Bovine milk inhibits proteolytic degradation of epidermal growth factor in human gastric and duodenal lumen

Peptides

Volumn 19, Issue 3, 1998, Pages 495-504

  Rao, R K ^a   Baker, R D ^a   Baker, S S ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Digestion; Duodenum; EGF; Peptidase inhibitor; Peptide; Protease; Stomach

Indexed keywords

PROTEINASE INHIBITOR; RECOMBINANT EPIDERMAL GROWTH FACTOR; SOYBEAN TRYPSIN INHIBITOR; TRYPSIN INHIBITOR;

ARTICLE; CONTROLLED STUDY; DIET; DIGESTION; DOSE RESPONSE; DUODENUM; HUMAN; MILK; PRIORITY JOURNAL; PROTEIN DEGRADATION; RADIOACTIVITY; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; STOMACH;

ADOLESCENT; ANIMALS; DIETARY PROTEINS; DUODENUM; EPIDERMAL GROWTH FACTOR; HUMANS; MILK; MILK PROTEINS; PROTEASE INHIBITORS; STOMACH;

EID: 0031900116     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0196-9781(97)00462-2     Document Type: Article

References (29)

1. Bockus, H. L. In: Bochus, H. L.; ed. Gastroenterology Vol. 1. Philadelphia: WB Saunders; 1974:680-684.
2. Britton J. R., George-Nascimento C., Koldovsky O. Luminal hydrolysis of recombinant human epidermal growth factor in the rat gastrointestinal tract segmental and developmental differences . Life Sci. 43:1988;1339-1347.
3. Britton J. R., George-Nascimento C., Udall J. N., Koldovsky O. Minimal hydrolysis of epidermal growth factor by gastric fluid of preterm infants. Gut. 30:1989;327-332.
4. Carlsson L. C. T., Westrom B. R., Karlsson B. W. Intestinal absorption of proteins by the neonatal piglet fed on cow's colostrum with either natural or experimentally eliminated trypsin-inhibiting activity. Biol. Neonate. 38:1980;309-320.
5. Gray M. R., Donnelly R. J., Kingsnorth A. N. Role of salivary epidermal growth factor in the pathogenesis of Barrett's columnar lined oesophagus. Br. J. Surg. 78:1991;1461-1466.
6. Howarth G. S., Francis G. L., Cool J. C., Xu X., Byard R. W., Read L. C. Milk growth factors enriched from cheese whey ameliorates intestinal damage by methotrexate when administered orally to rats. J. Nutr. 126:1996;2519-2530.
7. Kayasseh L., Gyr K., Keller U., Stadler G. A., Wall M. Somatostatin and cimetidine in peptic-ulcer hemorrhage A randomized controlled trial . Lancet. 1:1980;844-846.
8. Kelly S. M., Crampton J., Hunter J. O. Decreased salivary epidermal growth factor in rheumatoid disease a possible mechanism for increased susceptibility to gastric ulceration . Br. Med. J. 301:1990;422-423.
9. Koldovsky O., Bedrick A., Pollack P., Rao R. K., Thornburg W. Hormones in milk, their presence and possible physiological significance. Goldman A. S., Atkinson A., Hanson L. A. Effects of human milk on the recipient infant. 1987;183-196 Plenum Press, New York.
10. Konturek J. W., Brzozowski T., Konturek S. J. Epidermal growth factor in protection, repair, and healing of gastroduodenal mucosa. J. Clin. Gastroenterol. 13:1991;s88-s97.
11. Lindberg T. Protease inhibitors in human milk. Pediat. Res. 13:1979;969-972.
12. Lucas A., Cole T. J. Breast milk and neonatal necrotizing enterocolitis. Lancet. 336:1990;1519-1525.
13. Ohmura E., Emoto N., Tsushima T., Watanabe S., Takeuchi T., Kawamura M., Shigemoto M., Shizume K. Salivary immunoreactive human epidermal growth factor (IR-EGF) in patients with peptic ulcer disease. Hepatogastroenterology. 34:1987;160-163.
14. Philipps A. F., Rao R. K., Anderson G. G., McCracken D. M., Lake M., Koldovsky O. Fate of insulin-like growth factors I and II administered orogastrically to suckling rats. Pediatr. Res. 37:1995;586-592.
15. Playford R. J., Woodman A. C., Clark P., Watanapa P., Vesey D., Deprez P. H., Williamson R. C., Calam J. Effect of luminal growth factor preservation on intestinal growth. Lancet. 341:1993;843-848.
16. Playford R. J., Marchbank T., Calnan D. P., Poyston P., Batten J. J., Hansen H. F. Epidermal growth factor is digested to smaller, less active forms in acidic gastric juice. Gastroenterology. 108:1995;92-101.
17. 125I-epidermal growth factor in developing rat jejunum and ileum. Peptides. 11:1990;1093-1102.
18. Rao R. K., Koldovsky O., Davis T. P. Inhibition of intestinal degradation of somatostatin by rat milk. Am. J. Physiol. 258:1990;G426-G431.
19. Rao R. K. Biologically active peptides in the gastrointestinal lumen. Life Sci. 48:1991;1685-1704.
20. Rao R. K., Koldovsky O., Grimes J., Williams C., Davis T. P. Regional differences in the gastrointestinal processing and absorption of epidermal growth factor in suckling rats. Am. J. Physiol. 261:1991;G790-G798.
21. Rao R. K., Lam K., Philipps A. F., Williams C., Lake M., Koldovsky O. Presence of multiple forms of peptidase inhibitors in rat milk. J. Pediatr. Gastroenterol. Nutr. 17:1993;414-420.
22. Rao R. K., Sherman P., Hillel N., McKilligan V., Thomas D. W. Lower levels of epidermal growth factor in saliva from patients with Crohn's Disease and Ulcerative Colitis. Gastroenterology. 106:1994;A758.
23. Rao R. K. Luminal processing of epidermal growth factor in mouse gastrointestinal tract in vivo. Peptides. 16:1995;505-513.
24. Rao R. K., Koldovsky O., Davis T. P. Metabolism of somatostatin in the rat duodenal lumen. Peptides. 16:1995;505-513.
25. Rao R. K., Thomas D. W., Pepperl S., Porreca F. Salivary epidermal growth factor plays a role in the protection of ileal mucosal integrity. Dig. Dis. Sci. 42:1997;2175-2181.
26. Schrumpf E., Vatn M. H., Hanssen K. F., Semb S., Myren J. Somatostatin inhibits insulin-stimulated gastrin release and gastric secretion of acid, pepsin, and intrinsic factor (IF) in duodenal ulcer patients. Scand. J. Gastroenterol. 11:1976;517-520.
27. Veselsky L., Cechova D., Jonakova V. Secretion and immunochemical properties of the trypsin inhibitor from bovine colostrum. Hoppe-Seyler's Z. Physiol. Chem. 359:1978;873-878.
28. Watson L. C., Abston S. Prevention of upper gastrointestinal hemmorhage in 582 burned children. Am. J. Surg. 132:1976;790-793.
29. Westrom B. R., Carlsson L. C. T. Trypsin inhibitors in serum of adult and suckling rats and rat milk. Int. J. Biochem. 7:1976;41-47.