(Q)SAR studies to design new human choline kinase inhibitors as antiproliferative drugs

Current Medicinal Chemistry

Volumn 13, Issue 11, 2006, Pages 1231-1248

  Campos, J M ^a   Sanchez Martin R M ^a   Conejo Garcia A ^a   Entrena, A ^a   Gallo, M A ^a   Espinosa, A ^a  

^a Facultad de Farmacia   (Spain)

Author keywords

Ab initio calculations; Antitumor drugs; Bicyclophanes; Bispyridinium compounds; Bisquinolinium compounds; Choline Kinase; Cyclophanes; QSAR

Indexed keywords

ANILINE DERIVATIVE; ANTIMITOTIC AGENT; ANTINEOPLASTIC AGENT; AZEPINE DERIVATIVE; BIS(4 AMINOQUINOLINIUM) DERIVATIVE; CHOLINE KINASE INHIBITOR; CYCLOPHANE DERIVATIVE; CYCLOPROPANE DERIVATIVE; METHYLANILINE DERIVATIVE; PIPERIDINE DERIVATIVE; PROTEIN KINASE INHIBITOR; PYRIDINIUM DERIVATIVE; PYRROLIDINE DERIVATIVE; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; CANCER CHEMOTHERAPY; CYTOTOXICITY; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; GENE EXPRESSION REGULATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IC 50; IN VIVO STUDY; LD 50; LIPOPHILICITY; MASS SPECTROMETRY; MITOSIS INHIBITION; MUTATIONAL ANALYSIS; NEUROTOXICITY; NONHUMAN; PREDICTION; PROTON NUCLEAR MAGNETIC RESONANCE; QUANTITATIVE STRUCTURE ACTIVITY RELATION; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL PROLIFERATION; CHOLINE KINASE; ENZYME INHIBITORS; HUMANS; LETHAL DOSE 50; PYRIDINIUM COMPOUNDS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; QUINOLINIUM COMPOUNDS;

EID: 33646532895     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: 10.2174/092986706776872961     Document Type: Review

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