3D-QSAR study on heterocyclic topoisomerase II inhibitors using CoMSIA

SAR and QSAR in Environmental Research

Volumn 17, Issue 2, 2006, Pages 121-132

  Tekiner Gulbas, B ^a   Temiz Arpaci, O ^a   Yildiz, I ^a   Aki Sener, E ^a   Yalcin, I ^a  

^a ANKARA UNIVERSITY   (Turkey)

Author keywords

3D QSAR; Benzimidazoles; Benzothiazoles; Benzoxazoles; CoMSIA; Oxazolo(4,5 b)pyridines; Topoisomerase II inhibitors

Indexed keywords

COMPUTATIONAL CHEMISTRY; HYDROPHOBICITY; SYNTHESIS (CHEMICAL);

3D-QSAR; BENZIMIDAZOLES; BENZOTHIAZOLES; BENZOXAZOLE; COMPARATIVE-MOLECULAR-SIMILARITY-INDICES ANALYSIS; HYDROPHOBICS; OXAZOLO(4,5-B)PYRIDINE; QSAR STUDIES; TOPOISOMERASE II; TOPOISOMERASE II INHIBITOR;

PYRIDINE;

EUKARYOTA;

EID: 33646490574     PISSN: 1062936X     EISSN: 1029046X     Source Type: Journal    
DOI: 10.1080/10659360600636105     Document Type: Article

References (28)

1. J. Wang. Annu. Rev. Biochem., 54, 665 (1985).
2. N.R. Cozzaelli. Cell, 22, 327 (1980).
3. N. Osheroff, E.L. Zechiedrich, K.C. Gale. Bioessays, 13, 269 (1991).
4. P.M. Patt, I.D. Hickson. Biochem. J., 303, 681 (1994).
5. J.M. Berger, J.C. Wang. Curr. Opin. Struct. Biol., 6, 84 (1996).
6. L.E. Dillehay, D. Jacobson-Kram, J.R. Williams. Mutat. Res., 215, 15 (1989).
7. J.L. Nitiss. Adv. Pharmacol., 29, 103 (1994).
8. T. Uemura, M. Yanagida. EMBO J., 3, 1737 (1984).
9. T. Goto, J.C. Wang. Cell, 36, 1073 (1984).
10. A.H. Corbett, N. Osheroff. Chem. Res. Toxicol., 6, 585 (1993).
11. Y. Pommier, F. Leteurtre, M.R. Fesen, A. Fujimori, R. Bertrand, E. Solary, G. Kohlhagen, K.W. Kohn. Cancer Invest., 12, 530 (1994).
12. D.M. Sullivan, M.D. Latham, W.E. Ross. Cancer Res., 47, 3973 (1987).
13. A. Pinar, P. Yurdakul, I. Yildiz, O. Temiz-Arpaci, N.L. Acan, E. Aki-Sener, I. Yalcin. Biochem. Biophys. Res. Comm., 317, 670 (2004).
14. D.J.W. Blum, R.E. Speece. Environ. Sci. Technol., 24, 284 (1990).
15. A. Agarwal, E.W. Taylor. J. Comput. Chem., 14, 237 (1993).
16. K. Hasegawa, M. Arakawa, K. Funatsu. Chemom. Intell. Lab. Syst., 50, 253 (1999).
17. H. Liu, M. Ji, H.L. Jiang. Bioorg. Med. Chem. Lett., 10, 2153 (2000).
18. D.R. Cramer, D.E. Paterson, J.D. Bunce. J. Am. Chem. Soc., 110, 5959 (1988).
19. G. Klebe, U. Abraham, T. Mietzner. J. Med. Chem., 37, 4130 (1994).
20. G. Klebe, U.Abraham. J. Comput. Aided Mol. Des., 13, 1 (1999).
21. O. Temiz-Arpaci, B. Tekiner-Gulbas, I. Yildiz, E. Aki-Sener, I. Yalcin. Bioorg. Med. Chem., 13, 6354 (2005).
22. N. Osheroff, E.R. Shelton, D. Brutlag. J. Biol. Chem., 258, 9536 (1983).
23. M. Bohm, J. Sturzebecher, G. Klebe. J. Med. Chem., 42, 458 (1999).
24. T. Hou, Y. Li, N. Liao, X. Xu. J. Mol. Model., 6, 438 (2000).
25. Sybyl 7.0, Tripos Inc., St. Louis, USA.
26. P. Geladi. J. Chemom., 2, 231 (1998).
27. A. Agarwal, P.P. Pearson, E.W. Taylor, H.B. Li, T. Dahlgren, M. Herslof, Y. Yang, G. Lambert, D.L. Nelson, J.W. Regan. J. Med. Chem., 36, 4006 (1993).
28. N. Baurin, E. Vangrevelinghe, L. Morin-Allory, J.Y. Merour, P. Renard, M. Payard, G. Guillaumet, C. Marot. J. Med. Chem., 43, 1109 (2000).