A point mutation in NEMO associated with anhidrotic ectodermal dysplasia with immunodeficiency pathology results in destabilization of the oligomer and reduces lipopolysaccharide- and tumor necrosis factor-mediated NF-κB activation

Journal of Biological Chemistry

Volumn 281, Issue 10, 2006, Pages 6334-6348

  Vinolo, Emilie ^a   Sebban, Hélène ^b   Chaffotte, Alain ^a   Israël, Alain ^a   Courtois, Gilles ^b   Véron, Michel ^a   Agou, Fabrice ^a  

^a INSTITUT PASTEUR   (France)

^b SAINT LOUIS HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

DISEASES; FLUORESCENCE; ONCOLOGY; PATHOLOGY; POLYPEPTIDES; PROTEINS;

ANHIDROTIC ECTODERMAL DYSPLASIA; OLIGOMERIZATION; PATHOGENIC MUTATION; TUMOR NECROSIS;

OLIGOMERS;

ALANINE; GLYCINE; I KAPPA B KINASE GAMMA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; OLIGOMER; TUMOR NECROSIS FACTOR ALPHA; ZINC FINGER PROTEIN; I KAPPA B KINASE; IKBKG PROTEIN, HUMAN; RECOMBINANT PROTEIN; TYROSINE;

AMINO ACID SUBSTITUTION; ANHIDROTIC ECTODERMAL DYSPLASIA; ANIMAL CELL; ARTICLE; B LYMPHOCYTE; CONFORMATIONAL TRANSITION; ENZYME ACTIVATION; ENZYME REGULATION; HELA CELL; HUMAN; HUMAN CELL; IMMUNE DEFICIENCY; MOUSE; NONHUMAN; OLIGOMERIZATION; PHENOTYPE; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN MODIFICATION; PROTEIN STABILITY; SIGNAL TRANSDUCTION; T LYMPHOCYTE; TEMPERATURE; UBIQUITINATION; AMINO ACID SEQUENCE; ANIMAL; CELL LINE; CHEMISTRY; CIRCULAR DICHROISM; DRUG ANTAGONISM; ECTODERMAL DYSPLASIA; GENETICS; ISOLATION AND PURIFICATION; METABOLISM; MOLECULAR GENETICS; PATHOLOGY; PHYSIOLOGY;

AMINO ACID SEQUENCE; ANIMALS; CELL LINE; CIRCULAR DICHROISM; ECTODERMAL DYSPLASIA; HUMANS; I-KAPPA B KINASE; IMMUNOLOGIC DEFICIENCY SYNDROMES; LIPOPOLYSACCHARIDES; MICE; MOLECULAR SEQUENCE DATA; NF-KAPPA B; POINT MUTATION; RECOMBINANT PROTEINS; TEMPERATURE; TUMOR NECROSIS FACTOR-ALPHA; TYROSINE; ZINC FINGERS;

EID: 33646548319     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M510118200     Document Type: Article

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