Identification of the vitamin K-dependent carboxylase active site: Cys-99 and Cys-450 are required for both epoxidation and carboxylation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 97, Issue 24, 2000, Pages 13033-13038

  Pudota, B Nirmala ^a   Miyagi, Masaru ^a   Hallgren, Kevin W ^a   West, Karen A ^a   Crabb, John W ^a   Misono, Kunio S ^a   Berkner, Kathleen L ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; CALCIUM; CARBON DIOXIDE; CYSTEINE; GLUTAMIC ACID; HYDROQUINONE; N ETHYLMALEIMIDE; SERINE; THIOL; VITAMIN K DEPENDENT CARBOXYLASE;

ARTICLE; CALCIUM HOMEOSTASIS; CARBOXYLATION; CATALYSIS; CELL GROWTH; COMPLEX FORMATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME SUBSTRATE COMPLEX; EPOXIDATION; HEMOSTASIS; HUMAN; MUTATION; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BINDING SITES; CARBON RADIOISOTOPES; CARBON-CARBON LIGASES; CYSTEINE; EPOXIDE HYDROLASES; ETHYLMALEIMIDE; HUMANS; KINETICS; PEPTIDE FRAGMENTS; PEPTIDE MAPPING; RECOMBINANT PROTEINS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TRYPSIN;

EID: 0034700163     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.97.24.13033     Document Type: Article

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