Vascular endothelial growth factor (VEGF) is present in human breast milk and its receptor is present on intestinal epithelial cells

Pediatric Research

Volumn 45, Issue 5, 1999, Pages 652-657

  Siafakas, Constantinos G ^a   Anatolitou, Fani ^b   Fusunyan, Robert D ^a   Walker, W Allan ^a   Sanderson, Ian R ^a,c  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b AGHIA SOPHIA CHILDREN S HOSPITAL   (Greece)

^c QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

VASCULOTROPIN; VASCULOTROPIN RECEPTOR;

ARTICLE; BREAST FEEDING; BREAST MILK; CELL PROLIFERATION; CELL STRAIN CACO 2; CONTROLLED STUDY; GESTATIONAL AGE; HUMAN; HUMAN CELL; INTESTINE EPITHELIUM CELL; MILK LEVEL; PRIORITY JOURNAL; PROTEIN DETERMINATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADULT; BINDING, COMPETITIVE; ENDOTHELIAL GROWTH FACTORS; FEMALE; HUMANS; INFANT, NEWBORN; INFANT, PREMATURE; INTESTINAL MUCOSA; IODINE RADIOISOTOPES; KINETICS; LACTATION; LYMPHOKINES; MILK, HUMAN; RADIOLIGAND ASSAY; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, GROWTH FACTOR; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; REFERENCE VALUES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TIME FACTORS; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0032955187     PISSN: 00313998     EISSN: 15300447     Source Type: Journal    
DOI: 10.1203/00006450-199905010-00007     Document Type: Article

References (23)

1. Keck PJ, Mounth SD, Krivi G, Sanzo K, Warren T, Feder J, Connoly DT 1989 Vascular permeability factor, an endothelial cell mitogen related to PDGF. Science 246:1309-1312
2. Connolly DT, Heuvelman DM, Nelson R, Olander JV, Eppley BL, Delfino JJ, Siegel NR, Leimgruber RM, Feder J 1989 Tumor vascular permeability factor stimulates endothelial cell growth and angiogenesis. J Clin Invest 84:1470-1478
3. Soker S, Fidder H, Neufeld G, Klagsburn M 1996 Characterization of novel vascular endothelial growth factor (VEGF) receptors on tumor cells that bind VEGF165 via its exon 7-encoded domain. J Biol Chem 271:5761-5767
4. Brown LF, Detmar M, Claffley K, Nagy JA, Feng D, Dvorak AM, Dvorak HF 1997 Vascular endothelial growth factor/vascular permeability: a multifunctional angiogenic cytokine. EXS 79:233-269
5. Senger DR, Van De Water L, Brown LF, Nagy JA, Yeo TK, Berse B, Jackman RW, Dvorak AM, Dvorak HF 1993 Vascular endothelial growth factor (VPF, VEGF) in tumor biology. Cancer Metastasis Rev 12:303-324
6. Soker S, Takashima S, Miao HQ, Neufeld G, Klagsbrun M 1998 Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor. Cell 92:735-745
7. Xanthou M, Bines J, Walker WA 1995 Breast milk and intestinal host defense in newborns: an update. Adv Pediatr 42:171-208
8. Lucas A, Cole TJ 1990 Breast milk and neonatal necrotising enterocolitis. Lancet 336:1519-1523
9. Goldman AS 1993 The immune system of human milk, antimicrobial, anti-inflammatory, and immunomodulating properties. Pediatr Infect Dis J 12:664-672
10. Pinto M, Robine-Leon S, Appay MD, Kedinger M, Triadou N, Dussaulx E, Lacroix B, Simon-Assman P, Haffen K, Fogh J, Zweibaum A 1983 Enterocyte-like differentiation and polarization of the human colon carcinoma cell line Caco-2 in culture. Biol Cell 47:323-330
11. Oguchi S, Walker WA, Sanderson IR 1995 Differentiation and polarity alter the binding of IGF-I to human intestinal epithelial (Caco-2) cells. J Pediatr Gastroenterol Nutr 20:148-155
12. Sanderson IR, Ezzell RM, Kedinger M, Erlanger M, Xu ZX, Pringault E, Robine SL, Louvard D, Walker WA 1996 Human fetal enterocytes in vitro; modulation of the phenotype by extracellular matrix. Proc Natl Acad Sci USA 93:7717-7722
13. Akiyoshi F, Sata M, Suzuki H, Uchimura K, Mitsuyama K, Matsuo K, Tanikawa K 1998 Serum vascular endothelial growth factor levels in various liver diseases. Dig Dis Sci 43:41-45
14. Sanderson IR, Ouellette AJ, Carter EA, Harmatz PR 1993 Ontogeny of Ia messenger RNA in the mouse intestinal epithelium is modulated by age of weaning and diet. Gastroenterology 105:974-980
15. Brown LF, Berse B, Jackman RW, Tognazzi K, Manseau EJ, Senger DR, Dvorak HF 1993 Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in adenocarcinomas of the gastrointestinal tract. Clin Cancer Res 53:4727-4735
16. Yamamoto Y, Kondo S, Matsumoto T, Suzuki H, Kitamura M, Tsuruta K, Taniguchi T, Okamoto A, Mori T, Yoshida M, Ikeda T, Tominaga T 1996 Concentrations of vascular endothelial growth factor in the sera of normal controls and cancer patients. Clin Cancer Res 2:821-826
17. Cullinan-Bore K, Koos R 1993 Vascular endothelial growth factor/vascular permeability factor expression in the rat uterus: rapid stimulation by estrogen correlates with estrogen-induced increases in uterine capillary permeability and growth. Endocrinology 133:829-837
18. Waltenberger J, Claesson-Welsh L, Siegbahn A, Shibuya M, Heldin CH 1994 Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor. J Biol Chem 269:26988-26995
19. Smithson KW, Millar DB, Jacobs LR, Gray GM 1981 Intestinal diffusion barrier; unstirred layer or membrane surface mucous coat? Science 214:1241-1244
20. Magnusson KE, Stjernstrom I 1982 Mucosal barrier mechanisms. Interplay between secretory IgA (sIgA), IgG, and mucins on the surface properties and association of salmonellae with intestine and granulocytes. Immunology 45:239-248
21. Said HM, Smith R, Redha R 1987 Studies in the intestinal surface acid microclimate: developmental aspects. Pediatr Res 22:497-499
22. Sioussat TM, Dvorak HF, Brock TA, Senger DR 1993 Inhibition of vascular permeability factor (vascular endothelial growth factor) with antipeptide antibodies. Arch Biochem Biophys 301:15-20
23. Connolly DT 1991 Vascular permeability factor is a unique regulator of blood vessel function. J Cell Biochem 47:219-223