Glycosyltransferases and their products: Cryptococcal variations on fungal themes

FEMS Yeast Research

Volumn 6, Issue 4, 2006, Pages 499-512

  Klutts, James Stacey ^a   Yoneda, Aki ^a   Reilly, Morgann C ^a   Bose, Indrani ^a   Doering, Tamara L ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cryptococcus; Fungi; Glycan; Glycosylation; Glycosyltransferase; Polysaccharide

Indexed keywords

1,3 BETA GLUCAN SYNTHASE; ALPHA 1,3 GLUCAN SYNTHASE; BETA 1,6 GLUCAN SYNTHASE; CARBOHYDRATE DERIVATIVE; CHITIN SYNTHASE; GLYCOCONJUGATE; GLYCOLIPID; GLYCOPROTEIN; GLYCOSYLTRANSFERASE; LIPID; MANNOSYLTRANSFERASE; MANNOSYLTRANSFERASE CMT1P; MONOSACCHARIDE; PROTEIN; TOXIC SUBSTANCE; UNCLASSIFIED DRUG; XYLOSYLTRANSFERASE CXT1P;

CELL WALL; CRYPTOCOCCUS NEOFORMANS; ENZYME MECHANISM; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; MAMMAL; NONHUMAN; NUCLEOTIDE SEQUENCE; PROKARYOTE; PROTEIN GLYCOSYLATION; SHORT SURVEY; SURVIVAL;

CELL WALL; CRYPTOCOCCUS; FUNGAL PROTEINS; GLYCOLIPIDS; GLYCOPROTEINS; GLYCOSYLATION; GLYCOSYLTRANSFERASES; HUMANS; MODELS, MOLECULAR;

FILOBASIDIELLA NEOFORMANS; MAMMALIA; PROKARYOTA;

EID: 33646554156     PISSN: 15671356     EISSN: 15671364     Source Type: Journal    
DOI: 10.1111/j.1567-1364.2006.00054.x     Document Type: Short Survey

References (85)

1. Ballou L Ballou C 1995 Schizosaccharomyces pombe mutants that are defective in glycoprotein galactosylation Proc Natl Acad Sci USA 92 2790 2794
2. Ballou CE Ballou L Ball G 1994 Schizosaccharomyces pombe glycosylation mutant with altered cell surface properties Proc Natl Acad Sci USA 91 9327 9331
3. Banks IR Specht CA Donlin MJ Gerik KJ Levitz SM Lodge JK 2005 A chitin synthase and its regulator protein are critical for chitosan production and growth of the fungal pathogen Cryptococcus neoformans Eukaryotic Cell 4 1902 1912
4. Bar-Peled M Griffith CL Doering TL 2001 Functional cloning and characterization of a UDP-glucuronic acid decarboxylase the pathogenic fungus Cryptococcus neoformans elucidates UDP-xylose synthesis Proc Natl Acad Sci USA 98 12003 12008
5. Beauvais A Maubon D Park S Morelle W Tanguy M Huerre M Perlin DS Latge JP 2005 Two alpha(1-3) glucan synthases with different functions in Aspergillus fumigatus Appl Environ Microbiol 71 1531 1538
6. 2+ concentrations at 37 degrees C, is required for mannosylation of inositolphosphorylceramide Mol Gen Genet 255 570 579
7. Bose I Reese AJ Ory JJ Janbon G Doering TL 2003 A yeast under cover the capsule of Cryptococcus neoformans Eukaryot Cell 2 655 663
8. Breton C Snajdrova L Jeanneau C Koca J Imberty A 2006 Structures and mechanisms of glycosyltransferases superfamily Glycobiology 16 29R 37R
9. Burda P Aebi M 1999 The dolichol pathway of N-linked glycosylation Biochim Biophys Acta 1426 239 257
10. Campbell JA Davies GJ Bulone V Henrissat B 1997 A classification of nucleotide-diphospho-sugar glycosyltransferases based on amino acid sequence similarities Biochem J 326 929 939
11. Carotti C Ragni E Palomares O Fontaine T Tedeschi G Rodriguez R Latge JP Vai M Popolo L 2004 Characterization of recombinant forms of the yeast Gas1 protein and identification of residues essential for glucanosyltransferase activity and folding Eur J Biochem 271 3635 3645
12. Chang YC Kwon-Chung KJ 1994 Complementation of a capsule-deficient mutation of Cryptococcus neoformans restores its virulence Mol Cell Biol 14 4912 4919
13. Chang YC Kwon-Chung KJ 1998 Isolation of the third capsule-associated gene, CAP60, required for virulence in Cryptococcus neoformans Infect Immun 66 2230 2236
14. Chang YC Kwon-Chung KJ 1999 Isolation, characterization, and localization of a capsule-associated gene, CAP10, of Cryptococcus neoformans J Bacteriol 181 5636 5643
15. Chang YC Penoyer LA Kwon-Chung KJ 1996 The second capsule gene of Cryptococcus neoformans, CAP64, is essential for virulence Infect Immun 64 1977 1983
16. Cherniak R Valafar H Morris LC Valafar F 1998 Cryptococcus neoformans chemotyping by quantitative analysis of 1H nuclear magnetic resonance spectra of glucuronoxylomannans with a computer-simulated artificial neural network Clin Diagn Lab Immunol 5 146 159
17. Coutinho PM Deleury E Davies GJ Henrissat B 2003 An evolving hierarchical family classification for glycosyltransferases J Mol Biol 328 307 317
18. Cutler JE 2001 N-glycosylation of yeast, with emphasis on Candida albicans Med Mycol 39 75 86
19. Dean N 1999 Asparagine-linked glycosylation in the yeast Golgi Biochim Biophys Acta 1426 309 322
20. Dickson RC Nagiec EE Wells GB Nagiec MM Lester RL 1997 Synthesis of mannose-(inositol-P)2-ceramide, the major sphingolipid in Saccharomyces cerevisiae, requires the IPT1 (YDR072c) gene J Biol Chem 272 29620 29625
21. Dijkgraaf GJ Abe M Ohya Y Bussey H 2002 Mutations in Fks1p affect the cell wall content of beta-1,3- and beta-1,6-glucan in Saccharomyces cerevisiae Yeast 19 671 690
22. Djordjevic JT Del Poeta M Sorrell TC Turner KM Wright LC 2005 Secretion of cryptococcal phospholipase B1 (PLB1) is regulated by a glycosylphosphatidylinositol (GPI) anchor Biochem J 389 803 812
23. Douglas CM 2001 Fungal beta(1,3)- d -glucan synthesis Med Mycol 39 55 66
24. Duran A Nombela C 2004 Fungal cell wall biogenesis building a dynamic interface with the environment Microbiology 150 3099 3103
25. Eisenhaber B Maurer-Stroh S Novatchkova M Schneider G Eisenhaber F 2003 Enzymes and auxiliary factors for GPI lipid anchor biosynthesis and post-translational transfer to proteins Bioessays 25 367 385
26. Fankhauser C Homans SW Thomas-Oates JE McConville MJ Desponds C Conzelmann A Ferguson MA 1993 Structures of glycosylphosphatidylinositol membrane anchors from Saccharomyces cerevisiae J Biol Chem 268 26365 26374
27. Fontaine T Magnin T Melhert A Lamont D Latge JP Ferguson MA 2003 Structures of the glycosylphosphatidylinositol membrane anchors from Aspergillus fumigatus membrane proteins Glycobiology 13 169 177
28. Franzot SP Doering TL 1999 Inositol acylation of glycosylphosphatidylinositols in the pathogenic fungus Cryptococcus neoformans and the model yeast Saccharomyces cerevisiae Biochem J 340 25 32
29. Frieman MB McCaffery JM Cormack BP 2002 Modular domain structure in the Candida glabrata adhesin Epa1p, a beta1,6 glucan-cross-linked cell wall protein Mol Microbiol 46 479 492
30. Garcia-Rivera J Chang YC Kwon-Chung KJ Casadevall A 2004 Cryptococcus neoformans CAP59 (or Cap59p) is involved in the extracellular trafficking of capsular glucuronoxylomannan Eukaryot Cell 3 385 392
31. Gemmill TR Trimble RB 1999a Overview of N- and O-linked oligosaccharide structures found in various yeast species Biochim Biophys Acta 1426 227 237
32. Gemmill TR Trimble RB 1999b Schizosaccharomyces pombe produces novel Gal0-2Man1-3 O-linked oligosaccharides Glycobiology 9 507 515
33. Griffith CL Klutts JS Zhang L Levery SB Doering TL 2004 UDP-glucose dehydrogenase plays multiple roles in the biology of the pathogenic fungus Cryptococcus neoformans J Biol Chem 279 51669 51676
34. De Groot PW Ram AF Klis FM 2005 Features and functions of covalently linked proteins in fungal cell walls Fungal Genet Biol 42 657 675
35. Heidler SA Radding JA 2000 Inositol phosphoryl transferases from human pathogenic fungi Biochim Biophys Acta 1500 147 152
36. Hochstenbach F Klis FM van den Ende H van Donselaar E Peters PJ Klausner RD 1998 Identification of a putative alpha-glucan synthase essential for cell wall construction and morphogenesis in fission yeast Proc Natl Acad Sci USA 95 9161 9166
37. Hu Y Walker S 2002 Remarkable structural similarities between diverse glycosyltransferases Chem Biol 9 1287 1296
38. Huang C Nong SH Mansour MK Specht CA Levitz SM 2002 Purification and characterization of a second immunoreactive mannoprotein from Cryptococcus neoformans that stimulates T-cell responses Infect Immun 70 5485 5493
39. Idnurm A Reedy JL Nussbaum JC Heitman J 2004 Cryptococcus neoformans virulence gene discovery through insertional mutagenesis Eukaryot Cell 3 420 429
40. Jacobson ES Ayers DJ Harrell AC Nicholas CC 1982 Genetic and phenotypic characterization of capsule mutants of Cryptococcus neoformans J Bacteriol 150 1292 1296
41. Janbon G Himmelreich U Moyrand F Improvisi L Dromer F 2001 Cas1p is a membrane protein necessary for the O-acetylation of the Cryptococcus neoformans capsular polysaccharide Mol Microbiol 42 453 467
42. Kang JY Hong Y Ashida H Shishioh N Murakami Y Morita YS Maeda Y Kinoshita T 2005 PIG-V involved in transferring the second mannose in glycosylphosphatidylinositol J Biol Chem 280 9489 9497
43. Katayama S Hirata D Arellano M Perez P Toda T 1999 Fission yeast alpha-glucan synthase Mok1 requires the actin cytoskeleton to localize the sites of growth and plays an essential role in cell morphogenesis downstream of protein kinase C function J Cell Biol 144 1173 1186
44. Kikuchi N Kwon YD Gotoh M Narimatsu H 2003 Comparison of glycosyltransferase families using the profile hidden Markov model Biochem Biophys Res Commun 310 574 579
45. Klis FM Mol P Hellingwerf K Brul S 2002 Dynamics of cell wall structure in Saccharomyces cerevisiae FEMS Microbiol Rev 26 239 256
46. Klutts JS Levery SB Doering TL 2005 A beta-1,2 xylosyltransferase from Cryptococcus neoformans. 6th International Conference on Cryptococcus and Cryptococcosis. Boston, MA.
47. Kraus PR Fox DS Cox GM Heitman J 2003 The Cryptococcus neoformans MAP kinase Mpk1 regulates cell integrity in response to antifungal drugs and loss of calcineurin function Mol Microbiol 48 1377 1387
48. Leipelt M Warnecke D Zahringer U Ott C Muller F Hube B Heinz E 2001 Glucosylceramide synthases, a gene family responsible for the biosynthesis of glucosphingolipids in animals, plants, and fungi J Biol Chem 276 33621 33629
49. + adduct ions Rapid Commun Mass Spectrom 14 551 563
50. Levitz SM Nong S Mansour MK Huang C Specht CA 2001 Molecular characterization of a mannoprotein with homology to chitin deacetylases that stimulates T cell responses to Cryptococcus neoformans Proc Natl Acad Sci USA 98 10422 10427
51. Li RK Rinaldi MG 1999 In vitro antifungal activity of nikkomycin Z in combination with fluconazole or itraconazole Antimicrob Agents Chemother 43 1401 1405
52. Liu J Mushegian A 2003 Three monophyletic superfamilies account for the majority of the known glycosyltransferases Protein Sci 12 1418 1431
53. Loftus BJ Fung E Roncaglia P et al 2005 The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans Science 307 1321 1324
54. Luberto C Toffaletti DL Wills EA Tucker SC Casadevall A Perfect JR Hannun YA Del Poeta M 2001 Roles for inositol-phosphoryl ceramide synthase 1 (IPC1) in pathogenesis of C. neoformans Genes Dev 15 201 212
55. Maligie MA Selitrennikoff CP 2005 Cryptococcus neoformans resistance to echinocandins (1,3)beta-glucan synthase activity is sensitive to echinocandins Antimicrob Agents Chemother 49 2851 2856
56. Mansour MK Schlesinger LS Levitz SM 2002 Optimal T cell responses to Cryptococcus neoformans mannoprotein are dependent on recognition of conjugated carbohydrates by mannose receptors J Immunol 168 2872 2879
57. McClelland CM Chang YC Kwon-Chung KJ 2005 High frequency transformation of Cryptococcus neoformans and Cryptococcus gattii by Agrobacterium tumefaciens Fungal Genet Biol 42 904 913
58. van Meer G Holthuis JC 2000 Sphingolipid transport in eukaryotic cells Biochim Biophys Acta 1486 145 170
59. Mouyna I Fontaine T Vai M Monod M Fonzi WA Diaquin M Popolo L Hartland RP Latge JP 2000 Glycosylphosphatidylinositol-anchored glucanosyltransferases play an active role in the biosynthesis of the fungal cell wall J Biol Chem 275 14882 14889
60. Moyrand F Klaproth B Himmelreich U Dromer F Janbon G 2002 Isolation and characterization of capsule structure mutant strains of Cryptococcus neoformans Mol Microbiol 45 837 849
61. Moyrand F Chang YC Himmelreich U Kwon-Chung KJ Janbon G 2004 Cas3p belongs to a seven-member family of capsule structure designer proteins Eukaryot Cell 3 1513 1524
62. Munro S 2001 What can yeast tell us about N-linked glycosylation in the Golgi apparatus? FEBS Lett 498 223 227
63. Munro CA Gow NA 2001 Chitin synthesis in human pathogenic fungi Med Mycol 39 41 53
64. Oku M Warnecke D Noda T Muller F Heinz E Mukaiyama H Kato N Sakai Y 2003 Peroxisome degradation requires catalytically active sterol glucosyltransferase with a GRAM domain EMBO J 22 3231 3241
65. Olson GM Wang P Fox DS Buchanan KL 2005 Identification and characterization of mannosyltransferase mutants of Cryptococcus neoformans. 6th International Conference on Cryptococcus and Cryptococcosis. Boston, MA.
66. Oscarson S Alpe M Svahnberg P Nakouzi A Casadevall A 2005 Synthesis and immunological studies of glycoconjugates of Cryptococcus neoformans capsular glucuronoxylomannan oligosaccharide structures Vaccine 23 3961 3972
67. Patton JL Lester RL 1991 The phosphoinositol sphingolipids of Saccharomyces cerevisiae are highly localized in the plasma membrane J Bacteriol 173 3101 3108
68. Prill SK Klinkert B Timpel C Gale CA Schroppel K Ernst JF 2005 PMT family of Candida albicans five protein mannosyltransferase isoforms affect growth, morphogenesis and antifungal resistance Mol Microbiol 55 546 560
69. Qasba PK Ramakrishnan B Boeggeman E 2005 Substrate-induced conformational changes in glycosyltransferases Trends Biochem Sci 30 53 62
70. Reese AJ Doering TL 2003 Cell wall alpha-1,3-glucan is required to anchor the Cryptococcus neoformans capsule Mol Microbiol 50 1401 1409
71. Rittershaus PC Del Poeta M 2005 Sphingolipid-mediated host-pathogen interaction: the role of ceramides. 6th International Conference on Cryptococcus and Cryptococcosis Boston, MA
72. Ruiz-Herrera J San-Blas G 2003 Chitin synthesis as target for antifungal drugs Curr Drug Targets Infect Disord 3 77 91
73. Samuelson J Banerjee S Magnelli P Cui J Kelleher DJ Gilmore R Robbins PW 2005 The diversity of dolichol-linked precursors to Asn-linked glycans likely results from secondary loss of sets of glycosyltransferases Proc Natl Acad Sci USA 102 1548 1553
74. Shahinian S Bussey H 2000 Beta-1,6-Glucan synthesis in Saccharomyces cerevisiae Mol Microbiol 35 477 489
75. Singleton DR Masuoka J Hazen KC 2005 Surface hydrophobicity changes of two Candida albicans serotype B mnn4delta mutants Eukaryot Cell 4 639 648
76. Sommer U Liu H Doering TL 2003 An alpha-1,3-mannosyltransferase of Cryptococcus neoformans J Biol Chem 278 47724 47730
77. Stasyk OV Nazarko TY Stasyk OG Krasovska OS Warnecke D Nicaud JM Cregg JM Sibirny AA 2003 Sterol glucosyltransferases have different functional roles in Pichia pastoris and Yarrowia lipolytica Cell Biol Int 27 947 952
78. Strahl-Bolsinger S Gentzsch M Tanner W 1999 Protein O-mannosylation Biochim Biophys Acta 1426 297 307
79. Stratford M 1992 Yeast flocculation receptor definition by mnn mutants and concanavalin A Yeast 8 635 645
80. Thompson JR Douglas CM Li W Jue CK Pramanik B Yuan X Rude TH Toffaletti DL Perfect JR Kurtz M 1999 A glucan synthase FKS1 homolog in Cryptococcus neoformans is single copy and encodes an essential function J Bacteriol 181 444 453
81. Uemura S Kihara A Inokuchi J Igarashi Y 2003 Csg1p and newly identified Csh1p function in mannosylinositol phosphorylceramide synthesis by interacting with Csg2p J Biol Chem 278 45049 45055
82. Vaishnav VV Bacon BE O'Neill M Cherniak R 1998 Structural characterization of the galactoxylomannan of Cryptococcus neoformans Cap67 Carbohydr Res 306 315 330
83. Warnecke D Erdmann R Fahl A Hube B Muller F Zank T Zahringer U Heinz E 1999 Cloning and functional expression of UGT genes encoding sterol glucosyltransferases from Saccharomyces cerevisiae, Candida albicans, Pichia pastoris, and Dictyostelium discoideum J Biol Chem 274 13048 13059
84. Willer T Amselgruber W Deutzmann R Strahl S 2002 Characterization of POMT2, a novel member of the PMT protein O-mannosyltransferase family specifically localized to the acrosome of mammalian spermatids Glycobiology 12 771 783
85. Wright LC Payne J Santangelo RT Simpanya MF Chen SC Widmer F Sorrell TC 2004 Cryptococcal phospholipases a novel lysophospholipase discovered in the pathogenic fungus Cryptococcus gattii Biochem J 384 377 384