Molecular modeling of mono- and bis-quaternary ammonium salts as ligands at the α4β2* nicotinic acetylcholine receptor subtype using nonlinear techniques

AAPS Journal

Volumn 7, Issue 3, 2005, Pages

  Ayers, Joshua T ^a,b   Clauset, Aaron ^c   Schmitt, Jeffrey D ^d   Dwoskin, Linda P ^a   Crooks, Peter A ^a  

^a University of Kentucky   (United States)

^b ASTRAZENECA   (United Kingdom)

^c University of New Mexico   (United States)

^d TARGACEPT INC   (United States)

Author keywords

Genetic functional approximation; Neuronal nicotinic acetylcholine receptor; Self organizing map

Indexed keywords

NICOTINIC RECEPTOR; QUATERNARY AMMONIUM DERIVATIVE; RECEPTOR SUBTYPE; LIGAND; NICOTINIC RECEPTOR ALPHA4BETA2;

ALGORITHM; ANIMAL TISSUE; ARTICLE; COMPUTER PROGRAM; CONTROLLED STUDY; HYDROPHOBICITY; IN VITRO STUDY; MATHEMATICAL COMPUTING; MOLECULAR MODEL; NONHUMAN; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RAT; RECEPTOR AFFINITY; REGRESSION ANALYSIS; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; CHEMICAL STRUCTURE; CHEMISTRY; NONLINEAR SYSTEM;

LIGANDS; MODELS, MOLECULAR; NONLINEAR DYNAMICS; QUATERNARY AMMONIUM COMPOUNDS; RECEPTORS, NICOTINIC;

EID: 33646660250     PISSN: 15221059     EISSN: 15221059     Source Type: Journal    
DOI: 10.1208/aapsj070368     Document Type: Article

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