Rat hepatocyte aquaporin-8 water channels are down-regulated in extrahepatic cholestasis

Hepatology

Volumn 37, Issue 5, 2003, Pages 1026-1033

  Carreras, Flavia I ^a   Gradilone, Sergio A ^a   Mazzone, Amelia ^b   García, Fabiana ^a   Huang, Bing Q ^c   Ochoa, J Elena ^a   Tietz, Pamela S ^c   LaRusso, Nicholas F ^c   Calamita, Giuseppe ^b   Marinelli, Raúl A ^a  

^a UNIVERSIDAD NACIONAL DE ROSARIO   (Argentina)

^b UNIVERSITY OF BARI   (Italy)

^c MAYO CLINIC COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AQUAPORIN; AQUAPORIN 8; CYCLIC AMP; MESSENGER RNA; UNCLASSIFIED DRUG; WATER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE DUCT LIGATION; BILE SECRETION; CELL ASSAY; CELL LEVEL; CELL MEMBRANE; CELL VACUOLE; CELLULAR DISTRIBUTION; DOWN REGULATION; EXTRAHEPATIC BILE DUCT OBSTRUCTION; GENE EXPRESSION; IMMUNOBLOTTING; IMMUNOGOLD ELECTRON MICROSCOPY; IMMUNOHISTOCHEMISTRY; LIVER CELL; LIVER SLICE; MALE; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN TRANSPORT; RAT; RNA ANALYSIS; TIME;

EID: 0037698852     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1053/jhep.2003.50170     Document Type: Article

References (35)

1. Masyuk AI, Marinelli RA, LaRusso NF. Water transport by epithelia of the digestive tract. Gastroenterology 2002;122:545-562.
2. Kozono D, Yasui M, King LS, Agre P. Aquaporin water channels: atomic structure molecular dynamics meet clinical medicine. J Clin Invest 2002;109:1395-1399.
3. Tsukaguchi H, Shayakul C, Berger UV, Mackenzie B, Devidas S, Guggino WB, van Hoek AN, et al. Molecular characterization of a broad selectivity neutral solute channel. J Biol Chem 1998;273:24737-24743.
4. Elkjaer M-L, Vajda Z, Nejsum LN, Kwon T-H, Jensen UB, AmiryMoghaddam M, Frokiaer J, et al. Immunolocalization of AQP9 in liver, epididymis, testis, spleen, and brain. Biochem Biophys Res Commun 2000;276:1118-1128.
5. Garcia F, Kierbel A, Larocca MC, Gradilone SA, Splinter P, LaRusso NF, Marinelli RA. The water channel aquaporin-8 is mainly intracellular in rat hepatocytes and its plasma membrane insertion is stimulated by cyclic AMP. J Biol Chem 2001;276:12147-12152.
6. Calamita G, Mazzone A, Bizzoca A, Cavalier A, Cassano G, Thomas D, Svelto M. Expression and immunolocalization of the aquaporin-8 water channel in rat gastrointestinal tract. Eur J Cell Biol 2001;80:711-719.
7. Nicchia GP, Frigeri A, Nico B, Ribatti D, Svelto M. Tissue distribution and membrane localization of aquaporin-9 water channel: evidence for sex-linked differences in liver. J Histochem Cytochem 2001;49:1547-1556.
8. Elkjaer ML, Nejsum LN, Gresz V, Kwon TH, Jensen UB, Frokiaer J, Nielsen S. Immunolocalization of aquaporin-8 in rat kidney, gastrointestinal tract, testis, and airways. Am J Physiol Renal Physiol 2001;281: F1047-F1057.
9. Tani T, Koyama Y, Nihei K, Hatakeyama S, Ohshiro K, Yoshida Y, Yaoita E, et al. Immunolocalization of aquaporin-8 in rat digestive organs and testis. Arch Histol Cytol 2001;64:159-168.
10. Huebert RC, Splinter PL, García F, Marinelli RA, LaRusso NF. Expression and localization of aquaporin water channels in rat hepatocytes. Evidence for a role in canalicular bile secretion. J Biol Chem 2002;277:22710-22717.
11. Lee J, Boyer JL. Molecular alterations in heparocyte transport mechanisms in acquired cholestatic liver disorders. Semin Liver Dis 2000;20:373-384.
12. Melgert BN, Olinga P, Van Der Laan JM, Weert B, Cho J, Schuppan D, Groothuis GM, et al. Targeting dexamethasone to Kupffer cells: effects on liver inflammation and fibrosis in rats. HEPATOLOGY 2001;34:719-728.
13. Lowry OH, Rosebrough NJ, Farr AL, Randall RJJ. Protein measured with the Folin phenol reagent. J Biol Chem 1951;193:265-275.
14. Burchell A, Hume R, Burchell B. A new microtechnique for the analysis of the human hepatic microsomal glucose-6-phosphatase system. Clin Chim Acta 1988;173:183-191.
15. Meier PJ, Sztul ES, Reuben A, Boyer JL. Structural and functional polarity of canalicular and basolateral plasma membrane vesicles isolated in high yield from rat liver. J Cell Biol 1984;98:991-1000.
16. Volentine GD, Tuma DJ, Sorrell MF. Subcellular location of secretory proteins retained in the liver during the ethanol-induced inhibition of hepatic protein secretion in the rat. Gastroenterology 1986;90:158-165.
17. Liou W, Geuze HJ, Slot JW. Improving structural integrity of cryosections for immunogold labeling. Histochem Cell Biol 1996;106:41-58.
18. Trauner M, Arrese M, Soroka CJ, Ananthanarayanan M, Koeppel TA, Schlosser SF, Suchy FJ, et al. The rat canalicular conjugate export pump (Mrp2) is down-regulated in intrahepatic and obstructive cholestasis. Gastroenterology 1997;113:255-264.
19. Gartung C, Ananthanarayanan M, Rahman MA, Schuele S, Nundy S, Soroka CJ, Stolz A, et al. Down-regulation of expression and function of the rat liver Na+/bile acid cotransporter in extrahepatic cholestasis. Gastroenterology 1996;110:199-209.
20. 2+-ATPase in cholestatic rat liver. Histochem J 1998;30:909-916.
21. Bouscarel B, Matsuzaki Y, Le M, Gettys TW, Fromm H. Changes in G protein expression account for impaired modulation of hepatic cAMP formation after BDL. Am J Physiol 1998;274:G1151-G1159.
22. Fricker G, Landmann L, Meier PJ. Extrahepatic obstructive cholestasis reverses the bile salt secretory polarity of rat hepatocytes. J Clin Invest 1989;84:876-885.
23. Stieger B, Meier PJ, Landmann L. Effect of obstructive cholestasis on membrane traffic and domain-specific expression of plasma membrane proteins in rat liver parenchymal cells. HEPATOLOGY 1994;20:201-212.
24. Calamita G, Spalluto C, Mazzone A, Rocchi M, Svelto M. Cloning, structural organization and chromosomal localization of the mouse aquaporin-8 water channel gene. Cytogenet Cell Genet 1999;85:237-241.
25. Rippin SJ, Hagenbuch B, Meier PJ, Stieger B. Cholestatic expression pattern of sinusoidal and canalicular organic anion transport systems in primary cultured rat hepatocytes. HEPATOLOGY 2001;33:776-782.
26. Paulusma CC, Kothe MJ, Bakker CT, Bosma PJ, van Bokhoven I, van Marie J, Bolder U, et al. Zonal down-regulation and redistribution of the multidrug resistance protein 2 during bile duct ligation in rat liver. HEPATOLOGY 2000;31:684-693.
27. Meier PJ, Steiger B. Molecular mechanisms in bile formation. News Physiol Sci 2000;15:89-93.
28. Lee JM, Trauner M, Soroka CJ, Stieger B, Meier PJ, Boyer JL. Expression of the bile salt export pump is maintained after chronic cholestasis in the rat. Gastroenterology 2000;118:163-172.
29. Marinelli RA, Pham L, Agre P, LaRusso NF. Secretin promotes osmotic water transport in rat cholangiocytes by increasing aquaporin-1 water channels in plasma membrane. Evidence for secretin-induced vesicular translocation of aquaporin-1. J Biol Chem 1997;272:12984-12988.
30. Marinelli RA, Tietz PS, Pham LD, Rueckert L, Agre P, LaRusso NF. Secretin induces the apical insertion of aquaporin-1 water channels in rat cholangiocytes. Am J Physiol 1999;276:G280-G286.
31. Cova E, Gong A, Marinelli RA, LaRusso NF. Water movement across rat bile duct units is transcellular and channel-mediated. HEPATOLOGY 2001;34:456-463.
32. Gong AY, Masyuk AI, Splinter PL, Huebert RC, Tietz PS, LaRusso NF. Channel-mediated water movement across enclosed or perfused mouse intrahepatic bile duct units. Am J Physiol 2002;283:C338-C346.
33. Mennone A, Verkman AS, Boyer JL. Unimpaired osmotic water permeability and fluid secretion in bile duct epithelia of AQP1 null mice. Am J Physiol 2002;283:G739-G746.
34. Splinter PL, Masyuk AI, LaRusso NF. Specific inhibition of AQP1 water channels in isolated rat intrahepatic bile duct units by small interfering RNAs. J Biol Chem 2003;278:6268-6274.
35. Accatino L, Contreras A, Berdichevsky E, Quintana C. The effect of complete biliary obstruction on bile secretion. Studies on the mechanisms of postcholestatic choleresis in the rat. J Lab Clin Med 1981;97:525-534.