A classical QSAR study on some platelet aggregation inhibitors

Mini-Reviews in Medicinal Chemistry

Volumn 6, Issue 4, 2006, Pages 467-482

  Verma, Rajeshwar P ^a  

^a POMONA COLLEGE   (United States)

Author keywords

Adenosine diphosphate (ADP); Arachidonic acid (AA); CMR; Collagen (Col); Hydrophobicity; Platelet aggregation inhibitors; QSAR; Thrombin (Thr)

Indexed keywords

1,4 NAPHTHOQUINONE DERIVATIVE; 15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; ADENOSINE DIPHOSPHATE; ALCOHOL DERIVATIVE; AMIDE; AMIDINOHYDRAZONE; ANTITHROMBOCYTIC AGENT; ARACHIDONIC ACID; CAFFEIC ACID DERIVATIVE; CATECHOL DERIVATIVE; COLLAGEN; ISOQUINOLINE DERIVATIVE; MALONALDEHYDE; PHENOL DERIVATIVE; PHENOXYACETALDEHYDE GUANYLHYDRAZONE DERIVATIVE; PHOSPHONIC ACID DERIVATIVE; PYRROLOBENZYLISOQUINOLINE DERIVATIVE; TETRALIN DERIVATIVE; THROMBIN; THROMBOCYTE ACTIVATING FACTOR; UNCLASSIFIED DRUG;

CALCULATION; CORRELATION ANALYSIS; DATA ANALYSIS; DRUG ACTIVITY; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; HUMAN; HYDROPHOBICITY; MOLECULAR BIOLOGY; NONHUMAN; PHYSICAL CHEMISTRY; QUANTITATIVE STRUCTURE ACTIVITY RELATION; REVIEW; STATISTICAL ANALYSIS; THROMBOCYTE AGGREGATION;

HUMANS; PLATELET AGGREGATION INHIBITORS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33646571491     PISSN: 13895575     EISSN: None     Source Type: Journal    
DOI: 10.2174/138955706776361484     Document Type: Review

References (27)

1. Weston, C.; Rao, U. Int. J. Clin. Practice 2003, 57, 898.
2. Clutton, P.; Folts, J. D.; Freedman, J. E. Pharmacol. Res. 2001, 44, 255.
3. Ault, K. A.; Cannon, C. P.; Mitchell, J.; McCahan, J.; Tracy, R. P.; Novotny W. F.; Reimann, J. D.; Braunwald, E. J. Am. Coll. Cardiol. 1999, 33, 634.
4. Helft, G.; Osende, J. I.; Worthley, S. G.; Zaman, A. G.; Rodriguez, O. J.; Lev, E. I.; Farkouh, M. E.; Fuster, V.; Badimon, J. J.; Chesebro, J. H. Arterioscler. Thromb. Vasc. Biol. 2000, 20, 2316.
5. Zhang, W.; Yao, J.; Pham, V.; Whitney, T.; Froese, D.; Friesen, A. D.; Stang, L.; Xu, C.; Shuaib, A.; Diakur, J. M.; Haque, W. Bioorg. Med. Chem. Lett. 2004, 14, 4747.
6. C-QSAR Program, BioByte Corp., 201W. 4th st., Suit 204, Claremont, CA 91711, USA. www.biobyte.com
7. Hansch, C.; Leo, A. In Exploring QSAR: Fundamentals and Applications in Chemistry and Biology; American Chemical Society; Washington, DC, 1995.
8. Kitagawa, S.; Ito, Y.; Oda, Y.; Kametani, F. Biochem. Biophys. Acta 1989, 1011, 52.
9. Kitagawa, S.; Fujisawa, H.; Baba, S.; Kametani, F. Chem. Pharm. Bull. 1991, 39, 1062.
10. Hung, C.-C.; Tsai, W.-J.; Kuo, L.-M. Y.; Kuo, Y.-H. Bioorg. Med. Chem. 2005, 13, 1791.
11. Kitagawa, S.; Shinohara, T.; Kametani, F. J. Membrane Biol. 1984, 79, 97.
12. Lien, J.-C.; Huang, L.-J., Teng, C.-M., Wang, J.-P.; Kuo, S.-C. Chem. Pharm. Bull. 2002, 50, 672.
13. Cimetiere, B.; Dubuffet, T.; Muller, O.; Descombes, J.-J.; Simonet, S.; Laubie M.; Verbeuren, T. J.; Lavielle, G. Bioorg. Med. Chem. Lett. 1998, 8, 1375.
14. Berge, G.; Darmanaden, R.; Artis-Noel, A.-M.; Fulcrand, P.; Castle, J.; Orzalesi, H. Eur. J. Med. Chem., 1983, 18, 45.
15. Kuo, R.-Y.; Wu, C.-C.; Chang, F.-R.; Yeh, J.-L., Chen, I.-J.; Wu, Y.-C. Bioorg. Med. Chem. Lett. 2003, 13, 821.
16. Ingall, A. H.; Dixon, J.; Bailey, A.; Coombs, M. E.; Cox, D.; McInally, J. I.; Hunt, S. F.; Kindon, N. D.; Teobald, B. J.; Willis, P. A.; Humphries, R. G.; Leff, P.; Clegg, J. A.; Smith, J. A.; Tomlinson, W. J. Med. Chem. 1999, 42, 213.
17. Verma, R. P. Bioorg. Med. Chem. 2005, 13, 1059.
18. Hansch, C.; Verma, R. P.; Kurup, A.; Mekapati, S. B. Bioorg. Med. Chem. Lett. 2005, 15, 2149.
19. Verma, R. P.; Hansch, C. Bioorg. Med. Chem. 2005, 13, 4597.
20. Monod, J.; Wyman, J.; Changeux, J. P. J. Mol. Biol., 1965, 12, 88.
21. Koshland, D. E., Jr.; Hamadani, K. J. Biol. Chem. 2002, 277, 46841.
22. Bender, W.; Staudt, M.; Trankle, C.; Mohr, K. Life Sci. 2000, 66, 1675.
23. Hansch, C.; Garg, R.; Kurup, A. Bioorg. Med. Chem. 2001, 9, 283.
24. Hansch, C.; Hoekman, D.; Leo, A.; Weininger, D.; Selassie, C. D. Chem. Rev. 2002, 102, 783.
25. Hansch, C.; Garg, R.; Kurup, A.; Mekapati, S. B. Bioorg. Med. Chem. 2003, 11, 2075.
26. Verma, R. P. Lett. Drug Des. Discov. 2005, 2, 205.
27. Mekapati, S. B.; Kurup, A.; Verma, R. P.; Hansch, C. Bioorg. Med. Chem. 2005, 13, 3737.