Concentration-dependence of aniline-induced methemoglobinemia in dogs: A derivation of an acute reference concentration

Toxicology

Volumn 214, Issue 1-2, 2005, Pages 140-150

  Pauluhn, Jürgen ^a  

^a BAYER PHARMA AG   (Germany)

Author keywords

Aniline; Benchmark analysis; Concentration time dependence; Dermal uptake; Inhalation uptake; Methemoglobin

Indexed keywords

ANILINE; METHEMOGLOBIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOLOGICAL ACTIVITY; BLOOD LEVEL; BODY MASS; CONCENTRATION RESPONSE; CYTOTOXICITY; DOG; DOSE TIME EFFECT RELATION; ERYTHROCYTE; EXPOSURE; FEMALE; HEAD; HEINZ BODY; HEMATOLOGY; HYPERVENTILATION; KINETICS; LIVER METABOLISM; MALE; MAXIMUM ALLOWABLE CONCENTRATION; METHEMOGLOBINEMIA; NONHUMAN; PRIORITY JOURNAL; REFERENCE VALUE; SKIN; VAPOR;

ANILINE COMPOUNDS; ANIMALS; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; ERYTHROCYTE COUNT; ERYTHROCYTES; FEMALE; HEMATOCRIT; HEMOGLOBINS; INHALATION EXPOSURE; MALE; METHEMOGLOBINEMIA; TIDAL VOLUME; TIME FACTORS; VOLATILIZATION;

CANIS FAMILIARIS;

EID: 25644460111     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2005.06.007     Document Type: Article

References (29)

1. J.C. Anders, and H. Chung Deficiencies and improvement of methemoglobin assay J. Anal. Toxicol. 8 1984 260 262
2. Anon. Aniline - acute exposure guideline levels Inhal. Toxicol. 13 Suppl. 2001 7 42
3. C. Barbas, M. Castro, B. Bonet, M. Viana, and E. Herrera Simultaneous determination of Vitamins A and E in rat tissues by high-performance liquid chromatography J. Chromatogr. A 778 1997 415 420
4. E. Beutler M.A. Lichtman B.S. Coller T.J. Kipps Williams Hematology fifth ed. 1995 Mc Graw-Hill Inc. New York
5. J.E. Bright, and T.C. Marrs A model for the induction of moderate levels of methemoglobinemia in man using 4-dimethylaminophenol Arch. Toxicol. 50 1982 57 64
6. J.M. Collins Inter-species differences in drug properties Chem. Biol. Interact. 134 2001 237 242
7. DFG, 2004. Deutsche Forschungsgemeinschaft - List of MAK and BAT Values 2004. Commission for the investigation of Health Hazards of Chemical Compounds in the Work Area. Report No.: 40. Wiley-VCH Verlag, Weinheim.
8. Directive 86/609/EEC, 1986. Guideline of the Council dated 24 November 1986 on the Reconciliation of Legal and Administrative Regulations of the Member Countries for the Protection of Animals used for Studies and other Scientific Purposes. J. Eur. Community, Legal Specifications L 358, 29.
9. European Chemical Bureau, Institute of for Health and Consumer Protection, 2004. European Union Risk Assessment Report EUR 21092EN, 1st priority list, vol. 50.
10. J.H. Harrison, and D.J. Jollow Role of aniline metabolites in aniline-induced hemolytic anemia J. Pharmacol. Exp. Ther. 238 1986 1045 1054
11. J.H. Harrison, and D.J. Jollow Contribution of aniline metabolites to aniline-induced methemoglobinemia Mol. Pharmacol. 32 1987 423 431
12. J.W. Harvey Erythrocyte metabolism J.J. Kaneko Clinical Biochemistry of Domestic Animals fourth ed. 1989 Academic Press New York 185 224.
13. F.P. Jenkins, J.A. Robinson, J.B.M. Gellatly, and G.W.A. Salmond The no-effect dose of aniline in human subjects and a comparison of aniline toxicity in man and the rat Fd. Cosmet. Toxicol. 10 1972 671 679
14. D.J. Jollow, and D.C. McMillan Oxidative stress, glucose-6-phosphate dehydrogenase and the red cell Adv. Exp. Med. Biol. 500 2001 595 605
15. M. Kiese Methemoglominemia: A Comprehensive Treatise - Causes, consequences, and correction of increased contents of ferrihemoglobin in blood 1974 CRC Press Inc. Cleveland, Ohio
16. Y.C. Kim, and G.P. Carlson The effect of an unusual workshift on chemical toxicity. II. Studies on the exposure of rats to aniline Fundam. Appl. Toxicol. 7 1986 144 152
17. M.C. Kohn, R.L. Melnick, F. Ye, and C.J. Portier Pharmacokinetics of sodium nitrite-induced methemoglobinemia in the rat Drug Metab. Dispos. 30 2002 676 683
18. J.K. Lang, and L. Packer Quantitative determination of Vitamin E and oxidized and reduced Coenzyme Q by high performance liquid chromatography with in-line ultraviolet and electrochemical detection J. Chromatogr. 385 1987 109 117
19. J. Lewalter, and U. Korallus Blood protein conjugates and acetylation of aromatic amines Int. Arch. Occup. Environ. Health 56 1985 179 196
20. S. McLean, G.A. Starmer, and J. Thomas Methaemoglobin fromation by aromatic amines J. Pharm. Pharmacol. 21 1969 441
21. Organization for Economic Cooperation and Development (OECD) - GLP, 1983. Publication of the German version of the OECD Principles of Good Laboratory Practice (GLP), Bundesanzeiger, 35, No. 42a, 2 March 1983.
22. J. Pauluhn, and U. Mohr Inhalation toxicity of 4-ethoxyaniline (p-phenetidine): critical analysis of results of subacute inhalation exposure studies in rats Inhal. Toxicol. 13 2001 993 1013
23. J. Pauluhn Aniline-induced methemoglobinemia in dogs: pitfalls of route-to-route extrapolations Inhal. Toxicol. 14 2002 959 973
24. J. Pauluhn Subacute inhalation toxicity of aniline in rats: analysis of time-dependence and concentration-dependence of hematotoxic and splenic effects Toxicol. Sci. 81 2004 198 215
25. R.J. Remiarz, J.K. Argawal, F.R. Quant, and G.J. Sem V.A. Marple B.Y.H. Liu A Real-Time Aerodynamic Particle Size Analyzer in Aerosols in the Mining and Industrial Work Environments 1983 Ann Arbor Science Publ. Inc. Mich 879 895
26. R. Richterich, and J.P. Colombo Klinische Chemie, Methämolgobin (Hämiglobin) Spektrophotometrie 1978 S. Karger Verlag München pp. 441-443
27. G.A. Rockwood, K.R. Armstrong, and S.I. Baskin Species comparison of methemoglobin reductase Exp. Biol. Med. 228 2003 79 83
28. C.F. Simpson Rhodanile Blue: a rapid and selective stain for Heinz bodies Stain Technol. 45 1970 221 223
29. WHO/FAO, 2004. Pesticide residues in food. Report of the Joint Meeting of the FAO Panel of Experts on Pesticides residues in Food and the Environment and the WHO Core Assessment Group on Pesticide Residues, Rome, Italy, 20-29 September 2004. FAO Plant Production and Protection Paper 178, pp. 7. World Health Organization and Food and Agriculture Organization of the United Nations, Rome, 2004.