Effect of herbal melanin on IL-8: A possible role of Toll-like receptor 4 (TLR4)

Biochemical and Biophysical Research Communications

Volumn 344, Issue 4, 2006, Pages 1200-1206

  El Obeid, Adila ^a   Hassib, Adil ^b   Pontén, Fredrik ^a   Westermark, Bengt ^a  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^b KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

CD14; Herbal melanin; IL 8; Lipopolysaccharide; MD2; Nigella sativa L; Toll like receptor 4

Indexed keywords

CD14 ANTIGEN; HERBAL MELANIN EXTRACT; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; MESSENGER RNA; PLANT EXTRACT; PROTEIN MD 2; TOLL LIKE RECEPTOR 4; UNCLASSIFIED DRUG;

ARTICLE; BLACK CUMIN; CELL LINE; CELL STRAIN HEK293; CONTROLLED STUDY; CYTOKINE PRODUCTION; HUMAN; HUMAN CELL; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION;

CELLS, CULTURED; HUMANS; INTERLEUKIN-8; LEUKOCYTES, MONONUCLEAR; LIPOPOLYSACCHARIDES; MELANINS; PLANT EXTRACTS; RNA, MESSENGER; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4;

NIGELLA SATIVA;

EID: 33646203334     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2006.04.035     Document Type: Article

References (49)

1. Stinchcombe J., Bossi G., and Griffiths G.M. Linking albinism and immunity: the secrets of secretory lysosomes. Science 305 (2004) 55-59
2. Fedorow H., Halliday G.M., Rickert C.H., Gerlach M., Riederer P., and Double K.L. Evidence for specific phases in the development of human neuromelanin. Neurobiol. Aging 27 (2006) 506-512
3. Pathak M.A. Functions of melanin and protection by melanin. In: Zeise L., Chedekel M.R., and Fitzpatrick T.B. (Eds). Melanin: Its Role in Human Photoprotection (1995), American Society for Photobiology, Valdenmar Publishing Co, Overland Park, KS 125-140
4. Riley P.A. Melanin. Int. J. Biochem. Cell Biol. 29 (1997) 1235-1239
5. Prota G. Progress in the chemistry of melanins and related metabolites. Med. Res. Rev. 8 (1988) 525-556
6. Pezzella A., d'Ischia M., Napolitano A., Palumbo A., and Prota G. An integrated approach to the structure of sepia melanin. Evidence for a high proportion of degraded 5,6-dihydroxyindole-2-carboxylic acid units in the pigment backbone. Tetrahedron 53 (1977) 8281-8286
7. Zeise L. Analytical methods for characterization and identification of eumelanins. In: Zeise L., Chedekel M.R., and Fitzpatrick T.B. (Eds). Melanin: Its Role in Human Photoprotection (1995), Valdenmar Publishing, Overland Park, KS 65-79
8. Buszman E., Kopera M., and Wilczok T. Electron spin resonance studies of chloroquine-melanin complexes. Biochem. Pharmacol. 33 (1984) 7-11
9. Sava V.M., Yang S.M., Hong M.Y., Yang P.C., and Huang G.S. Isolation and characterization of melanic pigments derived from tea and tea polyphenols. Food Chem. 73 (2001) 177-184
10. A. Hassib, Extraction of melanin from Nigella sativa L., Patent No. 451, Khartoum, Sudan, 1998.
11. Kawai T., and Akira S. Pathogen recognition with Toll-like receptors. Curr. Opin. Immunol. 17 (2005) 338-344 Review
12. Takeda K., and Akira S. Toll-like receptors in innate immunity. Int. Immunol. 17 (2005) 1-14 Review
13. Medzhitov R., Preston-Hurlburt P., and Janeway Jr. C.A. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 388 (1997) 394-397
14. Uehori J., Matsumoto M., Tsuji S., Akazawa T., Takeuchi O., Akira S., Kawata T., Azuma I., Toyoshima K., and Seya T. Simultaneous blocking of human Toll-like receptors 2 and 4 suppresses myeloid dendritic cell activation induced by Mycobacterium bovis bacillus Calmette-Guerin peptidoglycan. Infect. Immun. 71 (2003) 4238-4249
15. Bauer S., Kirschning C.J., Hacker H., Redecke V., Hausmann S., Akira S., Wagner H., and Lipford G.B. Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition. Proc. Natl. Acad. Sci. USA 98 (2001) 9237-9242
16. Poltorak A., He X., Smirnova I., Liu M.Y., Van Huffel C., Du X., Birdwell D., Alejos E., Silva M., Galanos C., Freudenberg M., Ricciardi-Castagnoli P., Layton B., and Beutler B. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282 (1998) 2058-2085
17. Beutler B. Tlr4: central component of the sole mammalian LPS sensor. Curr. Opin. Immunol. 12 1 (2000) 20-26 Review
18. Freudenberg M.A., and Galanos C. Bacterial lipopolysaccharides: structure, metabolism and mechanisms of action. Int. Rev. Immunol. 6 (1990) 207-221
19. Raetz C.R., Ulevitch R.J., Wright S.D., Sibley C.H., Ding A., and Nathan C.F. Gram-negative endotoxin: an extraordinary lipid with profound effects on eukaryotic signal transduction. FASEB J. 5 (1991) 2652-2660 Review
20. Pugh N.D., Balachandran P., Lata H., Dayan F.E., Joshi V., Bedir E., Makino T., Moraes R., Khan I., and Pasco D.S. Melanin: dietary mucosal immune modulator from Echinacea and other botanical supplements. Int. Immunopharmacol. 5 (2005) 637-647
21. A. El-Obeid, S. Al-Harbi, N. Al-Jomah, A. Hassib, Herbal melanin modulates tumor necrosis factor alpha (TNF-a), interleukin 6 (IL-6) and vascular endothelial growth (VEGF) production, Phytomedicine, in press.
22. Yoshimura T., Matsushima K., Tanaka S., Robinson E.A., Appella E., Oppenheim J.J., and Leonard E.J. Purification of a human monocyte-derived neutrophil chemotactic factor that has peptide sequence similarity to other host defense cytokines. Proc. Natl. Acad. Sci. USA 84 (1987) 9233-9237
23. Jack R.S., Fan X., Bernheiden M., Rune G., Ehlers M., Weber A., Kirsch G., Mentel R., Furll B., Freudenberg M., Schmitz G., Stelter F., and Schutt C. Lipopolysaccharide-binding protein is required to combat a murine Gram-negative bacterial infection. Nature 389 (1997) 742-745
24. Frey E.A., Miller D.S., Jahr T.G., Sundan A., Bazil V., Espevik T., Finlay B.B., and Wright S.D. Soluble CD14 participates in the response of cells to lipopolysaccharide. J. Exp. Med. 176 (1999) 1665-1671
25. Shimazu R., Akashi S., Ogata H., Nagai Y., Fukudome K., Miyake K., and Kimoto M. MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4. J. Exp. Med. 189 (1999) 1777-1782
26. El-Obeid A., Sunnuqrut N., Hussain A., Al-Hussein K., Gutierrez M.I., and Bhatia K. Immature B cell malignancies synthesize VEGF, VEGFR-1 (Flt-1) and VEGFR-2 (KDR). Leuk. Res. 28 (2004) 133-137
27. Antonicelli F., Brown D., Parmentier M., Drost E.M., Hirani N., Rahman I., Donaldson K., and MacNee W. Regulation of LPS-mediated inflammation in vivo and in vitro by the thiol antioxidant Nacystelyn. Am. J. Physiol. Lung Cell. Mol. Physiol. 286 (2004) L1319-L1327
28. Fitzgerald K.A., Rowe D.C., and Golenbock D.T. Endotoxin recognition and signal transduction by the TLR4/MD2-complex. Microbes Infect. 6 (2004) 1361-1367 Review
29. Latz E., Visintin A., Lien E., Fitzgerald K.A., Monks B.G., Kurt-Jones E.A., Golenbock D.T., and Espevik T. Lipopolysaccharide rapidly traffics to and from the Golgi apparatus with the toll-like receptor 4-MD-2-CD14 complex in a process that is distinct from the initiation of signal transduction. J. Biol. Chem. 277 (2002) 44743-47834
30. Marchand P., Resch K., and Radeke H.H. Selective inhibition of monocyte chemoattractant protein-1 gene expression in human embryonal kidney cells by specific triple helix-forming oligonucleotides. J. Immunol. 164 (2000) 2070-2076
31. Yang H., Young D.W., Gusovsky F., and Chow J.C. Cellular events mediated by lipopolysaccharide-stimulated toll-like receptor 4. MD-2 is required for activation of mitogen-activated protein kinases and Elk-1. J. Biol. Chem. 275 (2000) 20861-20869
32. Visintin A., Latz E., Monks B.G., Espevik T., and Golenbock D.T. Lysines 128 and 132 enable lipopolysaccharide binding to MD-2, leading to Toll-like receptor-4 aggregation and signal transduction. J. Biol. Chem. 278 48 (2003) 48313-48320 Epub 2003 Sep 5
33. Re F., and Strominger J.L. Monomeric recombinant MD-2 binds toll-like receptor 4 tightly and confers lipopolysaccharide responsiveness. J. Biol. Chem. 277 (2002) 23427-23432
34. Kawasaki K., Nogawa H., and Nishijima M. Identification of mouse MD-2 residues important for forming the cell surface TLR4-MD-2 complex recognized by anti-TLR4-MD-2 antibodies, and for conferring LPS and taxol responsiveness on mouse TLR4 by alanine-scanning mutagenesis. J. Immunol. 170 (2003) 413-420
35. Nishitani C., Mitsuzawa H., Hyakushima N., Sano H., Matsushima N., and Kuroki Y. The Toll-like receptor 4 region Glu24-Pro34 is critical for interaction with MD-2. Biochem. Biophys. Res. Commun. 328 (2005) 586-590
36. Duenas A.I., Orduna A., Crespo M.S., and Garcia-Rodriguez C. Interaction of endotoxins with Toll-like receptor 4 correlates with their endotoxic potential and may explain the proinflammatory effect of Brucella spp. LPS. Int. Immunol. 16 (2004) 1467-1475
37. Haq A., Lobo P., Al-Tufail M., Rama N., and Al-Sedairy S. Immunomodulatory effect of Nigella sativa proteins fractionated by ion exchange chromatography. Int. J. Immunopharmacol. 21 (1999) 283-295
38. Salem M.L. Immunomodulatory and therapeutic properties of the Nigella sativa L. seed. Int. Immunopharmacol. 5 (2005) 1749-1770
39. Yang S., Tamai R., Akashi S., Takeuchi O., Akira S., sugawara S., and Takada H. Synergistic effect of muramyldipeptide with lipopolysaccharide or lipoteichoic acid to induce inflammatory cytokines in human monocytic cells in culture. Infect. Immun. 69 (2001) 2045-2053
40. Hijiya N., Miyake K., Akashi S., Matsuura K., Higuchi Y., and Yamamoto S. Possible involvement of Toll-like receptor 4 in endothelial cell activation of larger vessels in response to lipopolysaccharide. Pathobiology 70 (2002) 18-25
41. Song M., and Phelps D.S. Comparison of SP-A and LPS effects on the THP-1 monocytic cell line. Am. J. Physiol. Lung Cell Mol. Physiol. 279 (2000) L110-L117
42. JEggesbo J.B., Hjermann I., Lund P.K., Joo G.B., Ovstebo R., and Kierulf P. LPS-induced release of IL-1 beta, IL-6, IL-8, TNF-alpha and sCD14 in whole blood and PBMC from persons with high or low levels of HDL-lipoprotein. Cytokine 6 (1994) 521-529
43. Tamai R., Asai Y., Hashimoto M., Fukase K., Kusumoto S., Ishida H., Kiso M., and Ogawa T. Cell activation by monosaccharide lipid A analogues utilizing Toll-like receptor 4. Immunology 110 (2003) 66-72
44. Tamai R., Sugawara S., Takeuchi O., Akira S., and Takada H. Synergistic effects of lipopolysaccharide and interferon-in inducing interleukin-8 production in human monocytic THP-1 cells is accompanied by up-regulation of CD14, Toll-like receptor 4, MD-2 and MyD88 expression. J. Endotoxin Res. 9 (2003) 145-153
45. Akashi S., Saitoh S., Wakabyshi Y., Kikuchi T., Takamura N., Nagai Y., Kusumoto Y., Fukase K., Kusumoto S., Adachi Y., Kosugi A., and Miyake K. Lipopolysaccharide interaction with cell surface Toll-like receptor 4-MD-2 or CD14. J. Exp. Med. 198 (2003) 1035-1042
46. Akashi S., Nagai Y., Ogata H., Oikawa M., Fukase K., Kusumoto S., Kawasaki K., Nishijima M., Hayashi S., Kimoto M., and Miyake K. Human MD-2 confers on mouse Toll-like receptor 4 species-specific lipopolysaccharide recognition. Int. Immunol. 13 (2001) 1595-1599
47. Heine H., Muller-Loennies S., Brade L., Lindner B., and Brade H. Endotoxic activity and chemical structure of lipopolysaccharides from Chlamydia trachomatis serotypes E and L2 and Chlamydophila psittaci 6BC. Eur. J. Biochem. 270 (2003) 440-450
48. Azuma I., and Seya T. Development of immunoadjuvants for immunotherapy of cancer. Int. Immunopharmacol. 7 (2001) 1249-1259 Review
49. Tsuji S., Matsumoto M., Takeuchi O., Akira S., Azuma I., Hayashi A., Toyoshima K., and Seya T. Maturation of human dendritic cells by cell wall skeleton of Mycobacterium bovis bacillus Calmette-Guerin: involvement of toll-like receptors. Infect. Immun. 68 (2000) 6883-6890