Impaired endothelium-dependent and neurogenic relaxation of corpus cavernosum from diabetic rats: Improvement with L-arginine

Urological Research

Volumn 28, Issue 1, 2000, Pages 14-19

  Gur S ^a   Ozturk B ^b   Karahan, S T ^a  

^a ANKARA UNIVERSITY   (Turkey)

^b Department of Urology   (Turkey)

Author keywords

Acetylcholine; Corpora cavernosa; Diabetes mellitus; L arginine

Indexed keywords

ACETYLCHOLINE; ARGININE; GLUCOSE; NITRIC OXIDE SYNTHASE; NITROPRUSSIDE SODIUM; PHENYLEPHRINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE DEHYDROGENASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORPUS CAVERNOSUM; DIABETES MELLITUS; ELECTROSTIMULATION; ENDOTHELIUM CELL; ERECTILE DYSFUNCTION; GLUCOSE BLOOD LEVEL; HISTOCHEMISTRY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE RELAXATION; SMOOTH MUSCLE TONE; STREPTOZOCIN DIABETES;

EID: 0343091526     PISSN: 03005623     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002400050003     Document Type: Article

References (22)

1. Ariëns EJ, Van Rossum JM (1957) pDx, pAx and pDx' values in analysis of pharmacodynamics. Arch Int Pharmacod Ther 110:275
2. Ariëns EJ, Simmonis AM (1964) Drug-receptor interaction of one or more drugs with a receptor system. In: Ariëns EJ (ed) Molecular Pharmacology. Academic Press, London 8:19
3. Azadzoi KM, Saenz de Tejada I (1992) Diabetes mellitus impairs neurogenic and endothelium dependent relaxation of rabbit corpus cavernosum smooth muscle. J Urol 146:1587
4. Bank N, Aynedjian HS (1993) Nitric oxide in diabetic renal hyperfiltration. Kidney Int 43:1306
5. Burnett AL (1997) Nitric oxide in the penis: physiology and pathology. J Urol 157:320
6. Dawson TM, Bredt DS, Foituhi M, Hwang PM, Synder SH (1991) Nitric oxide synthase and neuronal NADPH-Diaphorase are identical in brain and peripheral tissues. Proc Natl Acad Sci 88:7797
7. Elabaddy AA, Gagnon C, Hassouna MM, Begin LR, Elhilali MM (1995) Diabetes mellitus increases nitric oxide synthase in penises but not in major pelvic ganglia of rat. Br J Urol 76:196
8. Fosterman IJ, Closs EI, Pollock JS, Nakane M, Schwarz P, Gath I, Kleinert H (1994) Nitric oxide synthase isozymes. Characterization, purification, molecular cloning, and function. Hypertension 23:1121
9. Grill V, Bjorkman O, Gutniak M, Linqvist M (1992) Brain uptake and release of amino acids in nondiabetic and insulin dependent diabetic subjects: important role of glutamine release for nitrogen balance. Metabolism 41:28
10. Haas CA, Seftel AD, Razmjouei K, Ganz MB, Hampel N, Ferguson K (1998) Erectile dysfunction in aging: upregulation of endothelial ntiric oxide synthase. Urology 5:1516
11. Hagenfeldt L, Dahlquist G, Persson B (1989) Plasma amino acids in relation to metabolic control in insulin dependent diabetic children. Acta Pediatr Scand 794:278
12. Italiano G, Marin A, Pescatori ES, Calabro A, Artibani W, Pagano F, Triban C (1993) Effect of streptozotocin-induced diabetes on electrically evoked erection in the rat. Int J Impotence Res 5:27
13. Lowenstein CHJ, Dinerman CHJ, Synder SH (1994) Nitric oxide: a physiologic messenger. Ann Intern Med 120: 227
14. Mans AM, DeJoseph R, Dawis DW, Hawkins RA (1987) Regional amino acid transport into brain during diabetes: effect of plasma amino acids. Am J Physiol 253:E575
15. Pieper GM, Peltier BA (1995) Amelioration by L-arginine of a dysfunctional arginine/nitric oxide pathway in diabetic endothelium. J Cardiovasc Pharmacol 25:397
16. Saenz de Tejada I, Blanco R, Goldstein I, Azadzoi K, Morenas A, Krane RJ, Cohen RA (1988) Cholinergic neurotransmission in human corpus cavernosum. I. Responses of isolated tissue. Am J Physiol 254:H459
17. Saenz de Tejada IS, Goldstein I. Azadzoi K, Krane RJ, Cohen RA (1989) Impaired neurogenic and endothelium-mediated relaxation of penile smooth muscle from diabetic men with impotence. N Eng J Med 320:1025
18. Schirar A, Guiliano A, Rampin O, Rousseau JP (1994) A large proportion of pelvic neurons innervating the corpora cavernosa of the rat penis exhibit NADPH-diaphorase activity. Cell Tiss Res 278:517
19. Stief C, Benard F, Bosch R, Abosief S, Nunes L, Lue TF, Tanagho EA (1989) Acetylcholine as possible neurotransmitter in penile erection. J Urol 141:1444
20. Vanhatalo S, Klinge E, Sjostrand NO, Soinila S (1996) Nitric oxide synthesizing neurons originating at reversal different levels innervate rat penis. Neuroscience 75:891
21. dp (type II) rats with erectile dysfunction. Endocrinology 136:5709
22. Ward SM, Xue C, Shuttleworth CW, Bredt DS, Synder SH, Sanders KM (1992) NADPH-diaphorase and nitric oxide synthase colocalization in enteric neurons of canine proximal colon. Am J Physiol 263:G277