Homocysteine induces production of monocyte chemoattractant protein-1 and interleukin-8 in cultured human whole blood

Acta Pharmacologica Sinica

Volumn 25, Issue 11, 2004, Pages 1419-1425

  Zeng, Xiao Kun ^a   Remick, Daniel G ^d   Wang, Xian ^a,b,c  

^a PEKING UNIVERSITY THIRD HOSPITAL   (China)

^b Beijing Medical College   (China)

^c PEKING UNIVERSITY   (China)

^d UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Atherosclerosis; Homocysteine; Interleukin 8; Monocyte chemoattractant protein 1; Monocytes

Indexed keywords

ALPHA CHEMOKINE; HOMOCYSTEINE; HYDROXYL RADICAL; INTERLEUKIN 8; MONOCYTE CHEMOTACTIC PROTEIN 1;

AMINO ACID BLOOD LEVEL; AMINO ACID METABOLISM; ARTICLE; ATHEROSCLEROSIS; BLOOD CULTURE; BLOOD SAMPLING; CARDIOVASCULAR DISEASE; ENDOTHELIUM CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; HYPERHOMOCYSTEINEMIA; OXIDATIVE STRESS; RECEPTOR UPREGULATION;

CELLS, CULTURED; CHEMOKINE CCL2; HOMOCYSTEINE; HUMANS; INTERLEUKIN-8; L-LACTATE DEHYDROGENASE; MONOCYTES; PEROXIDASE; REACTIVE OXYGEN SPECIES;

EID: 8644239394     PISSN: 16714083     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Malinow MR, Nieto FJ, Szklo M, Chambless LE, Bond G. Carotid artery intimal-medial wall thickening and plasma homocyst(e)ine in asymptomatic adults. The atherosclerosis risk in communities study. Circulation 1993; 87: 1107-13.
2. Clarke R, Daly L, Robinson K, Naughten E, Cahalane S, Fowler B, et al. Hyperhomocysteinemia: an independent risk factor for vascular disease. N Engl J Med 1991; 324: 1149-55.
3. Robinson EA, Yoshimura T, Leonard EJ, Tanaka S, Griffen PR, Shabanowitz J, et al. Complete amino acid sequence of a human monocyte chemoattractant, a putative mediator of cellular immune reaction. Proc Natl Acad Sci USA 1989; 86: 1850-4.
4. Baggiolini M, Walz A, Kunkel SL. Neutrophil-activating peptide-1/interleukin 8, a novel cytokine that attracts neutrophils. J Clin Invest 1989; 84: 1045-9.
5. Reape TJ, Groot P. Chemokines and atherosclerosis. Atherosclerosis 1999; 147: 213-6.
6. de Lemos JA, Morrow DA, Sabatine MS, Murphy SA, Gibson CM, Antman EM, et al. Association between plasma levels of monocyte chemoattractant protein-1 and long-term clinical outcomes in patients with acute coronary syndromes. Circulation 2003; 107: 690-5.
7. Romuk E, Skrzep-Poloczek B, Wojciechowska C, Tomasik A, Birkner E, Wodniecki J, et al. Selectin-P and interleukin-8 plasma levels in coronary heart disease patients. Eur J Clin Invest 2002; 32: 657-61.
8. Van Aken BE, den Heijer M, Bos GM, van Deventer SJ, Reitsma PH. Recurrent venous thrombosis and markers of inflammation. Thromb Haemost 2000; 83: 536-9.
9. Van Aken BE, Reitsma PH, Rosendaal FR. Interleukin 8 and venous thrombosis: evidence for a role of inflammation in thrombosis. Br J Haematol 2002; 116: 173-7.
10. Poddar R, Sivasubramanian N, DiBello PM, Robinson K, Jacobsen DW. Homocysteine induces expression and secretion of monocyte chemoattractant protein-1 and interleukin-8 in human aortic endothelial cells. Circulation 2001; 103: 2717-30.
11. Sung FL, Slow YL, Wang G, Lynn EG, OK. Homocysteine stimulates the expression of monocyte chemoattractant protein-1 in endothelial cells leading to enhanced monocyte chemotaxis. Mol Cell Biochem 2001; 216: 121-8.
12. Wang G, Siow YL, O K. Homocysteine stimulates nuclear factor kappaB activity and monocyte chemoattractant protein-1 expression in vascular smooth-muscle cells: a possible role for protein kinase C. Biochem J 2000; 352: 817-26.
13. DeForge LE, Kenney JS, Jones ML, Warren JS, Remick DG. Biphasic production of IL-8 in lipopolysaccharide (LPS)-stimulated human whole blood. Separation of LPS- and cytokine-stimulated components using anti-tumor necrosis factor and anti-lL-1 antibodies. J Immunol 1992; 148: 2133-41.
14. DeForge LE, Fantone JC, Kenney JS, Remick DG. Oxygen radical scavengers selectively inhibit interleukin 8 production in human whole blood. J Clin Invest 1992; 90: 2123-9.
15. Beckman JS, Minor RL Jr, White CW, Repine JE, Rosen GM, Freeman BA. Superoxide dismutase and catalase conjugated to polyethylene glycol increases endothelial enzyme activity and oxidant resistance. J Biol Chem 1988; 263: 6884-92.
16. Wang G, Woo CW, Sung FL, Siow YL, O K. Increased monocyte adhesion to aortic endothelium in rats with hyperhomocysteinemia: role of chemokine and adhesion molecules. Arterioscler Thromb Vasc Biol 2002; 22: 1777-83.
17. Gerszten RE, Garcia-Zepeda EA, Lim YC, Yoshida M, Ding HA, Gimbrone MA Jr, et al. MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions. Nature 1999; 398: 718-23.
18. Mudd SH, Skovby FS, Levy HL, Pettigrew KD, Wilcken B, Pyeritz RE, et al. The natural history of homocystinuria due to cystathione β-synthase deficiency. Am J Hum Genet 1985; 37: 1-31.
19. Selhub J, D'Angelo A. Hyperhomocysteinemia and thrombosis: acquired conditions. Thromb Haemost 1997; 78: 527-31.
20. Woo KS, Chook P, Lolin YI, Cheung AS, Chan LT, Sun YY, et al. Homocyst(e)inemia is a risk factor arterial endothelial dysfunction in human. Circulation 1997; 96: 2542-4.
21. Haynes WG. Hyperhomocysteinemia, vascular function and atherosclerosis: effects of vitamins. Cardiovasc Drugs Ther 2002; 16: 391-9.
22. Stampfer MJ, Malinow MR, Willett WC, Newcomer LM, Upson B, Ullmann D, et al. A prospective study of plasma homocysteine and risk of myocardial infarction in US physicians. J Am Med Assoc 1992; 268: 877-81.
23. Harker LA, Slichter SJ, Scott CR, Ross R. Homocysteinemia: vascular injury and aterial thrombosis. N Engl J Med 1974; 291: 537-43.
24. Refsum H, Ueland PM. Recent data are not in conflict with homocysteine as a cardiovascular risk factor. Curr Opin Lipidol 1998; 9: 533-9.
25. Nygard O, Nordrehaug JE, Refsum H, Ueland PM, Farstad M, Vollset SE. Plasma homocysteine levels and mortality in patients with coronary artery disease. N Engl J Med 1997; 337: 230-6.
26. Nelken NA, Coughlin SR, Gordon D, Wilcox JN. Monocyte chemoattractant protein-1 in human atheromatous plaques. J Clin Invest 1991; 88: 1121-7.
27. Ylä-Herttuala S, Lipton BA, Rosenfeld ME, Särkioja T, Yoshimura T, Leonard EJ, et al. Expression of monocyte chemoattractant protein-1 in macrophage-rich areas of human and rabbit atherosclerotic lesions. Proc Natl Acad Sci USA 1991; 88: 5252-6.
28. Takeya M, Yoshimura T, Leonard EJ, Takahashi K. Detection of monocyte chemoattractant protein-1 in human atherosclerotic lesions by an anti-monocyte chemoattractant protein-1 monoclonal antibody. Human Pathol 1993; 24: 539-43.
29. Apostolopoulos J, Davenport P, Tipping PG. Interleukin-8 production by macrophages from atheromatous plaques. Arterioscler Thromb Vasc Biol 1996; 16: 1007-12.
30. Zhang Q, Zeng X, Guo J, Wang X. Effects of homocysteine on murine splenic B lymphocyte proliferation and its signal transduction mechanism. Cardiovasc Res 2001; 52: 328-36.
31. Zhang Q, Zeng X, Guo J, Wang X. Oxidant stress mechanism of homocysteine potentiating Con A-induced proliferation in murine splenic T lymphocytes. Cardiovasc Res 2002; 53: 1035-42.
32. Weiss N, Heydrick S, Zhang YY, Bierl C, Cap A, Loscalzo J. Cellular redox state and endothelial dysfunction in mildly hyperhomocysteinemic cystathionine beta-synthase-deficient mice. Arterioscler Thromb Vasc Biol 2002; 22: 34-41.
33. Zeng X, Dai J, Remick DG, Wang X. Homocysteine mediated expression and secretion of monocyte chemoattractant protein-1 and interleukin-8 in human monocytes. Circ Res 2003; 93: 311-20.
34. Heinecke JW, Rosen H, Suzuki LA, Chait A. The role of sulfur-containing amino acids in superoxide production and modification of low-density lipoprotein by arterial smooth muscle cells. J Biol Chem 1987; 262: 10098-103.
35. Brandes RP, Viedt C, Nguyen K, Beer S, Kreuzer J, Busse R, et al. Thrombin-induced MCP-1 expression involves activation of the p22phox-containing NADPH oxidase in human vascular smooth muscle cells. Thromb Haemost 2001; 85: 1104-10.
36. Roebuck KA. Oxidant stress regulation of IL-8 and ICAM-1 gene expression: differential activation and binding of the transcription factors AP-1 and NF-kappaB (Review). Int J Mol Med 1999; 4: 223-30.
37. Baldus S, Heeschen C, Meinertz T, Zeiher AM, Eiserich JP, Munzel T, et al. CAPTURE Investigators: myeloperoxidase serum levels predict risk in patients with acute coronary syndromes. Circulation 2003; 23: 1440-5.
38. Re G, Lanzarini C, Vaona I, Pazzaglia M, Palareti G, Bassein L, et al. Systemically circulating oxidative species in human deep venous thrombosis. Eur J Emerg Med 1998; 5: 9-12.
39. Kasahara T, Mukaida N, Yamashita K, Yagisawa H, Akahoshi T, Matsushima K. IL-1 and TNF-alpha induction of IL-8 and monocyte chemotactic and activating factor (MCAF) mRNA expression in a human astrocytoma cell line. Immunology 1999; 74: 60-7.