메뉴 건너뛰기




Volumn 49, Issue 6, 2006, Pages 1338-1348

Insights into the role of anaplerosis in insulin secretion: A 13C NMR study

Author keywords

Anaplerosis; Aspartate; Insulin secretion; Metabolism; NMR spectroscopy

Indexed keywords

ASPARTIC ACID; CARBON 13; GLUCOSE; INSULIN; PYRUVATE CARBOXYLASE; PYRUVATE DEHYDROGENASE; PYRUVIC ACID;

EID: 33646506161     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-006-0216-5     Document Type: Article
Times cited : (18)

References (37)
  • 2
    • 0030067124 scopus 로고    scopus 로고
    • A lesson in metabolic regulation inspired by the glucokinase glucose sensor paradigm
    • Matschinsky FM (1996) A lesson in metabolic regulation inspired by the glucokinase glucose sensor paradigm. Diabetes 45:223-241
    • (1996) Diabetes , vol.45 , pp. 223-241
    • Matschinsky, F.M.1
  • 3
    • 0029071517 scopus 로고
    • Metabolic coupling factors in pancreatic β-cell signal transduction
    • Newgard CB, McGarry JD (1995) Metabolic coupling factors in pancreatic β-cell signal transduction. Ann Rev Biochem 64:689-719
    • (1995) Ann Rev Biochem , vol.64 , pp. 689-719
    • Newgard, C.B.1    McGarry, J.D.2
  • 4
    • 0029932643 scopus 로고    scopus 로고
    • New insights into pancreatic β-cell metabolic signaling in insulin secretion
    • Prentki M (1996) New insights into pancreatic β-cell metabolic signaling in insulin secretion. Eur J Endocrin 134:272-286
    • (1996) Eur J Endocrin , vol.134 , pp. 272-286
    • Prentki, M.1
  • 5
    • 0345548707 scopus 로고    scopus 로고
    • 13C NMR analysis reveals a link between L-glutamine metabolism, D-glucose metabolism and γ-glutamyl cycle activity in a clonal pancreatic beta-cell line
    • 13C NMR analysis reveals a link between L-glutamine metabolism, D-glucose metabolism and γ-glutamyl cycle activity in a clonal pancreatic beta-cell line. Diabetologia 46:1512-1521
    • (2003) Diabetologia , vol.46 , pp. 1512-1521
    • Brennan, L.1    Corless, M.2    Hewage, C.3
  • 6
    • 0036263720 scopus 로고    scopus 로고
    • A nuclear magnetic resonance-based demonstration of substantial oxidative L-alanine metabolism and L-alanine-enhanced glucose metabolism in a clonal pancreatic β-cell line
    • Brennan L, Shine A, Hewage C et al (2002) A nuclear magnetic resonance-based demonstration of substantial oxidative L-alanine metabolism and L-alanine-enhanced glucose metabolism in a clonal pancreatic β-cell line. Diabetes 51:1714-1721
    • (2002) Diabetes , vol.51 , pp. 1714-1721
    • Brennan, L.1    Shine, A.2    Hewage, C.3
  • 8
    • 0036724236 scopus 로고    scopus 로고
    • The succinate mechanism of insulin release
    • Fahien LA, MacDonald MJ (2002) The succinate mechanism of insulin release. Diabetes 51:2669-2676
    • (2002) Diabetes , vol.51 , pp. 2669-2676
    • Fahien, L.A.1    MacDonald, M.J.2
  • 9
    • 0034072556 scopus 로고    scopus 로고
    • Glucose-regulated anaplerosis and cataplerosis in pancreatic β-cells: Possible implication of a pyruvate/citrate shuttle in insulin secretion
    • Farfari S, Schultz V, Corkey B, Prentki M (2000) Glucose-regulated anaplerosis and cataplerosis in pancreatic β-cells: possible implication of a pyruvate/citrate shuttle in insulin secretion. Diabetes 49:718-726
    • (2000) Diabetes , vol.49 , pp. 718-726
    • Farfari, S.1    Schultz, V.2    Corkey, B.3    Prentki, M.4
  • 10
    • 0037022527 scopus 로고    scopus 로고
    • 13C NMR isotopomer analysis reveals a connection between pyruvate cycling and glucose-stimulated insulin secretion (GSIS)
    • USA
    • 13C NMR isotopomer analysis reveals a connection between pyruvate cycling and glucose-stimulated insulin secretion (GSIS). Proc Natl Acad Sci USA 99:2708-2713
    • (2002) Proc Natl Acad Sci , vol.99 , pp. 2708-2713
    • Lu, D.H.1    Mulder, H.2    Zhao, P.3
  • 12
    • 0029347470 scopus 로고
    • 31P NMR spectroscopic studies of immunoisolated insulin-secreting AtT-20 cells
    • 31P NMR spectroscopic studies of immunoisolated insulin-secreting AtT-20 cells. Biotechn Bioeng 47:431-443
    • (1995) Biotechn Bioeng , vol.47 , pp. 431-443
    • Constantinidis, I.1    Sambanis, A.2
  • 13
    • 0031936224 scopus 로고    scopus 로고
    • Noninvasive monitoring of tissue-engineered constructs by nuclear magnetic resonance methodologies
    • Constantinidis I, Sambanis A (1998) Noninvasive monitoring of tissue-engineered constructs by nuclear magnetic resonance methodologies. Tissue Engin 4:9-17
    • (1998) Tissue Engin , vol.4 , pp. 9-17
    • Constantinidis, I.1    Sambanis, A.2
  • 15
    • 0035680875 scopus 로고    scopus 로고
    • NMR spectroscopy in beta cell engineering and islet transplantation
    • Papas KK, Colton CK, Gounarides JS et al (2001) NMR spectroscopy in beta cell engineering and islet transplantation. Ann N Y Acad Sci 944:96-119
    • (2001) Ann N Y Acad Sci , vol.944 , pp. 96-119
    • Papas, K.K.1    Colton, C.K.2    Gounarides, J.S.3
  • 20
    • 0742323131 scopus 로고    scopus 로고
    • 13C isotopomer analysis of complex metabolic conditions: Substrate oxidation, multiple pyruvate cycles, and gluconeogenesis
    • 13C isotopomer analysis of complex metabolic conditions: substrate oxidation, multiple pyruvate cycles, and gluconeogenesis. Metab Eng 6:12-24
    • (2004) Metab Eng , vol.6 , pp. 12-24
    • Sherry, A.D.1    Jeffrey, F.M.H.2    Malloy, C.R.3
  • 23
    • 0025827061 scopus 로고
    • 2+, oxygen consumption, and insulin secretion in glucose stimulated rat pancreatic islets
    • 2+, oxygen consumption, and insulin secretion in glucose stimulated rat pancreatic islets. J Biol Chem 266:9314-9319
    • (1991) J Biol Chem , vol.266 , pp. 9314-9319
    • Longo, E.L.1    Tornheim, K.2    Deeney, J.T.3
  • 24
    • 0035030843 scopus 로고    scopus 로고
    • Comparative functional study of clonal insulin-secreting cells cultured in five commercially available tissue culture media
    • Hamid M, McClusky JT, McClenaghan NH, Flatt PR (2001) Comparative functional study of clonal insulin-secreting cells cultured in five commercially available tissue culture media. Cell Transplant 10:153-159
    • (2001) Cell Transplant , vol.10 , pp. 153-159
    • Hamid, M.1    McClusky, J.T.2    McClenaghan, N.H.3    Flatt, P.R.4
  • 25
    • 0030765842 scopus 로고    scopus 로고
    • Glucose-induced insulin secretion in INS-1 cells depends on factors present in fetal calf serum and rat islet-conditioned media
    • Sekine N, Fasolato C, Pralong WF, Theler JM, Wollheim CB (1997) Glucose-induced insulin secretion in INS-1 cells depends on factors present in fetal calf serum and rat islet-conditioned media. Diabetes 46:1424-1433
    • (1997) Diabetes , vol.46 , pp. 1424-1433
    • Sekine, N.1    Fasolato, C.2    Pralong, W.F.3    Theler, J.M.4    Wollheim, C.B.5
  • 26
    • 0036095159 scopus 로고    scopus 로고
    • Intracellular pH plays a critical role in glucose-induced time-dependent potentiation of insulin release in rat islets
    • Gunawardana SC, Sharp GWG (2002) Intracellular pH plays a critical role in glucose-induced time-dependent potentiation of insulin release in rat islets. Diabetes 51:105-113
    • (2002) Diabetes , vol.51 , pp. 105-113
    • Gunawardana, S.C.1    Sharp, G.W.G.2
  • 28
    • 0030062465 scopus 로고    scopus 로고
    • Simultaneous extraction of cellular lipids and water-soluble metabolites: Evaluation by NMR spectroscopy
    • Tyagi RK, Azrad A, Degani H, Salomon Y (1996) Simultaneous extraction of cellular lipids and water-soluble metabolites: evaluation by NMR spectroscopy. Magn Reson Med 35:194-200
    • (1996) Magn Reson Med , vol.35 , pp. 194-200
    • Tyagi, R.K.1    Azrad, A.2    Degani, H.3    Salomon, Y.4
  • 29
    • 0021946270 scopus 로고
    • Do pancreatic islets contain significant amounts of phosphoenolpyruvate carboxykinase or ferroactivator activity?
    • MacDonald MJ, Chang CM (1985) Do pancreatic islets contain significant amounts of phosphoenolpyruvate carboxykinase or ferroactivator activity? Diabetes 34:246-250
    • (1985) Diabetes , vol.34 , pp. 246-250
    • MacDonald, M.J.1    Chang, C.M.2
  • 30
    • 0021857858 scopus 로고
    • Evidence for phosphorylation of pancreatic islet pyruvate kinase
    • MacDonald MJ, Kowluru A, Chang CM (1985) Evidence for phosphorylation of pancreatic islet pyruvate kinase. Metabolism 34:600-603
    • (1985) Metabolism , vol.34 , pp. 600-603
    • MacDonald, M.J.1    Kowluru, A.2    Chang, C.M.3
  • 31
    • 0026546719 scopus 로고
    • Lack of glyconeogenesis in pancreatic islets: Expression of gluconeogenic enzyme genes in islets
    • MacDonald MJ, McKenzie DI, Walker TM, Kaysen JH (1992) Lack of glyconeogenesis in pancreatic islets: expression of gluconeogenic enzyme genes in islets. Horm Metab Res 24:158-160
    • (1992) Horm Metab Res , vol.24 , pp. 158-160
    • MacDonald, M.J.1    McKenzie, D.I.2    Walker, T.M.3    Kaysen, J.H.4
  • 33
    • 0033540037 scopus 로고    scopus 로고
    • Mitochondrial glutamate acts as a messenger in glucose-induced insulin exocytosis
    • Maechler P, Wollheim CB (1999) Mitochondrial glutamate acts as a messenger in glucose-induced insulin exocytosis. Nature 402:685-689
    • (1999) Nature , vol.402 , pp. 685-689
    • Maechler, P.1    Wollheim, C.B.2
  • 34
    • 0037031896 scopus 로고    scopus 로고
    • The elevation of glutamate content and the amplification of insulin secretion in glucose-stimulated pancreatic islets are not causally related
    • Bertrand G, Ishiyama N, Nenquin M, Ravier MA, Henquin JC (2002) The elevation of glutamate content and the amplification of insulin secretion in glucose-stimulated pancreatic islets are not causally related. J Biol Chem 277:32883-32891
    • (2002) J Biol Chem , vol.277 , pp. 32883-32891
    • Bertrand, G.1    Ishiyama, N.2    Nenquin, M.3    Ravier, M.A.4    Henquin, J.C.5
  • 35
    • 0034602141 scopus 로고    scopus 로고
    • Glutamate is not a messenger in insulin secretion
    • MacDonald MJ, Fahien LA (2000) Glutamate is not a messenger in insulin secretion. J Biol Chem 275:34025-34027
    • (2000) J Biol Chem , vol.275 , pp. 34025-34027
    • MacDonald, M.J.1    Fahien, L.A.2
  • 36
    • 0031595179 scopus 로고    scopus 로고
    • 13C]aspartate metabolism in cultured cortical astrocytes and cerebellar granule neurons studied by NMR spectroscopy
    • 13C]aspartate metabolism in cultured cortical astrocytes and cerebellar granule neurons studied by NMR spectroscopy. Glia 23:271-277
    • (1998) Glia , vol.23 , pp. 271-277
    • Bakken, I.J.1    White, L.R.2    Aasly, J.3    Unsgard, G.4    Sonnewald, U.5
  • 37
    • 0024548920 scopus 로고
    • Effect of esters of succinic acid and other citric acid cycle intermediates on insulin release and inositol phosphate formation by pancreatic islets
    • MacDonald MJ, Fahien LA, Mertz RJ, Rana R (1989) Effect of esters of succinic acid and other citric acid cycle intermediates on insulin release and inositol phosphate formation by pancreatic islets. Arch Biochem Biophys 269:400-406
    • (1989) Arch Biochem Biophys , vol.269 , pp. 400-406
    • MacDonald, M.J.1    Fahien, L.A.2    Mertz, R.J.3    Rana, R.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.