Polar, functionalized guanine-O6 derivatives resistant to repair by O6-alkylguanine-DNA alkyltransferase: implications for the design of DNA-modifying drugs

European Journal of Medicinal Chemistry

Volumn 41, Issue 3, 2006, Pages 330-339

  Pletsas, Dimitrios ^a   Wheelhouse, Richard T ^a   Pletsa, Vassiliki ^b   Nicolaou, Anna ^a   Jenkins, Terence C ^c   Bibby, Michael C ^a   Kyrtopoulos, Soterios A ^b  

^a UNIVERSITY OF BRADFORD   (United Kingdom)

^b Ethniko Idrima Erevnon   (Greece)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

DNA repair; Drug design; O6 alkylguanine DNA alkyltransferase; Purine

Indexed keywords

2 [2 AMINO 6 (2 AMINOETHOXY)PURIN 9 YLMETHOXY]ETHANOL; 2 [2 AMINO 6 (2 DIMETHYLAMINOETHOXY)PURIN 9 YLMETHOXY]ETHANOL; 2 [2 AMINO 6 (2 HYDROXYETHOXY)PURIN 9 YLMETHOXY]ETHANOL; 2 [2 AMINO 9 (2 HYDROXYETHOXYMETHYL) 9H PURIN 6 YLOXYL]ACETIC ACID AMMONIUM; 6 O ALKYLGUANINE DNA ALKYLTRANSFERASE; 6 O BENZYLGUANINE; [2 AMINO 9 (2 HYDROXYETHOXYMETHYL) 9H PURIN 6 YLOXYL]ACETIC ACID; ALKYLATING AGENT; ANTINEOPLASTIC AGENT; GUANINE DERIVATIVE; PURINE DERIVATIVE; UNCLASSIFIED DRUG;

ACIDITY; ARTICLE; CANCER CELL CULTURE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; DRUG DESIGN; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HYDROGEN BOND; PROTEIN EXPRESSION; PROTEIN MODIFICATION;

CRYSTALLOGRAPHY, X-RAY; DNA; DNA REPAIR ENZYMES; DRUG DESIGN; GUANINE; HUMANS; MODELS, BIOLOGICAL; MOLECULAR STRUCTURE; MUTATION; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; PURINES; SUBSTRATE SPECIFICITY;

EID: 33646469000     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2005.11.007     Document Type: Article

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