Trans-sialidase delivered as a naked DNA vaccine elicits an immunological response similar to a Trypanosoma cruzi infection

Brazilian Journal of Medical and Biological Research

Volumn 32, Issue 2, 1999, Pages 235-239

  Costa, F ^a   Pereira Chioccola, V L ^a,b   Ribeirao, M ^a   Schenkman, S ^a   Rodrigues, M M ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^b INSTITUTO DANTE PAZZANESE DE CARDIOLOGIA   (Brazil)

Author keywords

Chagas' disease; DNA vaccination; Trans sialidase

Indexed keywords

ANTIBODY; DNA VACCINE; GLYCOCONJUGATE; PLASMID VECTOR; RECOMBINANT PROTEIN; SIALIC ACID; SIALIDASE;

AMINO TERMINAL SEQUENCE; ANIMAL MODEL; ANTIBODY PRODUCTION; CHAGAS DISEASE; CONFERENCE PAPER; ENZYME ACTIVITY; GENE SEQUENCE; GENE TARGETING; IMMUNIZATION; INTERFERON PRODUCTION; MOUSE; NONHUMAN; PATHOGENICITY; PATHOPHYSIOLOGY; PROTEIN DOMAIN; T LYMPHOCYTE ACTIVATION; TRYPANOSOMA CRUZI; VACCINATION;

ANIMALIA; PROTOZOA; TRYPANOSOMA; TRYPANOSOMA CRUZI;

EID: 0033053597     PISSN: 0100879X     EISSN: 1414431X     Source Type: Journal    
DOI: 10.1590/S0100-879X1999000200013     Document Type: Conference Paper

References (25)

1. de Andrade AL, Zicker F, de Oliveira RM, Almeida Silva S, Luquetti A, Travassos LR, Almeida IC, de Andrade SS, de Andrade JG & Martelli CM (1996). Randomised trial of efficacy of benznidazole in treatment of early Trypanosoma cruzi infection. Lancet, 348: 1407-1413.
2. Viotti R, Vigliano C, Armenti H & Segura E (1994). Treatment of chronic Chagas' disease with benznidazole: clinical and serologic evolution of patients with long-term follow up. American Heart Journal, 127: 151-162.
3. Cazzulo JJ & Frasch ACC (1992). SAPA/ trans-sialidase and cruzipain: two antigens from Trypanosoma cruzi contain immunodominant but enzymatically inactive domains. FASEB Journal, 6: 3259-3264.
4. Cross GAM & Tackle GB (1993). The surface trans-sialidase family of Trypanosoma cruzi. Annual Review of Microbiology, 46: 383-411.
5. Schenkman S, Eichinger D, Pereira MEA & Nussenzweig V (1994). Structural and functional properties of Trypanosoma trans-sialidase. Annual Review of Microbiology, 48: 499-523.
6. Ouassi MA, Cornette J & Capron A (1986). Identification and isolation of Trypanosoma cruzi trypomastigote cell surface protein with properties expected of a fibronectin receptor. Molecular and Biochemical Parasitology, 19: 201-211.
7. Lima MF & Villalta F (1989). Trypanosoma cruzi trypomastigote clones differentially express a parasite cell adhesion molecule. Molecular and Biochemical Parasitology, 33: 159-170.
8. Giordano R, Chammas R, Veiga SS, Colli W & Alves MJ (1994). An acidic component of the heterogeneous Tc-85 protein family from the surface of Trypanosoma cruzi is a laminin binding glycoprotein. Molecular and Biochemical Parasitology, 65: 85-94.
9. Ming M, Chuenkova M, Ortega-Barria M & Pereira MEA (1993). Mediation of Trypanosoma cruzi invasion by sialic acid on the host cell and trans-sialidase on the trypanosome. Molecular and Biochemical Parasitology, 59: 234-252.
10. Kahn S, Wleklinski M, Aruffo A, Farr A, Coder D & Khan M (1995). Trypanosoma cruzi amastigote adhesion to macrophages is facilitated by the mannose receptor. Journal of Experimental Medicine, 182: 1243-1258.
11. Pereira MEA, Zhang K, Gong Y, Herrera EM & Ming M (1996). Invasive phenotype of Trypanosoma cruzi is restricted to a population expressing trans-sialidase. Infection and Immunity, 64: 3884-3892.
12. Schenkman S, Man-Shiow J, Hart GW & Nussenzweig V (1991). A novel cell surface trans-sialidase of Trypanosoma cruzi generates a stage-specific epitope required for invasion of mammalian cells. Cell, 65: 1117-1125.
13. Schenkman S, De Carvalho LP & Nussenzweig V (1992). Trypanosoma cruzi trans-sialidase and neuraminidase activities can be mediated by the same enzymes. Journal of Experimental Medicine, 175: 567-575.
14. Schenkman RPF, Vandekerckhove F & Schenkman S (1993). Mammalian cell sialic acid enhances Trypanosoma cruzi invasion. Infection and Immunity, 61: 898-902.
15. Pereira MEA, Meija JS, Ortega-Barria E, Matzilevich D & Prioli RP (1991). Trypanosoma cruzi neuraminidase contains sequences similar to bacterial neuraminidases, YWTD repeats of the low density receptor, and type III module of fibronectin. Journal of Experimental Medicine, 174: 179-191.
16. Parodi A, Pollevick GD, Mautner M, Buschiazzo A, Sanchez DO & Frasch ACC (1992). Identification of the gene(s) encoding the trans-sialidase of Trypanosoma cruzi. EMBO Journal, 11: 1705-1710.
17. Uemura H, Schenkman S, Nussenzweig V & Eichinger D (1992). Only some members of a gene family in Trypanosoma cruzi encode proteins that express both trans-sialidase and neuraminidase activities. EMBO Journal, 11: 3837-3844.
18. Ribeirāo M, Pereira-Chioccola VL, Eichinger D, Rodrigues MM & Schenkman S (1997). Temperature differences for trans-glycosylation and hydrolysis reaction reveal an acceptor binding site in the catalytic mechanism of Trypanosoma cruzi trans-sialidase. Glycobiology, 7: 1237-1246.
19. Pereira-Chioccola VL, Schenkman S & Kloetzel JK (1994). Sera from chronic chagasic patients and rodents infected with Trypanosoma cruzi inhibit transsialidase by recognizing its amino-terminal and catalytic domain. Infection and Immunity, 62: 2973-2978.
20. Leguizamon MS, Campetella O, Russomando G, Almiron M, Gonzalez-Cappa SM & Frasch AC (1994). Antibodies inhibiting Trypanosoma cruzi transsialidase activity in sera from human infections. Journal of Infectious Disease, 170: 1570-1574.
21. Chuenkova M & Pereira MEA (1995). Trypanosoma cruzi trans-sialidase: Enhancement of virulence in a murine model of Chagas' disease. Journal of Experimental Medicine, 181: 1693-1703.
22. Franchin G, Pereira-Chioccola VL, Schenkman S & Rodrigues MM (1997). Passive transfer of a monoclonal antibody specific for a sialic acid-dependent epitope on the surface of Trypanosoma cruzi trypomastigotes reduces infection in mice. Infection and Immunity, 65: 2548-2554.
23. Pereira-Chioccola VL, Costa F, Ribeirāo M, Soares IS, Arena F, Schenkman S & Rodrigues MM (1998). Comparison of antibody and protective immune responses against Trypanosoma cruzi infection elicited by immunization with a parasite antigen delivered as naked DNA or recombinant proteir. Parasite Immunology, 20: (in press).
24. Costa F, Franchin G, Pereira-Chioccola VL, Ribeirāo M, Schenkman S & Rodrigues MM (1998). Immunization with a plasmid DNA containing the gene of transsialidase reduces Trypanosoma cruzi infection in mice. Vaccine, 16: 768-774.
25. Hölscher C, Kölner G, Müller U, Mossman H. Schaub GA & Brombacher F (1998). Defective nitric oxide effector function leads to extreme susceptibility of Trypanosoma cruzi-infected mice deficient in gamma interferon receptor or inducible nitric oxide synthase. Infection and Immunity, 66: 1208-1215.