Mice expressing human mutant presenilin-1 exhibit decreased activation of NF-κB p50 in hippocampal neurons after injury

Molecular Brain Research

Volumn 110, Issue 1, 2003, Pages 152-157

  Kassed, C A ^a   Butler, T L ^a   Navidomskis, M T ^a   Gordon, M N ^a,b   Morgan, D ^a,b   Pennypacker, K R ^a  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

^b UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

Fluoro Jade; Hippocampus; mutPS 1 mice; Neurodegeneration; Neuroprotection; Neurotoxicity; NF B; P50; Presenilin 1 gene mutations; Resistance to injury; Signal transduction; Transcription factors; Trimethyltin

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MUTANT PROTEIN; PRESENILIN 1; PROTEIN P50; TRIMETHYLTIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MORTALITY; MOUSE; MUTATION; NERVE CELL LESION; NERVE DEGENERATION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

ALZHEIMER DISEASE; ANIMALS; HIPPOCAMPUS; MEMBRANE PROTEINS; MICE; MICE, TRANSGENIC; NERVE DEGENERATION; NEURONS; NF-KAPPA B; NF-KAPPA B P50 SUBUNIT; PRESENILIN-1;

MUS MUSCULUS;

EID: 0037474096     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(02)00658-7     Document Type: Article

References (32)

1. Baeuerle P.A., Baltimore D. A 65-kDa subunit of active NF-kappaB is required for inhibition of NF-kappaB by I kappaB. Genes Dev. 3:1989;1689-1698.
2. Barrow P., Empson R., Gladwell S., Anderson C., Killick R., Yu X., Jeffreys J., Duff K. Functional phenotype in transgenic mice expressing mutant human presenilin-1. Neurobiol. Dis. 7:2000;119-126.
3. Cechetto D.F. Role of nuclear factor kappa B in neuropathological mechanisms. Prog. Brain Res. 132:2001;391-404.
4. Duff K., Eckman C., Zehr C., Yu X., Prada C.-M., Perez-Tur J., Hutton M., Buee L., Harigaya Y., Morgan D., Gordon M., Holcomb L., Refolo L., Zenk B., Hardy J., Younkin S. Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1. Nature. 383:1996;710-713.
5. Grabellus F., Levkau B., Sokoll A., Welp H., Schmid C., Deng M.C., Takeda A., Breithardt G., Baba H.A. Reversible activation of nuclear factor-kappaB in human end-stage heart failure after left ventricular mechanical support. Cardiovasc. Res. 53:2002;124-130.
6. Guo Q., Robinson N., Mattson M.P. Secreted beta-amyloid precursor protein counteracts the proapoptotic action of mutant presenilin-1 by activation of NF-kappaB and stabilization of calcium homeostasis. J. Biol. Chem. 273:1998;12341-12351.
7. Guo Z., Lee J., Lane M., Mattson M. Iodoacetate protects hippocampal neurons against excitotoxic and oxidative injury: involvement of heat-shock proteins and Bcl-2. J. Neurochem. 79:2001;361-370.
8. Hardy J. The Alzheimer family of diseases: many etiologies, one pathogenesis? Proc. Natl. Acad. Sci. USA. 94:1997;2095-2097.
9. Henkel T., Zabel U., van Zee K., Muller J., Fanning E., Baeuerle P. Intramolecular masking of the nuclear location signal and dimerization domain in the precursor for the p50 NF-κB subunit. Cell. 68:1992;1121-1133.
10. Imafuku I., Masaki T., Waragai M., Takeuchi S., Kawabata M., Hirai S., Ohno S., Nee L., Lippa C., Kanazawa I., Imagawa M., Okazawa H. Presenilin-1 suppresses the function of c-Jun homodimers via interaction with QM/Jif-1. J. Cell Biol. 147:1999;121-134.
11. Kaltschmidt C., Kaltschmidt B., Baeuerle P.A. Brain synapses contain inducible forms of the transcription factor NF-kappa B. Mech. Dev. 43:1993;135-147.
12. Kaltschmidt C., Kaltschmidt B., Neumann H., Wekerle H., Baeuerle P.A. Constitutive NF-kappa B activity in neurons. Mol. Cell. Biol. 14:1994;3981-3992.
13. Kassed C., Willing A., Garbuzova-Davis S., Sanberg P., Pennypacker K. Lack of NF-κB p50 exacerbates degeneration of hippocampal neurons after chemical exposure and impairs learning. Exp. Neurol. 176:2002;277-288.
14. Kim J., Chang T., Lee J., Huh S., Yeon S., Yang W., Joe C., Mook-Jung I., Tanzi R., Kim T., Choi E. Negative regulation of the SAPK/JNK signaling pathway by presenilin-1. J. Cell. Biol. 153:2001;457-463.
15. Makarov S.S. NF-kappaB as a therapeutic target in chronic inflammation: recent advances. Mol. Med. Today. 6:2000;441-448.
16. Masliah E., Westland C., Rockenstein E., Abraham C., Mallory M., Veinberg I., Sheldon E., Mucke L. Amyloid precursor proteins protect neurons of transgenic mice against acute and chronic excitotoxic injuries in vivo. Neuroscience. 78:1997;135-146.
17. Mattson M., Culmsee C., Yu Z., Camandola S. Roles of nuclear factor kappa B in neuronal survival and plasticity. J. Neurochem. 74:2000;443-456.
18. Murphy M., Uljon S., Fraser P., Fauq A., Lookingbill H., Findlay K., Smith T., Lewis P., McLendon D., Wang R., Golde T. Presenilin-1 regulates pharmacologically distinct γ-secretase activities. J. Biol. Chem. 275:2000;26277-262284.
19. Nath A., Anderson C., Jones M., Maragos W., Booze R., Mactutus C., Bell J., Hauser K.F., Mattson M. Neurotoxicity and dysfunction of dopaminergic systems associated with AIDS dementia. J. Psychopharmacol. 14:2000;222-227.
20. Pennypacker K., Kassed C., Eidizadeh S., Saporta S., Sanberg P., Willing A. NF-κB p50 is increased in neurons surviving hippocampal injury. Exp. Neurol. 172:2001;307-319.
21. Perez-Otaño I., McMillian M., Chen J., Bing G., Hong J., Pennypacker K. Induction of NF-κB-like transcription factors in brain areas susceptible to kainate toxicity. Glia. 16:1996;306-315.
22. Schmued L.C., Hopkins K.J. Fluoro-Jade: novel fluorochromes for detecting toxicant-induced neuronal degeneration. Toxicol. Pathol. 28:2000;91-99.
23. Schmued L., Albertson C., Slikker W. Fluoro-Jade: a novel fluorochrome for the sensitive and reliable histochemical localization of neuronal degeneration. Brain Res. 751:1997;37-46.
24. Schütze S., Potthoff K., Machleidt T., Benkovic D., Wiegmann K., Krönke M. TNF activates NF-κB by phosphatidylcholine-specific phospholipase C-induced 'acidic' sphingomyelin breakdown. Cell. 71:1992;765-766.
25. Selkoe D.J., Wolfe M.S. In search of gamma-secretase: presenilin at the cutting edge. Proc. Natl. Acad. Sci. USA. 97:2000;5690-5692.
26. Shizuka-Ikeda M., Matsubara E., Ikeda M., Kanai M., Tomidokoro Y., Ikeda Y., Watanabe M., Kawarabayashi T., Harigaya Y., Okamoto K., Maruyama K., Castano E.M., St George-Hyslop P., Shoji M. Generation of amyloid beta protein from a presenilin-1 and betaAPP complex. Biochem. Biophys. Res. Commun. 292:2002;571-578.
27. Smith-Swintosky V., Pettigrew L., Craddock S., Culwell A., Rydel R., Mattson M. Secreted forms of beta-amyloid precursor protein protect against ischemic brain injury. J. Neurochem. 63:1994;781-784.
28. Ueberla K., Lu Y., Chung E., Haseltine W. The NFkB p65 promoter. J. AIDS. 6:1993;227-230.
29. Wolozin B., Iwasaki K., Vito P., Ganjei J., Lacana E., Sunderland T., Zhao B., Kusiak J., Wasco W., D'Adamio L. Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation. Science. 274:1996;1710-1713.
30. R. Wover, T. Purves, P. Fernyhough, G. Glazner, NF-κB activation is a component in signaling pathway required for maintenance of adult sensory neurons, in: I. Verma, D. Baltimore, (Eds.), Keystone Symposia: NF-κB: Bench to Bedside, Keystone, CO, 2002, pp. 62.
31. Yu Z., Zhou D., Bruce-Keller A., Kindy M., Mattson M. Lack of p50 subunit of nuclear factor-kB increases the vulnerability of hippocampal neurons to excitotoxic injury. J. Neurosci. 19:1999;8856-8865.
32. Zabel U., Henkel T., Siva M., Baeuerle P. Nuclear uptake control of NF-κB by MAD-3, an IkB protein present in the nucleus. EMBO J. 12:1993;201-211.