The Sa85-1.1 protein of the Trypanosoma cruzi trans-sialidase superfamily is a dominant T-cell antigen

Infection and Immunity

Volumn 68, Issue 6, 2000, Pages 3574-3580

  Millar, Amanda E ^a   Kahn, Stuart J ^a,b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; SIALIDASE; T LYMPHOCYTE ANTIGEN;

ADOPTIVE TRANSFER; ANIMAL CELL; ANTIBODY RESPONSE; ARTICLE; CELL PROLIFERATION; CHAGAS DISEASE; ENZYME SPECIFICITY; IMMUNIZATION; INFECTION CONTROL; LYMPHOCYTE COUNT; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; SPLEEN CELL; TRYPANOSOMA CRUZI; TRYPOMASTIGOTE;

ACUTE DISEASE; AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, PROTOZOAN; CD4-POSITIVE T-LYMPHOCYTES; CHAGAS DISEASE; FEMALE; IMMUNODOMINANT EPITOPES; INTERFERON TYPE II; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; NEURAMINIDASE; PEPTIDES; PROTOZOAN PROTEINS; SPLEEN; STAINING AND LABELING; TRYPANOSOMA CRUZI;

EID: 0034118186     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.68.6.3574-3580.2000     Document Type: Article

References (25)

1. +) T lymphocytes. Infect. Immun. 57:2246-2248.
2. Campetella, O., D. Sanchez, J. J. Cazzulo, and A. C. C. Frasch. 1992. A superfamily of Trypanosoma cruzi surface antigens. Parasitol. Today 8:378-381.
3. Constant, S. L., and K. Bottomly. 1997. Induction of Th1 and Th2 CD4+ T cell responses: the alternative approaches. Annu. Rev. Immunol. 15:297-322.
4. Cross, G. A., and G. B. Takle. 1993. The surface trans-sialidase family of Trypanosoma cruzi. Annu. Rev. Microbiol. 47:385-411.
5. Dos Santos, R. R., M. A. Rossi, J. L. Laus, J. S. Silva, W. Savino, and J. Mengel. 1992. Anti-CD4 abrogates rejection and reestablishes long-term tolerance to syngeneic newborn hearts grafted in mice chronically infected with Trypanosoma cruzi. J. Exp. Med. 175:29-39.
6. Evavold, B. D., J. Sloan-Lancaster, and P. M. Allen. 1993. Tickling the TCR: selective T-cell functions stimulated by altered peptide ligands. Immunol. Today 14:602-609.
7. Hontebeyrie, J.-M., G. Said, G. Milon, G. Marchal, and H. Eisen. 1987. L3T4+ T cells able to mediate parasite-specific delayed-type hypersensitivity play a role in the pathology of experimental Chagas' disease. Eur. J. Immunol. 17:1027-1033.
8. Kahn, S., T. G. Colbert, J. C. Wallace, N. A. Hoagland, and H. Eisen. 1991. The major 85-kDa surface antigen of the mammalian-stage forms of Trypanosoma cruzi is a family of sialidases. Proc. Natl. Acad. Sci. USA 88:4481-4485.
9. Kahn, S., M. Kahn, W. C. Van Voorhis, A. Goshorn, A. Strand, N. Hoagland, H. Eisen, and S. Pennathur. 1993. SA85-1 proteins of Trypanosoma cruzi lack sialidase activity. Mol. Biochem. Parasitol. 60:149-152.
10. Kahn, S., W. C. Van Voorhis, and H. Eisen. 1990. The major 85-kD surface antigen of the mammalian form of Trypanosoma cruzi is encoded by a large heterogeneous family of simultaneously expressed genes. J. Exp. Med. 172: 589-597.
11. Kahn, S. J., D. Nguyen, J. Norsen, M. Wleklinski, T. Granston, and M. Kahn. 1999. Trypanosoma cruzi: monoclonal antibodies to the surface glycoprotein superfamily differentiate subsets of the 85-kDa surface glycoproteins and confirm simultaneous expression of variant 85-kDa surface glycoproteins. Exp. Parasitol. 92:48-56.
12. Kahn, S. J., and M. Wleklinski. 1997. The surface glycoproteins of Trypanosoma cruzi encode a superfamily of variant T cell epitopes. J. Immunol. 159:4444-4451.
13. Kahn, S. J., M. Wleklinski, R. A. B. Ezekowitz, D. Coder, A. Aruffo, and A. Farr. 1996. The major surface glycoproteins of Trypanosoma cruzi amastigotes are ligands of the human serum mannose binding protein. Infect. Immun. 64:2649-2656.
14. Locksley, R. M., S. L. Reiner, F. Hatam, D. R. Littman, and N. Killeen. 1993. Helper T cells without CD4: control of leishmaniasis in CD4-deficient mice. Science 261:1448-1451.
15. Millar, A. E., M. Wleklinski-Lee, and S. J. Kahn. 1999. The surface protein superfamily of Trypanosoma cruzi stimulates a polarized Th1 response that becomes anergic. J. Immunol. 162:6092-6099.
16. Minoprio, P. M., H. Eisen, L. Forni, L.-M. R. D'Imperio, M. Joskowicz, and A. Coutinho. 1986. Polyclonal lymphocyte responses to murine Trypanosoma cruzi infection. I. Quantitation of both T- and B-cell responses. Scand. J. Immunol. 24:661-668.
17. Nabors, G. S., and R. L. Tarleton. 1991. Differential control of IFN-gamma and IL-2 production during Trypanosoma cruzi infection. J. Immunol. 146: 3591-3598.
18. Plata, F., F. Garcia-Pons, and H. Eisen. 1984. Antigenic polymorphism of Trypanosoma cruzi: clonal analysis of trypomastigote surface antigens. Eur. J. Immunol. 14:392-399.
19. Rottenberg, M. E., M. Bakhiet, T. Olsson, K. Kristensson, T. Mak, H. Wigzell, and A. Orn. 1993. Differential susceptibilities of mice genomically deleted of CD4 and CD8 to infections with Trypanosoma cruzi or Trypanosoma brucei. Infect. Immun. 61:5129-5133.
20. Rottenberg, M. E., D. A. Rodriguez, and A. Orn. 1992. Control of Trypanosoma cruzi infection in mice deprived of T-cell help. Scand. J. Immunol. 36:261-268.
21. Russo, M., N. Starobinas, P. Minoprio, A. Coutinho, and J.-M. Hontebeyrie. 1988. Parasitic load increases and myocardial inflammation decreases in Trypanosoma cruzi-infected mice after inactivation of helper T cells. Ann. Inst. Pasteur Immunol. 139:225-236.
22. Tarleton, R. L., M. J. Grusby, M. Postan, and L. H. Glimcher. 1996. Trypanosoma cruzi infection in MHC-deficient mice: further evidence for the role of both class I- and class II-restricted T cells in immune resistance and disease. Int. Immunol. 8:13-22.
23. Van Voorhis, W. C., L. Barrett, R. Koelling, and A. G. Farr. 1993. FL-160 proteins of Trypanosoma cruzi are expressed from a multigene family and contain two distinct epitopes that mimic nervous tissues. J. Exp. Med. 178: 681-694.
24. Van Voorhis, W. C., and H. Eisen. 1989. Fl-160. A surface antigen of Trypanosoma cruzi that mimics mammalian nervous tissue. J. Exp. Med. 169:641-652.
25. World Health Organization. 1991. Control of Chagas disease 811. World Health Organization, Geneva, Switzerland.