Design, synthesis and X-ray structure of protein-ligand complexes: Important insight into selectivity of memapsin 2 (β-secretase) inhibitors

Journal of the American Chemical Society

Volumn 128, Issue 16, 2006, Pages 5310-5311

  Ghosti, Arun K ^a   Kumaragurubaran, Nagaswamy ^a   Hong, Lin ^b,c   Lei, Hui ^b   Hussain, Khaja Azhar ^c   Liu, Chun Feng ^b   Devasamudram, Thippeswamy ^b   Weerasena, Vajira ^b   Turner, Robert ^b   Koelsch, Gerald ^b,c   Bilcer, Geoffrey ^b   Tang, Jordan ^c,d  

^a PURDUE UNIVERSITY   (United States)

^b Zapaq Inc   (United States)

^c UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

^d UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA SECRETASE INHIBITOR; LIGAND;

ARTICLE; CRYSTAL STRUCTURE; DRUG BINDING SITE; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SELECTIVITY; ENZYME ACTIVE SITE; HYDROPHOBICITY; LIGAND BINDING; OXIDATION; SAPONIFICATION;

AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; CHO CELLS; CRICETINAE; CRICETULUS; CRYSTALLOGRAPHY, X-RAY; LIGANDS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEASE INHIBITORS; PROTEINS;

EID: 33646452447     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja058636j     Document Type: Article

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