T(h)1 cytokines are produced in labial salivary glands in Sjogren's syndrome, but also in healthy individuals

Scandinavian Journal of Rheumatology

Volumn 28, Issue 2, 1999, Pages 106-112

  Konttinen, Yrjö T ^a   Kemppinen, Pertti ^a   Koski, Hannele ^a   Li, Tian Fang ^a   Jumppanen, Mari ^a   Hietanen, Jarkko ^a   Santavirta, Seppo ^a   Salo, Tuula ^a   Larsson, Åke ^a   Hakala, Markku ^a   Sorsa, Timo ^a  

^a NONE

Author keywords

Cytokines; Labial salivary glands; Sjogren's syndrome; T lymphocytes

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5;

ARTICLE; AUTOIMMUNE DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; HELPER CELL; HUMAN; HUMAN TISSUE; IMMUNOLOGICAL TOLERANCE; LATENT VIRUS INFECTION; LIP; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SALIVARY GLAND; SJOEGREN SYNDROME; T LYMPHOCYTE; VIRUS REACTIVATION;

EID: 0032912422     PISSN: 03009742     EISSN: None     Source Type: Journal    
DOI: 10.1080/030097499442577     Document Type: Article

References (36)

1. 1. Vitali C, Bombardieri S, Moutsopoulos HM, Balestrieri G, Bencivelli W, Bernstein RM, Bjerrum K, Braga S, Coll J, De Vita S, Drosos A, Ehrenfeld M, Hatron P, Hay E, Isenberg D, Janin A, Kalden J, Kater L, Konttinen Y, Maddison P, Maini R, Manthorpe R, Meyer O, Ostuni P, Pennec Y, Prause J, Richards A, Sauvezie B, Schiodt M, Sciuto M, Scully C, Schoenfeld Y, Scopouli F, Smolen J, Snaith M, Tishler M, Todescos S, Valesini G, Venables P, Wattiaux M, Youinou P. Preliminary criteria for the classification of Sjögren's syndrome. Results of a prospective concerted action supported by the European Community. Arthritis Rheum 1993;36:340-7.
2. 2. Konttinen YT. In situ characterization of the cellular infiltrate in labial and palatine glands in Sjögren's syndrome. Scand J Rheumatol 1981;10:321-30.
3. 3. Fox RI, Carstens S, Fong S, Robinson CA, Howell F, Vaughan JH. Use of monoclonal antibodies to analyze peripheral blood and salivary gland lymphocyte subsets in Sjögren's syndrome. Arthritis Rheum 1982;25:419-26.
4. 4. Talal N, Sylvester RA, Daniels TE, Greenspan JS, Williams RC Jr. T and B lymphocytes in peripheral blood and tissue lesions in Sjögren's syndrome. J Clin Invest 1974;53:180-9.
5. 5. Jonsson R, Halse A.-K, Kroneld U, Wahren M. Spontaneous local and peripheral secretion of immunoglobulins and anti-Ro/SSA autoantibody in Sjögren's syndrome (abstract). Clin Rheumalol 1995;14 Suppl 1:35.
6. 6. Fox RI, Kang HI. Pathogenesis of Sjögren's syndrome. Rheum Dis Clin North Am 1992;18:517-38.
7. 7. Mosmann TR, Sad S. The expanding universe of T-cell subsets: Th1, Th2 and more. Immunol Today 1996;17:138-46.
8. 8. Fox RI, Kang HI, Ando D, Abrams J, Pisa E. Cytokine mRNA expression in salivary gland biopsies of Sjögren's syndrome. J Immunol 1994;152;5532-9.
9. 9. Boumba D, Skopouli FN, Moutsopoulos HM. Cytokine mRNA expression in the labial salivary gland tissues from patients with Sjögren's syndrome. Brit J Rheumatol 1995; 34:326-33.
10. 10. Ogawa N, Dang H, Lazaridis K, McGuff HS, Aufdemorte TB, Talal N. Analysis of transforming growth factor beta and other cytokines in autoimmune exocrinopathy (Sjögren's syndrome). J Interferon Cytokine Res 1995;15:759-67.
11. 11. Ohyama Y, Nakamura S, Matsuzaki G, Shinohara M, Hiroki A, Fujimura T. Cytokine messenger RNA expression in the labial salivary glands of patients with Sjögren's syndrome. Arthritis Rheum 1996;39:1376-84.
12. 12. Declaration of Helsinki, Hong Kong Amendment, September, 1989.
13. R. Scand J Rheumatol 1988;17:77-86.
14. 14. Konttinen YT, Törnwall J, Kemppinen P, Uusitalo H, Sorsa T, Hukkanen M. Neutral endopeptidase (EC 3.4.24.11) in labial salivary glands in healthy controls and in Sjögren's syndrome. Ann Rheum Dis 1996;55:513-9.
15. 15. Sander B, Hoiden I, Andersson U, Moller E, Abrams JS. Similar frequencies and kinetics of cytokine producing cells in murine peripheral blood and spleen. Cytokine detection by immunoassay and intracellular immunostaining. J Immunol Methods 1993;166:201-14.
16. 16. Andersson J, Abrams J, Bjork L, Funa K, Litton M, Agren K, Andersson U. Concomitant in vivo production of 19 different cytokines in human tonils. Immunology 1994;83:16-24.
17. 17. Andersson J, Andersson U. Characterization of cytokine production in infectious mononucleosis studied at a single-cell level in tonsil and peripheral blood. Clin Exp Immunol 1993;92:7-13.
18. 18. Saito I, Terauchi K, Shimuta M, Nishiimura S, Yoshino K, Takeuchi T, Tsubota K, Miyasaka N. Expression of cell adhesion molecules in the salivary and lacrimal glands of Sjögren's syndrome. J Clin Lab Anal 1993;7:180-7.
19. 19. Segerberg-Konttinen M, Bergroth V, Jungell P, Malmström M, Nordström D, Sane J, Immonen I, Nordström D, Konttinen YT. T lymphocyte activation state in the minor salivary glands of patients with Sjögren's syndrome. Ann Rheum Dis 1987;46:649-53.
20. 20. Fox RI, Theofilopoulos AN, Altman A. Production of interleukin 2 (IL 2) by salivary gland lymphocytes in Sjögren's syndrome. Detection of reactive cells by using antibody directed to synthetic peptides of IL 2. J Immunol 1985b;135;3109-15.
21. 21. Assenmacher M, Schmitz J, Radbruch A. Flow cytometric determination of cytokines in activated murine T helper lymphocytes: expression of interleukin-10 in interferon-gamma and in interleukin-4-expressing cells. Eur J Immunol 1994; 24:1097-101.
22. 22. Bucy RP, Karr L, Huang GQ, Li J, Carter D, Honjo K, Lemons J, Murphy K, Weaver C. Single cell analysis of cytokine gene coexpression during CD4+ T-cell phenotype development. Proc Natl Acad Sci USA 1995;92:7565-9.
23. 23. Fox RI, Hugli TE, Lanier LL, Morgan FL, Howell F. Salivary gland lymphocytes in primary Sjögren's syndrome lack lymphocyte subsets defined by Leu-7 and Leu-11 antigens. J Immunol 1985a;135:207-14.
24. 24. Terada K, Katamine S, Eguchi K, Moriuchi R, Kita M, Shimada H, et al. Prevalence of serum and salivary antibodies to HTLV-1 in Sjögren's syndrome. Lancet 1994;344:1116-9.
25. 25. Jorgensen C, Legouffe MC, Perney P, Coste J, Tissot B, Segarra C, et al. Sicca syndrome associated with hepatitis C virus infection. Arthritis Rheum 1996;39:1166-71.
26. 26. Talal N, Dauphinee MJ, Dang H, Garry RF, Seibold JR, Medsger TA Jr, et al. Detection of serum antibodies to retroviral proteins in patients with primary Sjören's syndrome (autoimmune exocrinopathy). Arthritis Rheum 1990;33: 774-81.
27. 27. Hasler F, Bluestein HG, Zvaifler NJ, Epstein LB. Analysis of the defects responsible for the impaired regulation of Epstein-Barr virus-induced B cell proliferation by rheumatoid arthritis lymphocytes. I. Diminished gamma interferon production in response to autologous stimulation. J Exp Med 1983;157: 173-88.
28. 28. Konttinen YT, Bluestein HG, Zvaifler NJ. Regulation of the growth of Epstein-Barr virus infected B cells. I. Growth regression by E-rosetting cells from VCA-positive donors is a combined effect of autologous mixed leukocyte reaction and activation of T8 memory cells. J Immunol 1985;134:2287-93.
29. 29. Bottazzo GF, Pujol-Borrell R, Hanafusa T, Feldmann M. Role of aberrant HLA-DR expression and antigen presentation in induction of endocrine autoimmunity. Lancet 1983;2:1115-9.
30. 30. Mircheff AK, Gierow JP, Wood RL. Traffic of major histocompatibility complex class II molecules in rabbit lacrimal gland acinar cells. Invest Ophthal Vis Sci 1994;35:3943-51.
31. 31. Yang T, Gierow JP, Wood RL. MHC class II molecules, cathepsin B, and secretory products in endomembranes of lacrimal gland acinar cells (abstract). Clin Rheumatol 1995;14 Suppl 1:30.
32. 32. Lindahl G, Hedfors E. Lymphocytic infiltrates and epithelial HLA DR expression in lip salivary glands in connective tissue disease patients lacking sicca: a prospective study. Brit J Rheumatol 1989;28:293-8.
33. 33. Dolhain RJ, Andersson U, ter Haar NT, Brinkman UM, Verweij CL, Daha MR, Breedveld FC, Millenburg AM. Deteclion of intracellular interferon-gamma by light microscopy using an immunoperoxidase technique: correlation with the corresponding mRNA and protein product. J Leukocyte Biol 1993;54:545-51.
34. 34. Raqib R, Ljungdahl A, Lindberg AA, Wretlind B, Andersson U, Andersson J. Dissociation between cytokine mRNA expression and protein production in shigellosis. Eur J Immunol 1996;26:1130-8.
35. 35. Peszkowski M, Fujiwara K, Warfvinge G, Larsson A. Experimental graft versus host disease in the (BnxLEW)F1 rat hybrid as a model for autoimmune disease. Study of early adenitis in lacrimal and salivary glands. Oral Dis 1996;2:2-10.
36. 36. de Vita S, Dolcetti R, Ferraccioli G, Pivetta B, de Re V, Gloghini A, D'Agosto A, Bartoli E, Carbone A, Boiocchi M. Local cytokine expression in the progression toward B cell malignancy in Sjögren's syndrome. J Rheum 1995;22:1674-80.