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Volumn 40, Issue 28, 2001, Pages 8227-8236
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Mechanistic basis for suicide inactivation of porphobilinogen synthase by 4,7-Dioxosebacic acid, an inhibitor that shows dramatic species selectivity
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a
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Author keywords
[No Author keywords available]
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Indexed keywords
SUICIDE INACTIVATION;
BIOSYNTHESIS;
CATALYSIS;
CHLOROPHYLL;
ESCHERICHIA COLI;
MONOMERS;
SUBSTRATES;
ENZYMES;
4,7 DIOXOSEBACIC ACID;
AMINOLEVULINIC ACID;
ENZYME INHIBITOR;
PORPHOBILINOGEN SYNTHASE;
SCHIFF BASE;
UNCLASSIFIED DRUG;
ARTICLE;
BINDING SITE;
BRADYRHIZOBIUM;
CRYSTAL STRUCTURE;
ENZYME ACTIVE SITE;
ENZYME ASSAY;
ENZYME BINDING;
ENZYME INACTIVATION;
ENZYME KINETICS;
ENZYME MECHANISM;
ENZYME STRUCTURE;
ESCHERICHIA COLI;
HYDROGEN BOND;
PEA;
PRIORITY JOURNAL;
PSEUDOMONAS AERUGINOSA;
SPECIES DIFFERENCE;
AMINO ACID SEQUENCE;
BINDING SITES;
CATIONS, DIVALENT;
CRYSTALLIZATION;
CRYSTALLOGRAPHY, X-RAY;
DECANOIC ACIDS;
ENZYME ACTIVATION;
ENZYME INHIBITORS;
ESCHERICHIA COLI;
HUMANS;
KINETICS;
MAGNESIUM;
MOLECULAR SEQUENCE DATA;
MUTAGENESIS, SITE-DIRECTED;
PORPHOBILINOGEN SYNTHASE;
SCHIFF BASES;
SPECIES SPECIFICITY;
SUBSTRATE SPECIFICITY;
ZINC;
BRADYRHIZOBIUM;
BRADYRHIZOBIUM JAPONICUM;
ESCHERICHIA COLI;
PISUM SATIVUM;
PSEUDOMONAS;
PSEUDOMONAS AERUGINOSA;
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EID: 0035902505
PISSN: 00062960
EISSN: None
Source Type: Journal
DOI: 10.1021/bi010656k Document Type: Article |
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Times cited : (41)
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References (36)
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