Studies on some biologically active substituted 4(3H)-quinazolinones. Part 1. Synthesis, characterization and anti-inflammatory#-antimicrobial activity$ of 6,8-disubstituted 2-phenyl-3-[substituted-benzothiazol-2-yl]-4(3H)-quinazolinones

Arkivoc

Volumn 2006, Issue 11, 2006, Pages 1-20

  Laddha, Sachin S ^a   Wadodkar, Sudhir G ^a   Meghal, Sharad K ^a  

^a RTM NAGPUR UNIVERSITY   (India)

Author keywords

2 Phenyl 3 substituted benzothiazol 2 yl 4(3H) quinazolinone; 2 phenyl 3 substituted benzothiazol 2 yl 4(3H) quinazolinone; 6,8 dibromo; Anti inflammatory; Antimicrobials; COX 1 and 2 inhibitory activity

Indexed keywords

EID: 33646247872     PISSN: 14246376     EISSN: 14246376     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. Allison, M.C.; Howatson, A.G.; Torrance, C.J.; Lee, F.D., Russell, R.I N.Engl. J. Medi. 1992, 327, 749.
2. Vane, J.R. Nat.New.Biol. 1971, 231, 232.
3. Amadio, P.; Cummings, D.M. Prosgrad. Med. 1993, 93,73.
4. Wallace, J.L.; Carter, E.; Mcknight, G.W.; Le, T.; McCafferty, D.M.; Aregentierh, D.; Capetola, R. Gastroenterology 1993, 104,(A), 221.
5. th Edn., Lemke, T.L.; Williams, D.A., Eds., International student edn., Lippincott, Williams and Wilkins, 2002, pp 751-793.
6. Song, Y.; Connor, D.T. ; Sercel, A.D. ; Sorenson, R.J. ; Doubleday. R.; Unangst, P.C.; Roth. B.D.; Beylin, V.G. ; Gilbertsen, R.B. ; Chan, K. ; Schrier, D.J.; Guglietta, A.; Bornemeier, D.A.; Dyer, R.D. J.Med.Chem.1999,42, 1161.
7. Puig, C. ; Crespo, M.I.; Godessart, N.; Feixas, J.; Iharzo, J.; Jimenez, J.M.; Soca, L.; Cardelus, I.; Heredia, A.; Miralpeix, M.; Puig, J.; Beleta, J.; Huerta, J.M.; Lopez, M.; Segarra, V.; Ryder H.; Palacios, J.M. J.Med.Chem. 2000, 43, 214.
8. Vane, J.R.; Bakhle, Y.S.; Botting, R.M. Annu. Rev. Pharmacol. Toxicol. 1998, 38, 97.
9. Fu, J-Y.; Maferrer, J.L.; Seibert, K.; Raj, A.; Needleman, P. J.Biol. Chem. 1990, 265,16737.
10. Mitchell, J.A.; Akarasereenont, P.; Thiemermann, C.; Flower, R.J.; Vane, J.R. Proc. Natl. Acad. Sci. USA. 1993, 90, 11693
11. Smith, W.L.; Garavito, M.; DeWitt, D.L. J. Biol. Chem. 1996, 271, 33157
12. Gerd, D.; Werner, K. E. J. Med. Chem. 2001, 36, 109
13. Giuseppe, C.; Vincenzo, S.; Elisa, P.; Beatrice, S.; Ferdinando, F.; Timothy, D.W.; John, L.W.; Demian, R.I.; Edson, A.; Giuseppe, C.; Gilberto, De. N. Eur. J. Med. Chem. 2001, 36, 517.
14. Wolfe, J.F.; Rathman, T.L.; Sleevi, M.C.; Campbell, J.A.; Greenwood, T.D. J. Med. Chem. 1990, 33, 161.
15. Rastogi, V.K.; Parmar, S.S.; Sing, S.P.; Akers, T.K. J. Heterocycl. Chem. 1978, 15, 497.
16. Rao A.R.R.; Bahekar, R.H. Ind. J. Chem. 38B 1999, 4, 434
17. Bahekar, R.H.; Rao A.R.R. Arzneim.-Forsch./Drug Res. 2001, 51, 284.
18. Bansal, E.; Ram, T.; Sharma, S.; Tyagi, M.; Preeti Rani, A.; Bajaj, K.; Tyagi, R.; Goel, B.; Srivastava, V.K.; Guru, J.N.; Kumar, A. Ind. J. Chem. 2001, 40B, 307.
19. Okumura, K., Oine, T., Yamada,Y., Hayashi, G., Nakama, M., Nose, T. J. Med. Chem. 1968, 11, 788.
20. Ozaki, K.; Yamada, Y.; Oine, T., Ishizuka, T.; Iwasawa, Y. J.Med.Chem. 1985, 28, 568.
21. Bhargava, P.N.; Chaurasia, M.R. J.Med.Chem. 1968, 11, 404.
22. Parmar, S.S.; Kumar, R. J.Med.Chem. 1968, 11, 635.
23. Alagarsamy, V.; Pathak, V.S.; Venkateshperumul, R.; Meena, S.; Thirumurugan, K.; Solomon, R.; Declercq, E. Indian. J. Pharm. Sci. 2003, 65, 293.
24. Antonini, I.; Cristalli, G.; Franchetti, P.; Grifantini, M.; Martelli, S. J. Heterocyclic. Chem. 1980, 17, 155.
25. Skibo, E.B.; Huang, X.; Martinez, R.; Lemus, R.H.; Craigo, W.A.; Dorr, R.T. J.Med.Chem. 2002, 45, 5543.
26. Pandey, A.; Volkots, D.L.; Seroogy, J.M.; Rose, J.W.; Yu Jin-chen, Lambing, J.L.; Hutchaleelaha, A.; Hollenbach, S.J.; Abe, K.; Giese, N.A.; Scarborough, R.M. J. Med. Chem. 2002, 45, 3772.
27. Webb, T.R.; Lvovskiy, D.; Kim, S.; Xiago-duo, Ji.; Melman, N.; Linden, J.; Jacobson, K.A. J. Biorg. Med. Chem. 2003, 2, 77.
28. Pannerselvam, P.; Pradeepchandran, R.V.; Sridhar, S.K. Indian J. Pharm. Sci. 2003, 65, 268.
29. Beneteau, V.B.T.; Guillard, J.; Leance, S.M.; Pfeiffer, B. Eur. J. Med. Chem. 1999, 34, 1053.
30. Kabeer, A.S.; Baseer, M.A.; Mote, N.A. Asian J. Chem. 2001, 13, 496.
31. Hassan, K.H.M.; Mahmoud, A.M.; El-Sherief, A. Z. Naturforsch IV. 1978, 33B, 1005.
32. Nadkarni, A.B.; Kamath, R.V.; Khadse, G.B.; Indian J. Heterocycl. Chem. 2000, 9, 309
33. Mruthyunjayasawmy, B.H.M.; Shanthaveerappa, B.K. Indian J. Chem. Sec-B 2000, 39, 433.
34. Miyamatsn, H.; Ueno, S.; Shimizu, M.; Hosono, J.; Tomari, M.; Seida, K.; Suzuki, T.; Wada, J. J. Med. Chem. 1974, 17, 491.
35. Hays, J.S.; Rice, M.J.; Ortwine, D.F.; Johnson, G.; Schwarz, R.D.; Boyd, D.K.; Copceland, F.L.; Vartanian, M.J.; Boxer, P.A . J.Pharm. Sci. 1994, 833, 1425.
36. Chopade, R.S.; Bahekar, R.H.; Khedekar, P.B.; Bhusari, K.P.; Rao, A.R.R. Arch. Pharm. 2002, 8, 381.
37. Rose, U J. Heterocyclic Chem., 1992, 29, 551.
38. Gineinath, M.M.; El-Sherbeny A.E.I.; Nasr, M.N.; Maarouf, A.R. Arch. Pharm. Med. Chem. 2002, 11, 556.
39. Winter, C.A.; Edwin, A.R.; Nuss, G.W. Proc. Soc. Exp. Biol. Med. III. 1962, 544.
40. Wakitani, T.; Nanayama, M.; Masaki, M.; Matsushita, Jpn. J. Pharmacol. 1998, 78, 365.
41. Sancilio, L.F.; Nolan, J.C.; Wagner, L.E. Arzneim.-Forsch./Drug Res. 1987, 37, 513.
42. Trefouel, J.; Trefouel, M.; Nitti, F.; Bovet, D. Chem. Res. Soc. Bio. 1935, 120, 756.
43. Zentmyr, D.T.; Wagner, E.C. J. Org. Chem. 1949, 14, 967.