A2A adenosine receptor: A novel therapeutic target in renal disease

American Journal of Physiology - Renal Physiology

Volumn 282, Issue 1 51-1, 2002, Pages

  Okusa, Mark D ^a  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

Acute renal failure; ATL 146e; Inflammation; Ischemia reperfusion; ZM 243185

Indexed keywords

4 [3 [6 AMINO 9 (5 ETHYLCARBAMOYL 3,4 DIHYDROXYTETRAHYDRO 2 FURYL) 9H PURIN 2 YL] 2 PROPYNYL]CYCLOHEXANECARBOXYLIC ACID METHYL ESTER; ADENOSINE A2A RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG; ZM 243185;

DRUG MECHANISM; DRUG RECEPTOR BINDING; INFLAMMATION; KIDNEY DISEASE; KIDNEY ISCHEMIA; MOLECULAR BIOLOGY; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN FAMILY; REPERFUSION INJURY; REVIEW;

EID: 0036080003     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.2002.282.1.f10     Document Type: Review

References (88)

1. Role for intrarenal adenosine in the renal hemodynamic response to contrast media
2. Radiocontrast medium-induced declines in renal function: A role for oxygen free radicals
3. Oxidant mechanisms in toxic acute renal failure
4. Endothelial cells inhibit receptor-mediated superoxide anion production by human polymorphonuclear leukocytes via soluble inhibitor
5. Differential regulatory effects of adenosine on cytokine release by activated human monocytes
6. Adenosine inhibits cytokine release and expresion of adhesion molecules by activated human endothelial cells
7. 2 receptors to inhibit neutrophil adhesion and injury to isolated cardiac myocytes
8. A basis for distinguishing two types of purinergic receptor
9. Polymorphoneutrophils in acute renal failure: New insights
10. α-Melanocyte-stimulating hormone inhibits renal injury in the absence of neutrophils
11. Adenosine, an endogenous anti-inflammatory agent
12. --generation, respectively
13. Adenosine: A physiological regulator of superoxide anion generation by human neutrophils
14. Adenosine: An endogenous inhibitor of neutrophil-mediated injury to endothelial cells
15. 2 receptors
16. 2 receptor on human neutrophils
17. ICAM-1 anti-sense oliogodesoxynucleotides prevent reperfusion injury and enhance immediate graft function in renal transplantation
18. The physiological activity of adenine compounds with special reference to their action upon the mammalian heart
19. Endogenous adenosine curtails lipopolysaccharide-stimulated tumour necrosis factor synthesis
20. Adenosine antagonist theophylline prevents the reduction of glomerular filtration rate after contrast media application
21. Inhibition of neutrophil adhesion by adenosine and an adenosine kinase inhibitor
22. 2A-adenosine receptors in human peripheral blood cells
23. Leukocyte-endothelial cell adhesion induced by ischemia and reperfusion
24. Inhibition of neutrophil superoxide production by adenosine released from vascular endothelial cells
25. Antisense oligonucleotides for ICAM-1 attenuate reperfusion injury and renal failure in the rat
26. 2a receptor-dependent and independent mechanisms
27. Adenosine receptor agonists differentially regulate IL-10, TNF-α, and nitric oxide production in RAW 264.7 macrophages and in endotoxemic mice
28. G(olf) and Gs in rat basal ganglia: Possible involvement of G(olf) in the coupling of dopamine D 1 receptor with adenylyl cyclase
29. 3H]CGS 21680, a selective A2 adenosine receptor agonist directly labels A2 receptors in rat brain
30. 2 receptor activation attenuates reperfusion injury by inhibiting neutrophil accumulation, superoxide generation and coronary endothelial adherence
31. Antibody to intercellular adhesion molecule 1 protects the kidney against ischemic injury
32. Intercellular adhesion molecule-1-deficient mice are protected against ischemic renal injury
33. Amelioration of cisplatin-induced acute renal failure with 8-cyclopentyl- 1,3-dipropylxanthine
34. Localization of adenosine-receptor subtype mRNA in rat outer medullary descending vasa recta by RT-PCR
35. The role of neutrophils in acute renal failure
36. 2 receptor
37. Complete nucleotide sequence of a putative G protein coupled receptor: RDC7
38. Complete nucleotide sequence of a putative G protein coupled receptor: RDC8
39. 1 adenosine receptor
40. 3 receptors: Pharmacological properties, species differences and receptor functions
41. Molecular approach to adenosine receptors: Receptor mediated mechanisms of tissue protection
42. Molecular biology and pharmacology of recombinant adenosine receptors
43. 2a receptors inhibits IL-12 production by human monocytes
44. Paracrine regulation of the renal microcirculation
45. 2a receptors on renal microvascular reactivity
46. 2A-AR) agonists reduce MHC antigen expression in activated human leukocytes
47. 2A-adenosine receptor-mediated inhibition of renal injury and neutrophil adhesion
48. 2A-adenosine receptor activation and PDE 4 inhibition
49. 2A-adenosine receptor activation during reperfusion reduces ischemia-reperfusion injury in rat kidney
50. Adenosine receptor subtypes: Characterization and therapeutic regulation
51. 2A receptors and neuroprotection
52. 2A receptors
53. Effect of neutrophil depletion on ischemic renal injury in the rat
54. 2a adenosine receptor: Delineation of multiple processes
55. Stimulation of A2A-adenosine receptors phosphorylation by protein kinase C activation: Evidence for regulation of multiple protein kinase C isoforms
56. 2b receptor from human brain
57. Antibodies to ICAM-1 protect kidneys in severe ischemic reperfusion injury
58. Leukocytes, cell adhesion molecules and ischemic acute renal failure
59. 2 receptors on rat Kupffer cells
60. 2 receptor occupancy regulates stimulated neutrophil function via activation of a serine/threonine protein phosphatase
61. 2A receptor agonists
62. Inhibition by adenosine of reactive oxygen metabolite production by human polymorphonuclear leukocytes
63. 2A receptors in the rat central nervous system
64. 2A activation reduces lung reperfusion injury following transplantation
65. 3 adenosine receptor
66. 3 adenosine receptor
67. 2 adenosine receptors
68. Methylxanthine bronchodilators potentiate multiple human neutrophil functions
69. The effects of adenosine agonists on human neutrophil function
70. 3 receptors expressed in Chinese hamster ovary cells all mediate the phosphorylation of extracellular-regulated kinase 1/2
71. 2A-adenosine receptor in primary human endothelial cells
72. Adenosine modulates vasomotor tone in outer medullary descending vasa recta of the rat
73. Protection from ischemia-reperfusion induced severe acute renal failure by blocking E-selectin
74. Immunolocalisation of adenosine A(1) receptors in the rat kidney
75. Treatment of acute renal failure
76. The specific type IV phosphodiesterase inhibitor rolipram combined with adenosine reduces tumor necrosis factor-α (TNF-α)-primed neutrophil oxidative activity
77. 2A adenosine receptors in inflammation
78. 2A receptor agonists
79. The cytokine-adhesion molecule cascade in ischemia/reperfusion injury of the rat kidney
80. Prevention of radiographic-contrast-agent-induced reductions in renal function by acetylcysteine
81. Acute renal failure
82. Adenosine receptor occupancy suppresses chemoattractant-induced phospholipase D activity by diminishing membrane recruitment of small GTPases
83. 1 adenosine receptor cDNA
84. Suppression of mesangial proliferative glomerulonephritis development in rats by inhibitors of cAMP phosphodiesterase isozymes types III and IV
85. Adenosine and cerebral ischemia: Therapeutic future or death of a brave concept
86. Adenosine receptor gene expression in rat kidney
87. 2 receptors adenosine inhibits the upregulation of Mac-1 (Cd11β/CD18) expression on FMLP-stimulated neutrophils
88. ATP-channel activation