Trypanosoma cruzi antigen that interacts with the β1-adrenergic receptor and modifies myocardial contractile activity

Molecular and Biochemical Parasitology

Volumn 127, Issue 2, 2003, Pages 169-177

  Joensen, Lilian ^a   Borda, Enri ^a   Kohout, Trudy ^b   Perry, Stephen ^b   García, Gabriela ^a   Sterin Borda, Leonor ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Chagas' disease; Cyclic AMP; Ligand binding assay; Myocardial contractility; Tc13 Tul antigen

Indexed keywords

ATENOLOL; BETA 1 ADRENERGIC RECEPTOR; MEMBRANE ANTIGEN; PARASITE ANTIGEN;

ANIMAL CELL; ARTICLE; BINDING SITE; CHAGAS DISEASE; CHO CELL; HEART MUSCLE CONTRACTILITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; RECEPTOR BINDING; TRYPANOSOMA CRUZI;

TRYPANOSOMA; TRYPANOSOMA CRUZI;

EID: 0037417217     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-6851(03)00003-3     Document Type: Article

References (37)

1. Burns J.M., Shreffler W.G., Rosman D.E., Sleath P.R., March C.J., Reed S. Identification and synthesis of a major conserved antigenic epitope of Trypanosoma cruzi. Proc. Natl. Acad. Sci. U.S.A. 89:1992;1239-1243.
2. Frasch A.C.C. Functional diversity in the trans-sialidase and mucin families in Trypanosoma cruzi. Parasitol. Today. 16:2000;282-286.
3. Avila H., Goncalves A.M., Nehme S.N., Morel C.M., Simpson L. Schizodeme analysis of Trypanosoma cruzi stocks from South and Central America by analysis of PCR-amplified minicircle variable region sequences. Mol. Biochem. Parasitol. 42:1990;175-188.
4. Miles M., Souza A., Povoa M., Shaw J., Lainson R., Toye P. Isozymic heterogeneity of Trypanosoma cruzi in the first autochthonous patients with Chagas' disease in Amazonian Brazil. Nature (London). 272:1978;819-821.
5. Wrightsman R., Krassner S., Watson J. Genetic control of responses to Trypanosoma cruzi in mice: multiple genes influencing parasitemia and survival. Infect. Immunol. 36:1982;637-644.
6. Trischmann T.M., Bloom B.R. Genetics of murine resistance to Trypanosoma cruzi. Infect. Immunol. 35:1982;546-551.
7. Davies J.M. Molecular mimicry: can epitope mimicry induce autoimmune disease? Immunol. Cell Biol. 75:1997;113-126.
8. Eisen H., Kahn S. Mimicry in Trypanosoma cruzi: fantasy and reality. Curr. Opin. Immunol. 3:1991;201-203.
9. Borda E., Pascual J., Cossio P., Vega M., Arana R., Sterin-Borda L. A circulating IgG in Chagas' disease which binds to beta-adrenoceptor of myocardium and modulates its activity. Clin. Exp. Immunol. 54:1984;679-686.
10. Cremashi G.A., Zwirner N.W., Gorelik G., Malchiodi E.L., Chiaramonte M.G., Fossati C.A. Modulation of cardiac physiology by anti-Trypanosoma cruzi monoclonal antibody after interaction with myocardium. FASEB J. 9:1995;1482-1488.
11. Sterin-Borda L., Gorelik G., Genaro A.M., Goin J.C., Borda E.S. Human chagasic IgG interacting with lymphocyte neurotransmitter receptors triggers intracellular signal transduction. FASEB J. 4:1990;1661-1667.
12. Gorelik G., Genaro A.M., Sterin-Borda L., Gonzalez Cappa S., Borda E.S. Antibodies bind and activate beta-adrenergic and cholinergic lymphocyte receptors in Chagas' disease. Clin. Immunol. Immunopathol. 55:1990;221-226.
13. Kierszenbaum F., Sztein M.B. Mechanisms underlying immunosuppression induced by Trypanosoma cruzi. Parasitol. Today. 6:1990;261-264.
14. Cross G.A.M., Takle G.B. The surface trans-sialidase family of Trypanosoma cruzi. Ann. Rev. Microbiol. 47:1993;385-411.
15. Borda E.S., Sterin-Borda L., Pascual J., Gorelik G., Felix J., van Kreuter B.F.et al. Trypanosoma cruzi attachment to lymphocyte muscarinic cholinergic and beta-adrenergic receptors modulates intracellular signal transduction. Mol. Biochem. Parasitol. 47:1991;91-100.
16. von Kreuter B.F., Santos-Buch C.A. Modulation of T. cruzi adhesion to host muscle cell membrane by ligands of muscarinic cholinergic and beta-adrenergic receptors. Mol. Biochem. Parasitol. 36:1989;41-50.
17. Magdesian M.H., Giordanos R., Ulrich H., Juliano M.A., Juliano L., Schumacher R.I.et al. Infection by Trypanosoma cruzi. Identification of a parasite ligand and its host cell receptor. J. Biol. Chem. 276:2001;19382.
18. Souto-Padrón T., Reyes M.B., Leguizamon S., Campetella O., Frasch A.C.C., de Souza W. Trypanosoma cruzi proteins which are antigenic during human infections are located in defined regions of the parasite. Eur. J. Cell Biol. 50:1989;272-278.
19. Campetella O., Sanchez D., Cazzulo J.J., Frasch A.C.C. A superfamily of Trypanosoma cruzi surface antigens. Parasitol. Today. 8:1992;378-381.
20. Buscaglia C.A., Alfonso J., Campetella O., Frasch A.C.C. Tandem amino acid repeats from Trypanosoma cruzi shed antigens increase the half-life of proteins in blood. Blood. 93:1999;2025-2032.
21. Krettli A., Weisz Carrington P., Neussenzweig R. Membrane bound antibodies to bloodstream Trypanosoma cruzi in mice: strain differences in susceptibility to complement-mediated lysis. Clin. Exp. Immunol. 37:1979;416-423.
22. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the folin phenol reagent. J. Biol. Chem. 193:1951;265-275.
23. 2-adrenergic receptor are involved in distinct pathways of receptor desensitization. J. Biol. Chem. 264:1989;12657-12665.
24. 125I ]-CYP) Life Sci. 29:1981;2189-2198.
25. Bice D.E., Zeledon R.J. Comparison of infectivity of strains of Trypanosoma cruzi (Chagas, 1909). J. Parasitol. 56:1970;663-670.
26. Hall B.S., Tam W., Sen R., Pereira M.E. Cell-specific activation of nuclear factor-kappa B by the parasite Trypanosoma cruzi promotes resistance to intracellular infection. Mol. Biol. Cell. 11:2000;153-160.
27. Chuenkova M.V., Pereira M.A. A trypanosomal protein synergizes with the cytokines ciliary neutrophic factor and leukemia inhibitory factor to prevent apoptosis of neuronal cells. Mol. Biol. Cell. 11:2000;1487-1498.
28. Hoffman BB, Lefkowitz RJ. Goodman and Gilman's pharmacological basis of therapeutics. In: Hardman JG, Gilman AG, Limbird LE, editors. New York: McGraw Hill; 1996. p. 199-248.
29. Goin J.C., Perez Leiros C., Borda E., Sterin-Borda L. Interaction of human chagasic IgG with the second extracellular loop of the human heart muscarinic acetylcholine receptor: functional and pathological implications. FASEB J. 10:1997;77-83.
30. 2 muscarinic acetylcholine receptors by autoantibodies from patients with Chagas' disease. J. Biol. Chem. 272:1997;12898-12993.
31. Sterin-Borda L., Gorelik G., Postan M., Gonzalez Cappa S., Borda E. Alterations in cardiac beta-adrenergic receptors in chagasic mice and their association with circulating beta-adrenoceptor-related autoantibodies. Cardiovas. Res. 41:1999;116-125.
32. Goin J.C., Sterin-Borda L., Bilder C., Monastra Varrica L., Iantorno G., Castro Rios M.et al. Functional implications of circulating muscarinic cholinergic receptor autoantibodies in chagasic patients with achalasia. Gastroenterology. 117:1999;798-805.
33. van Voorhis W.C., Eisem H. A surface antigen of T. cruzi that mimics mammalian nervous tissue. J. Exp. Med. 169:1989;641-646.
34. Cossio P.M., Diez C., Szarfman A., Kreutzer E., Candiolo B., Arana R.M. Chagasic cardiopathy: demonstration of a serum gamma globulin factor which reacts with endocardium and vascular structures. Circulation. 49:1974;13-21.
35. Tibbetts R.S., Mc Cornick E.C., Rowland S.D., Enzman D.M. Cardiac antigen-specific autoantibody production in associated with cardiomyopathy in T. cruzi-infected mice. J. Immunol. 152:1994;1493-1498.
36. Kierszenbaum F. Chagas disease and autoimmunity hypothesis. Clin. Microbiol. Rev. 12:1999;210-223.
37. Schijman A.G., Levin M.J. Nucleotide sequence of a cDNA encoding a Trypanosoma cruzi acidic ribosomal PO protein: a novel C-terminal domain in T. cruzi ribosomal P proteins. Nucleic Acids Res. 20:1992;2894-2897.