Antiproliferative properties of padma lax and its components ginger and elecampane

Forschende Komplementarmedizin

Volumn 13, Issue SUPPL. 1, 2006, Pages 18-22

  Hofbauer, Sebastian ^a   Kainz, Verena ^a   Golser, Leopold ^a   Klappacher, Michaela ^a   Kiesslich, Tobias ^b   Heidegger, Wilhelm ^b   Krammer, Barbara ^b   Hermann, Anton ^a   Weiger, Thomas M ^a,b  

^a Division of Animal Physiology   (Austria)

^b UNIVERSITY OF SALZBURG   (Austria)

Author keywords

Apoptosis; Padma Lax; Proliferation; Synergism; Tibetan medicine

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 7; GINGER EXTRACT; HERBACEOUS AGENT; LAXATIVE; PADMA LAX; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE; CELL PROLIFERATION; CHINA; CONSTIPATION; CONTROLLED STUDY; DRUG POTENTIATION; ELECAMPANE; GINGER; GLIOMA CELL; HUMAN; HUMAN CELL; IRRITABLE COLON; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; TIBETAN MEDICINE; TUMOR CELL;

CELL DIVISION; CELLS, CULTURED; CONSTIPATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; ETHANOL; GINGER; HUMANS; INTESTINAL NEOPLASMS; MEDICINE, TIBETAN TRADITIONAL; PHYTOTHERAPY; PLANT EXTRACTS; TIME FACTORS;

EID: 33646497197     PISSN: 16614119     EISSN: 16614127     Source Type: Journal    
DOI: 10.1159/000091147     Document Type: Article

References (42)

1. Jacobs EJ, White E: Constipation, laxative use, and colon cancer among middle-aged adults. Epidemiology 1998;9:385-391.
2. Roberts MC, Millikan RC, Galanko JA, Martin C, Sandler RS: Constipation, laxative use, and colon cancer in a North Carolina population. Am J Gastroenterol 2003;98:857-864.
3. Fluck H, Bubb WP: [A lamaistic prescription-formula for the treatment of chronic constipation]. Schweiz Rundsch Med Prax 1970;59:1190-1193.
4. Sallon S, Ben Arye E, Davidson R, Shapiro H, Ginsberg G, Ligumsky M: A novel treatment for constipation-predominant irritable bowel syndrome using Padma Lax, a Tibetan herbal formula. Digestion 2002;65:161-171.
5. Arimochi H, Morita K: High salt culture conditions suppress proliferation of rat c6 glioma cell by arresting cell-cycle progression at s-phase. J Mol Neurosci 2005;27:293-302.
6. Cechin SR, Dunkley PR, Rodnight R: Signal transduction mechanisms involved in the proliferation of C6 glioma cells induced by lysophosphatidic acid. Neurochem Res 2005;30:603-611.
7. Chen YJ, Lin JK, Lin-Shiau SY: Proliferation arrest and induction of CDK inhibitors p21 and p27 by depleting the calcium store in cultured C6 glioma cells. Eur J Cell Biol 1999;78:824-831.
8. Claes P, Grobben B, Van Kolen K, Roymans D, Siegers H: P2Y(AC)(-)-receptor agonists enhance the proliferation of rat C6 glioma cells through activation of the p42/44 mitogen-activated protein kinase. Br J Pharmacol 2001;134:402-408.
9. Fowler CJ, Jonsson KO, Andersson A, Juntunen J, Jarvinen T, Vandevoorde S, Lambert DM, Jerman JC, Smart D: Inhibition of C6 glioma cell proliferation by anandamide, 1-arachidonoylglycerol, and by a water soluble phosphate ester of anandamide: variability in response and involvement of arachidonic acid. Biochem Pharmacol 2003;66:757-767.
10. Hochreiter R, Weiger TM, Colombatto S, Langer T, Thomas TJ, Cabella C, Heidegger W, Grillo MA, Hermann A: Long chain diamines inhibit growth of C6 glioma cells according to their hydrophobicity. An in vitro and molecular modeling study. Naunyn Schmiedebergs Arch Pharmacol 2000;361:235-246.
11. Jacobsson SO, Wallin T, Fowler CJ: Inhibition of rat C6 glioma cell proliferation by endogenous and synthetic cannabinoids. Relative involvement of cannabinoid and vanilloid receptors. J Pharmacol Exp Ther 2001;299:951-959.
12. Lung HL, Shan SW, Tsang D, Leung KN: Tumor necrosis factor-alpha mediates the proliferation of rat C6 glioma cells via beta-adrenergic receptors. J Neuroimmunol 2005;166:102-112.
13. Rouzaire-Dubois B, Milandri JB, Bostel S, Dubois JM: Control of cell proliferation by cell volume alterations in rat C6 glioma cells. Pflugers Arch 2000;440:881-888.
14. Watanabe T, Katayama Y, Kimura S, Yoshino A: Control of proliferation and survival of C6 glioma cells with modification of the nerve growth factor autocrine system. J Neurooncol 1999;41:121-128.
15. Bottenstein JE, Sato G: Cell Culture in the Neurosciences New York, Plenum, 1985.
16. Reile H, Bimbock H, Bernhardt G, Spruss T, Schonenberger H: Computerized determination of growth kinetic curves and doubling times from cells in microculture. Anal Biochem 1990;187:262-267.
17. Delaney CA, Pavlovic D, Hoorens A, Pipeleers DG, Eizirik DL: Cytokines induce deoxyribonucleic acid strand breaks and apoptosis in human pancreatic islet cells. Endocrinology 1997;138:2610-2614.
18. Hoorens A, Van de CM, Kloppel G, Pipeleers D: Glucose promotes survival of rat pancreatic beta cells by activating synthesis of proteins which suppress a constitutive apoptotic program. J Clin Invest 1996;98:1568-1574.
19. Duchen MR, Biscoe TJ: Relative mitochondrial membrane potential and [Ca2+]i in type I cells isolated from the rabbit carotid body. J Physiol 1992;450:33-61.
20. Smith PK, Krohn RI, Hermanson GT, Mallia AK, Gartner FH, Provenzano MD, Fujimoto EK, Goeke NM, Olson BJ, Klenk DC: Measurement of protein using bicinchoninic acid. Anal Biochem 1985;150:76-85.
21. Halliwell B: Oxidative stress in cell culture: an under-appreciated problem? FEBS Lett 2003;540:3-6.
22. Seiler N, Raul F: Polyamines and apoptosis. J Cell Mol Med 2005;9:623-642.
23. Thomas T, Thomas TJ: Polyamines in cell growth and cell death: molecular mechanisms and therapeutic applications. Cell Mol Life Sci 2001;58:244-258.
24. Niskanen E, Wharton WW, III: Diamine oxidase is important in assessment of polyamine effects on hemopoietic cell proliferation in vitro. In Vitro Cell Dev Biol 1987;23:257-260.
25. Pucci B, Kasten M, Giordano A: Cell cycle and apoptosis. Neoplasia 2000;2:291-299.
26. Hsu MH, Kuo SC, Chen CJ, Chung JG, Lai YY, Huang LJ: 1-(3,4- Dimethoxyphenyl)-3,5-dodecene-dione (I6) induces G1 arrest and apoptosis in human promyelocytic leukemia HL-60 cells. Leuk Res 2005;29:1399-1406.
27. Kim EC, Min JK, Kim TY, Lee SJ, Yang HO, Han S, Kim YM, Kwon YG: [6]-Gingerol, a pungent ingredient of ginger, inhibits angiogenesis in vitro and in vivo. Biochem Biophys Res Commun 2005;335:300-308.
28. Wang G, Li X, Huang F, Zhao J, Ding H, Cunningham C, Coad JE, Flynn DC, Reed E, Li QQ: Anti-tumor effect of beta-elemene in non-small-cell lung cancer cells is mediated via induction of cell cycle arrest and apoptotic cell death. Cell Mol Life Sci 2005;62:881-893.
29. Wei QY, Ma JP, Cai YJ, Yang L, Liu ZL: Cytotoxic and apoptotic activities of diarylheptanoids and gingerol-related compounds from the rhizome of Chinese ginger. J Ethnopharmacol 2005;102:177-184.
30. Konishi T, Shimada Y, Nagao T, Okabe H, Konoshima T: Antiproliferative sesquiterpene lactones from the roots of Inula helenium. Biol Pharm Bull 2002;25:1370-1372.
31. Chai PC, Long LH, Halliwell B: Contribution of hydrogen peroxide to the cytotoxicity of green tea and red wines. Biochem Biophys Res Commun 2003;304:650-654.
32. Bai H, Konat GW: Hydrogen peroxide mediates higher order chromatin degradation. Neurochem Int 2003;42:123-129.
33. Porter AG, Janicke RU: Emerging roles of caspase-3 in apoptosis. Cell Death Differ 1999;6:99-104.
34. Meller R, Skradski SL, Simon RP, Henshall DC: Expression, proteolysis and activation of caspases 6 and 7 during rat C6 glioma cell apoptosis. Neurosci Lett 2002;324:33-36.
35. Mohamad N, Gutierrez A, Nunez M, Cocca C, Martin G, Cricco G, Medina V, Rivera E, Bergoc R: Mitochondrial apoptotic pathways. Biocell 2005;29:149-161.
36. Kim R, Emi M, Tanabe K: Caspase-dependent and -independent cell death pathways after DNA damage (Review). Oncol Rep 2005;14:595-599.
37. Kroemer G, Martin SJ: Caspase-independent cell death. Nat Med 2005;11:725-730.
38. Broker LE, Kruyt FA, Giaccone G: Cell death independent of caspases: a review. Clin Cancer Res 2005;11:3155-3162.
39. Alonso M, Tamasdan C, Miller DC, Newcomb EW: Flavopiridol induces apoptosis in glioma cell lines independent of retinoblastoma and p53 tumor suppressor pathway alterations by a caspase-independent pathway. Mol Cancer Ther 2003;2:139-150.
40. Komiya T, Fusetani N, Matsunaga S, Kubo A, Kaye FJ, Kelley MJ, Tamura K, Yoshida M, Fukuoka M, Nakagawa K: Ritterazine B, a new cytotoxic natural compound, induces apoptosis in cancer cells. Cancer Chemother Pharmacol 2003;51:202-208.
41. Jaattela M, Cande C, Kroemer G: Lysosomes and mitochondria in the commitment to apoptosis: a potential role for cathepsin D and AIF. Cell Death Differ 2004;11:135-136.
42. Cande C, Cohen I, Daugas E, Ravagnan L, Larochette N, Zamzami N, Kroemer G: Apoptosis-inducing factor (AIF): a novel caspase-independent death effector released from mitochondria. Biochimie 2002;84:215-222.