r-VKORC1 expression in factor IX BHK cells increases the extent of factor IX carboxylation but is limited by saturation of another carboxylation component or by a shift in the rate-limiting step

Biochemistry

Volumn 45, Issue 17, 2006, Pages 5587-5598

  Hallgren, Kevin W ^a   Qian, Wen ^a   Yakubenko, Anna V ^a   Runge, Kurt W ^a   Berkner, Kathleen L ^a  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; CARBOXYLATION; CELLS; CYTOLOGY; STOICHIOMETRY; VITAMINS;

MAMMALIAN CELLS; REDOX PROTEIN; VITAMIN K OXIDOREDUCTASE (VKOR); VITAMIN K-DEPENDENT (VKD) PROTEINS;

PROTEINS;

BLOOD CLOTTING FACTOR 9; CELL PROTEIN; DITHIOTHREITOL; OXIDOREDUCTASE; RECOMBINANT ENZYME; UNCLASSIFIED DRUG; VITAMIN K GROUP; VITAMIN K OXIDOREDUCTASE C1;

ANIMAL CELL; ARTICLE; CARBOXYLATION; CELL STRAIN BHK; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; IN VITRO STUDY; MAMMAL CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN METABOLISM; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION; STOICHIOMETRY;

ANIMALS; CARBON-CARBON LIGASES; CELL LINE; CRICETINAE; FACTOR IX; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; MIXED FUNCTION OXYGENASES; RECOMBINANT PROTEINS;

ANIMALIA; MAMMALIA;

EID: 33646370510     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi051986y     Document Type: Article

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