Ghrelin - The guardian of energy balance;Grelina - Strażnik równowagi energetycznej

Psychiatria Polska

Volumn 40, Issue 1, 2006, Pages 119-128

  Janas Kozik, Małgorzata ^a,b   Krupka Matuszczyk, Irena ^a   Tomasik Krótki, Jagna ^c  

^a Katedra i Klinika Psychiatrii i Psychoterapii   (Poland)

^b AM   (Poland)

^c Gornoslaskiego Centrum Zdrowia Dziecka i Matki w Katowicach   (Poland)

Author keywords

Eating disorders; Energy balance; Ghrelin

Indexed keywords

GHRELIN; GROWTH HORMONE; HYDROCHLORIC ACID; HUMAN GROWTH HORMONE; PEPTIDE HORMONE;

ANOREXIA NERVOSA; ARTICLE; BULIMIA; DIGESTIVE SYSTEM; EATING DISORDER; ENERGY BALANCE; FEEDING; FEEDING BEHAVIOR; FOOD INTAKE; GROWTH HORMONE RELEASE; HORMONE ACTION; HUMAN; MALNUTRITION; METABOLISM; NUTRITION; PANCREAS FUNCTION; STOMACH; STOMACH ACID SECRETION; ANIMAL; DIGESTION; EATING; ENERGY METABOLISM; GASTROINTESTINAL TRACT; NEUROSECRETION; PHYSIOLOGY; REVIEW; SECRETION;

ANIMALS; APPETITE REGULATION; DIGESTION; EATING; ENERGY METABOLISM; GASTROINTESTINAL TRACT; HUMAN GROWTH HORMONE; HUMANS; NEUROSECRETORY SYSTEMS; PEPTIDE HORMONES;

EID: 33646237790     PISSN: 00332674     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (44)

1. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. Ghrelin is a growth-hormone-releasing acylatedpeptide from stomach. Nature 1996; 402: 656-660.
2. Łazarczyk M, Łazarczyk M, Grzela T. Ghrelin: A recently discovered gut-brain peptide. Int. J. Molec. Med. 2003; 12: 279-287.
3. Hosoda H, Kojima M, Mizushima T, Shimizu S, Kangawa K. Structural divergence of human ghrelin. Identification of multiple ghrelin-derived molecules produced by post-translational processing. J. Biol. Chem. 2003; 278: 64-70.
4. Wu J, Kral J. Ghrelin, integrative neuroendocrine peptide in health and disease. Ann. Surg. 2004; 239: 464-474.
5. Smith RG, Palyha OC, Feighner SD i in. Growth hormone realising substances: types and thir receptors. Horm. Res. 1999; 51: 1-8.
6. Howard AD, Feighner SD, Cully DF i in. A receptor in pituitary and hypothalamus that functions in growth hormone release. Science 1996; 273: 974-977.
7. Kojima M, Hosoda H, Matusuo H i in. Ghrelin: discovery of the natural endogenous ligand for the growth hormone secretagogue receptor. Trends Endocr. Metab. 2001; 12: 118-121.
8. Casanueva FF, Diaguez C. Growth hormone secretagogues: phisiological role and clinical utility. Trends Endocrin. Metab. 1999; 10: 30-38.
9. Bellone A, Rapa A, Vivenza D, Vercellotti A, Petri A, Radetti G, Bellone J, Broglio F, Ghigo E, Bona G. Circulating ghrelin levels in newborns are not associated to gender, body weight and hormonal parameters but depend on the type of delivery. J. Endocrinol. Invest. 2003; 26: RC9-RC11.
10. Murray C, Kamm M, Bloom S, Emmanuel A. Ghrelin for the gastroenterologist: history and potential. Gastroenter. 2003; 125: 1492-1502.
11. Date Y, Kojima M, Hosoda H, Sawaguchi A, Mondal MS, Suganuma T, Matsukura S, Kangawa K, Nakazato M. Ghrelin, a novel growth hormone-releasing cylated peptide, is synthesied in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans. Endocrinol. 2000; 141: 4255-4261.
12. Wren AM, Small CJ, Ward HL, Murphy KG, Dakin CL, Taheri S, Kennedy AR, Roberts GH, Morgan DG, Ghatei MA, Bloom SR. The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion. Endocrinol. 2000; 141: 4325-4328.
13. Toshinai K, Date Y, Murakami N, Shimada M, Mondal MS, Shimbara T, Guan J, Wang QP, Funahashi H, Sakurai T, Shioda S, Matsukura S, Kangawa K, Nakazato M. Ghrelin-induced food intake is mediated via the orexin pathway. Endocrinol. 2003; 144(4): 1506-1512.
14. Date Y, Murakami N, Kojima M, Kuroiwa T, Matsukura S, Kangawa K, Nakazato M. Central effects of a novel acylated peptide, ghrelin, on growth hormone release in rats. Biochem. Biophys. Res. Commun. 2000; 275: 477-480.
15. Nagaya N, Kojima M, Uematsu M i in. Hemodynamic and hormonal effects of human ghrelin un healthy volunteers. Am. J. Physiol. 2001; 2880: 1483-1487.
16. Cassoni P, Papotti M, Ghe C. Identification, characterization and biological activity of specific receptors for natural (ghrelin) and synthetic growth hormone secretagogues and analogs in human breast carcinomas and cells lines. J. Clin. Endocrinol. Metab. 2001; 86: 1738-1745.
17. Ziegman J, Elmquist. Minireview: From anorexia to obesity - The yin and yang of body weight control. Endocrinol. 2003; 144: 3749-3756.
18. Dornon ville de la Cour C, Bjorkqvist M, Sandvik AK, Bakke I, Zhao CM, Chen D, Hakanson R. A-like cells in the rat stomach contain ghrelin and do not operate under gastrin control. Regul. Pept. 2001; 99: 141-150.
19. Ariyasu H, Takaya K, Tagami T, Ogawa Y, Hosoda K, Akamizu T, Suda M, Koh T, Natsui K, Toyooka S, Shirakami G, Usui T, Shimatsu A, Doi K, Hosoda H, Kojima M, Kangawa K, Nakao K. Stomach is a major source of circulating ghrelin, and feeding state determines plasma ghrelin-like immunoreactivity levels in humans. J Clin Endocrinol Metab. 2001; 86: 4753-4758.
20. Neary NM, Small CJ, Bloom SR. Gut and mind. Gut 2003; 52: 918-921.
21. Guan XM, Yu H, Palyha OC, McKee KK, Feighner SD, Sirinathsinghji DJ, Smith RG, van del Ploeg LH, Howard AD. Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues. Brain Res. Mol. Brain Res. 1997; 48: 23-29.
22. Wren AM, Small CJ, Abbott CR, Dhillo WS, Seal LJ, Cohen MA, Batterham RL, Taheri S, Stanley SA, Ghatei MA, Bloom SR. Ghrelin causes hyperphagia and obesity in rats. Diabetes 2001; 50: 2540-2547.
23. Schwartz MW, Woods SC, Porte Jr D, Seeley RJ, Baskin DG. Central nervous system control of food intake. Nature 2000; 404: 661-671.
24. Kohno D, Gao HZ, Muroya S, Kikuyama S, Yada T. Ghrelin directly interacts with neuropeptide-Y - containing neurons in the rat arcuate nucleus. Diabetes 2003; 52: 948-956.
25. Shintani M, Ogawa Y, Ebihara K, Aizawa-Abe M, Miyanaga F, Takaya K, Hayashi T, Inoue G Hosoda K, Kojima M, Kangawa K, Nakao K. Ghrelin, an endogenous growth hormone secretagogue, is a novel orexigenic peptide that antagonizes leptin action through the activation of hypothalamic neuropeptide Y/YI receptor pathway. Diabetes 2001; 50: 227-232.
26. Nakazato M, Murakami N, Date Y, Kojima M, Matsuo H, Kangawa K, Matsukura S. A role for ghrelin in the central regulation of feeding. Nature 2001; 409: 194-198.
27. de Lecea L, Kilduff TS, Gao XB, Foye PE, Danielson PE, Fukuhara C, Battenberg ELF, Gautvik VT, Bartlett II FS, Frankel WN, van den Pol AN, Bloom FE, Gautvik KM, Sutcliffe JG. The hypocretins: hypothalamus specific peptides with neuroexcitatory activity. Proc. Nat. Acad. Sc. USA 1998; 95: 322-327.
28. Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, Williams SC, Richardson JA, Kozlowski GP, Wilson S, Arch JRS, Buckingham RE, Haynes AC, Carr SA, Annan RS, McNulty DE, Liu WS, Terrett JA, Elshourbagy NA, Bergsma DJ, Yanagisawa M. Orexins and orexin receptor: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 1998; 92: 573-585.
29. Date Y, Ueta Y, Yamashita H, Yamaguchi H, Matsukura S, Kangawa K, Sakurai T, Yanagisawa M, Nakazato M. Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems. Proc. Nat. Acad. Sc. USA 1999; 96: 748-753.
30. Elias CF, Aschkenasi C, Lee C, Kelly J, Ahima RS, Bjorbaek C, Flier JS, Saper CB, Elmquist JK. Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area. Neuron 1999; 23: 775-786.
31. Traebert M, Riediger T, Whitebread S, Scharrer E, Schmid HA. Ghrelin acts on leptin-responsive neurones in the rat arcuate nucleus. J. Neuroendocrinol. 2002; 14: 580-586.
32. Grill HJ, Schwartz MW, Kaplan JM, Foxhall JS, Breininger J, Baskin DG. Evidence that thhe caudal brainstem is a target for the inhibitory effect of leptin on food intake. Endocrinol. 2002, 143: 239-246.
33. Monteleone P, Bencivenga R, Longobardi N, Serritella C, Maj M. Differential responses of circulating ghrelin to high-fat or high-carbohydrate meal in healthy women. J. Clin. Endocrinol. Metab. 2003; 88: 5510-5514.
34. Broglio F, Arvat E, Benso A, Gottero C, Muccioli G, Papotti M, Van der Lely AJ, Deghenghi R, Ghigo E. Ghrelin, a natural GH secretagogue produced by stomach, induces hyperglicemia and reduces insulin secretion in humans. J. Clin. Endocrinol. Metab. 2001; 86: 5083-5086.
35. Asakawa A, Inui A, Kaga T, Yuzuiha H, Nagata T, Ueno N, Makino S, Fujimiya M, Niijima A, Fujino MA, Kasuga M. Ghrelin is an appetite-stimulatory signal from stomach wih structural resamblances to motilin. Gastoenterol. 2001; 120: 337-345.
36. Lawrence CB, Snape AC, Baudoin FM, Luckman SM. Acute central ghrelin and Gh secretagogues induce feeding and activate brain appetite centers. Endocrinol. 2002, 143: 155-162.
37. Tschop M, Weyer C, Tataranni PA, Devanarayan V, Ravussin E, Heiman ML. Circulating ghrelin levels are decreased in human obesity. Diabetes 2001; 50: 707-709.
38. Cummings DE, Purnell JQ, Frayo RS, Scchmidova K, Wisse BE, Weigle DS. A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes 2001; 50: 1714-1719.
39. Toole V, Kadem M, Bluet-Pajot MT, Frere D, Foulon C, Bossu C, Dardennes R, Mounier C, Zizzari P, Lang F, Epelbaum J, Estour B. Balance in ghrelin and leptin levels in anorexia nervosa patients and constitutionally thin women. J. Clin. Endocrinol. Metab. 2003; 88: 109-116.
40. Lee HM, Wang G, Englander EW, Kojima M, Greeley GH. Ghrelin, a new gastrointestinal endocrine peptide that stimulates insulin secretion: enteric distribution, ontogeny, influence of endocrine, and dietary manipulations. Endocrinol. 2002; 143: 185-190.
41. Caxias A, Bashore C, Nash W, Pi-Sunyer F, Laferrere B. Insulin, unlike food intake, does not suppress ghrelin in humans subjects. J. Clin. Endocrinol. Metab. 2002; 87: 1902-1906.
42. Tanaka M, Naruo T, Yasuhara D, Tatebe Y, Nagai N, Shiiya T, Nakazato M, Matsukura S, Nozoe S. Fasting plasma ghrelin levels in subtypes of anorexia nervosa. Psychoneuroendocrinol. 2003; 28: 829-835.
43. Nedvidkova J, Krykorkova I, Bratak V, Papezova H, Gold PW, Alesci S, Pacak K. Loss of meal-induced decrease in plasma ghrelin levels in patients with anorexia nervosa. J. Clin. Endocrinol. Metab. 2003; 88: 1678-1682.
44. Cummings DE, Weigle DS, Frayo RS, Breen PA, Ma MK, Dellinger EP, Purnell JQ. Plasma ghrelin levels after diet-induced wieght loss or gastric bypass. N. Engl. J. Med. 2002; 346: 1623-1630.