Highly oligomeric procyanidins ameliorate experimental autoimmune encephalomyelitis via suppression of Th1 immunity

Journal of Immunology

Volumn 176, Issue 10, 2006, Pages 5797-5804

  Miyake, Mika ^a   Sasaki, Katsunori ^a   Ide, Kazuki ^a   Matsukura, Yasuko ^a   Shijima, Kumiko ^a   Fujiwara, Daisuke ^a  

^a KIRIN BREWERY CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DRACONTIUM LORETENSE EXTRACT; GUAVA EXTRACT; HERBACEOUS AGENT; HYMENAEA COURBARIL EXTRACT; PHYSALIS ANGULATA EXTRACT; POLYPODIUM LEPIDOPTERIS EXTRACT; PROCYANIDIN DERIVATIVE; UNCARIA TOMENTOSA EXTRACT; UNCLASSIFIED DRUG;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN PRESENTATION; ARTICLE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; DEMYELINATION; DENDRITIC CELL; DISEASE MODEL; DRACONTIUM LORETENSE; DRUG EFFECT; DRUG EFFICACY; GUAVA; HERB; HYMENAEA COURBARIL; MACROPHAGE; MALE; MOUSE; NONHUMAN; PHYSALIS ANGULATA; POLYMERIZATION; POLYPODIUM LEPIDOPTERIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCORING SYSTEM; SPLEEN CELL; TH1 CELL; UNCARIA TOMENTOSA;

EID: 33646466627     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.176.10.5797     Document Type: Article

References (35)

1. Steinman, L. 2001. Multiple sclerosis; a two-stage disease. Nat. Immunol 2: 762-764.
2. Steinman, L. 1996. Multiple sclerosis: a coordinated immunological attack against myelin in the central nervous system. Cell 85: 299-302.
3. Yushchenko, M., M. Mäder, E. Elitok, A. Bitsch, A. Dressel, H. Tumani, T. Bogumil, B. Kitze, S. Poser, and F. Weber. 2003. Interferon-β-1 b decreased matrix metalloproteinase-9 serum levels in primary progressive multiple sclerosis. J. Neurol. 250: 1224-1228.
4. Giannelli, G., A. D. Marzo, C. Scagnolari, C. Bergamini, E. Fransvea, F. Bagnato, F. Bellomi, E. Millefiorini, C. Gasperini, S. Antonaci, and G. Antonelli. 2002. Proteolytic balance in patients with multiple sclerosis during interferon treatment. J. Interferon Cytokine Res. 22: 689-692.
5. Yasuda, C. L., A. Al-Sabbagh, E. C. Oliveir, B. M. Diaz-Bardales, A. A. Garcia, and L. M. Santos. 1999. Interferon β modulates experimental autoimmune encephalomyelitis by altering the pattern of cytokine secretion. Immunol Invest. 28: 115-126.
6. + T-cell subsets in autoimmunity. Curr. Opin. Immunol. 9: 872-883.
7. Ruddle, N. H., C. M. Bergman, K. M. McGrath, E. G. Lingenheld, M. L. Grunnet, S. J. Padula, and R. B. Clark. 1990. An antibody to lymphotoxin and tumor necrosis factor prevents transfer of experimental allergic encephalomyelitis. J. Exp. Med. 172: 1193-1200.
8. Selmaj, K., C. S. Raine, and A. H. Cross. 1991. Anti-tumor necrosis factor therapy abrogates autoimmune demyelination. Ann. Neurol. 30: 694-700.
9. Selmaj, K., W. Papierz, A. Glabinski. and T. Kohno. 1995. Prevention of chronic relapsing experimental autoimmune encephalomyelitis by soluble tumor necrosis factor receptor I. J. Neuroimmunol. 56: 135-141.
10. Martin, D., S. L. Near, A. Bendele, and D. A. Russell. 1995. Inhibition of tumor necrosis factor is protective against neurologic dysfunction after active immunization of Lewis rats with myelin basic protein. Exp. Neurol. 131: 221-228.
11. Korner, H., D. S. Riminton, D. H. Strickland, F. A. Lemckert, J. D. Pollard, and J. D. Sedgwick. 1997. Critical points of tumor necrosis factor action in central nervous system autoimmune inflammation defined by gene targeting. J. Exp. Med. 186: 1585-1590.
12. Segal, B. M., B. K. Dwyer, and E. M. Shevach. 1998. An interleukin (IL)-10/IL-12 immunoregulatory circuit controls susceptibility to autoimmune disease. J. Exp. Med. 187: 537-546.
13. Khoury, S. J., W. W. Hancock, and H. L. Weiner. 1992. Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor β, interleukin 4, and prostaglandin E expression in the brain. J. Exp. Med. 176: 1355-1364.
14. Zavala, F., S. Abad, S. Ezine, V. Taupin, A. Masson, and J. F. Bach. 2002. G-CSF therapy of ongoing experimental allergic encephalomyelitis via chemokine- and cytokine-based immune deviation. J. Immunol. 168: 2011-2019.
15. + T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines. J. Exp. Med. 195: 603-616.
16. Confavreux, C., M. Hutchinson, M. M. Hours, P. Cortinovis-Tourniaire, T. Moreau, and the Pregnancy in Multiple Sclerosis Group. 1998. Rate of pregnancy-related relapse in multiple sclerosis. N. Engl. J. Med. 339: 285-291.
17. Whitacre, C. C. 2001. Sex differences in autoimmune disease. Nat. Immunol. 1: 777-780.
18. Ito, A., B. F. Bebo, Jr., A. Matejuk, A. Zamora, M. Silverman, A. Fyfe-Johnson, and H. Offner. 2001. Estrogen treatment down-regulates TNF-α production and reduces the severity of experimental autoimmune encephalomyelitis in cytokine knockout mice. J. Immunol. 167: 542-552.
19. + T cells and macrophages into the CNS of mice developing experimental encephalomyelitis. Clin. Immunol. 102: 275-282.
20. Youssef, S., O. Stuve, J. C. Patarroyo, P. J. Ruiz, J. L. Radosevich, E. M. Hur, M. Bravo, D. J. Mitchell, R. A. Sobel, L. Steinman, and S. S. Zamvil. 2002. The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease. Nature 420: 78-84.
21. Gonzalez, S., M. V. Alcaraz, J. Cuevas, M. Perez, P. Jaen, M. Alvarez-Mon, and V. G. Villarrubia. 2000. An extract of the fem Polypodium leucotomos (Difur) modulates Th1/Th2 cytokines balance in vitro and appears to exhibit antiangiogenic activities in vivo: pathogenic relationships and therapeutic implications. Anticancer Res. 20: 1567-1575.
22. Cos, P., T. De Bruyne, N. Hermans, S. Apers, D. V. Berghe, and A. J. Vlietinck. 2004. Proanthocyanidins in health care: current and new trends. Curr. Med. Chem. 11: 1345-1359.
23. Gali, H. U., E. M. Perchellet, X. M. Gao, J. J. Karchesy, and J. P. Perchellet. 1994. Comparison of the inhibitory effects of monomeric, dimeric, and trimeric procyanidins on the biochemical markers of skin tumor promotion in mouse epidermis in vivo. Planta Med. 60: 235-239.
24. Dauer, A., P. Metzner, and O. Schimmer. 1998. Proanthocyanidins from the bark of Hamamelis virginiana exhibit antimutagenic properties against nitroaromatic compounds. Planta Med. 64: 324-327.
25. Takahata, Y., M. Ohnishi-Kameyama, S. Furuta, M. Takahashi, and I. Suda. 2001. Highly polymerized procyanidins in brown soybean seed coat with a high radical-scavenging activity. J. Agric. Food Chem. 49: 5843-5847.
26. Chen, S., J. Gong, F. Liu, and U. Mohammed. 2000. Naturally occurring polyphenolic antioxidants modulate IgE-mediated mast cell activation. Immunology. 100: 471-480.
27. Mao, T. K., J. J. Powell, J. Van de Water, C. L. Keen, H. H. Schmitz, and M. E. Gershwin. 2000. Effect of cocoa procyanidins on the secretion of interleukin-4 in peripheral blood mononuclear cells. J. Med. Food. 3: 107-114.
28. Mao, T. K., J. Van de Water, C. L. Keen, H. H. Schmitz, and M. E. Gershwin. 2002. Effect of cocoa flavanols and their related oligomers on the secrelion of interleukin-5 in peripheral blood mononuclear cells. J. Med. Food 5: 17-22.
29. Mao, T. K., J. Van De Water, C. L. Keen, H. H. Schmitz, and M. E. Gershwin. 2000. Cocoa procyanidins and human cytokine transcription and secretion. J. Nutr. 130: 2093S-2099S.
30. Mao, T. K., J. Powell, J. Van de Water, C. L. Keen, H. H. Schmitz, J. F. Hammerstone, and M. E. Gershwin. 2000. The effect of cocoa procyanidins on the transcription and secretion of inlerleukin 1β in peripheral blood mononuclear cells. Life Sci. 66: 1377-1386.
31. Guyol, S., N. Marnet, D. Laraba, P. Sanoner and J. Drilleau. 1998. Reversed-phase HPLC following thiolysis for quantitative estimation and characterization of the four main classes of phenolic compounds in different tissue zones of a French cider apple variety (Malus domestica var. Kermerrien). J. Agric. Food Chem. 46: 1698-1705.
32. Guyot, S., N. Mamet, and J. Drilleau. 2001. Thiolysis-HPLC characterization of apple procyanidins covering a large range of polymerization states. J. Agric. Food Chem. 49: 14-20.
33. Saucier, C., M. Mirabel, F. Daviaud, A. Longieras, and Y. Glories. 2001. Rapid fractionation of grape seed proanthocyanidins. J. Agric. Food Chem. 49: 5732-5735.
34. Lazarus, S. A., G. E. Adamson, J. F. Hammerstone, and H. H. Schmitz. 1999. High-performance liquid chromatography/mass spectrometry analysis of proanthocyanidins in foods and beverages. J. Agric. Food Chem. 47: 3693-3701.
35. Tachibana, H., K. Koga, Y. Fujimura, and K. Yamada. 2004. A receplor for green lea polyphenol EGCG. Nat. Struct. Mol. Biol. 11: 380-381.