50, 272-278.
39. Stan, A. C., Casares, S., Brumeanu, T. D., Klinman, D. M. and Bona, C. A. (2001). CpG motifs of DNA vaccines induce the expression of chemokines and MHC class II molecules on myocytes. Eur. The Journal of Immunology 31, 301-310.
40. Sun, J. and Tarleton, R. L. (1993). Predominance of CD8+ T lymphocytes in the inflammatory lesions of mice with acute Trypanosoma cruzi infection. American Journal of Tropical Medicine and Hygiene 48, 161-169.
41. Tarleton, R. L. (2001). Parasite persistence in the aetiology of Chagas disease. International Journal for Parasitology 31, 550-554.
42. Tribulatti, M. V., Mucci, J., Van Rooijen, N., Leguizamon, M. S. and Campetella, O. (2005). The trans-sialidase from Trypanosoma cruzi induces thrombocytopenia during acute Chagas' disease by reducing the platelet sialic acid contents. Infection and Immunity 73, 201-207.
43. Whitton, J. L., Rodriguez, F., Zhang, J. and Hassett, D. E. (1999). DNA immunization, mechanistic studies. Vaccine 17, 1612-1619.
44. Wizel, B., Garg, N. and Tarleton, R. L. (1998). Vaccination with trypomastigote surface antigen 1-encoding plasmid DNA confers protection against lethal Trypanosoma cruzi infection. Infection and Immunity 66, 5073-5081.
45. Wizel, B., Nunes, M. and Tarleton, R. L. (1997). Identification of Trypanosoma cruzi trans-sialidase family members as targets of protective CD8+ TC1 responses. The Journal of Immunology 159, 6120-6130.
46. World Health Organization (1999). Chagas Disease: Tropical Disease Research Progress 1997-1998. WHO Technical Report Series, No 14. WHO, Geneva.
47. Zhang, L. and Tarleton, R. L. (1996). Characterization of cytokine production in murine Trypanosoma cruzi infection by in situ immunocytochemistry, lack of association between susceptibility and type 2 cytokine production. European Journal of Immunology 26, 102-109.