Tumor suppressor activity of ODC antizyme in MEK-driven skin tumorigenesis

Carcinogenesis

Volumn 27, Issue 5, 2006, Pages 1090-1098

  Feith, David J ^a   Origanti, Sofia ^a   Shoop, Paula L ^a   Sass Kuhn, Suzanne ^a   Shantz, Lisa M ^a  

^a PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; ORNITHINE DECARBOXYLASE; PUTRESCINE; RAF PROTEIN; SPERMIDINE; SPERMINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER INCIDENCE; CARCINOGENESIS; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME DEGRADATION; FEMALE; GENE OVEREXPRESSION; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; MALE; MITOSIS; MOUSE; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; SKIN TUMOR; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; TUMOR DIFFERENTIATION;

ANIMALS; CELL CYCLE; CELL PROLIFERATION; MAP KINASE KINASE KINASES; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; MICE, INBRED ICR; MICE, TRANSGENIC; MUTATION; PROTEINS; PUTRESCINE; SKIN NEOPLASMS; TRANSGENES;

EID: 33646182729     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgi343     Document Type: Article

References (50)

1. Perez-Losada,J. and Balmain,A. (2003) Stem-cell hierarchy in skin cancer. Nat. Rev. Cancer, 3, 434-443.
2. Arbeit,J. (1996) Transgenic models of epidermal neoplasia and multistage carcinogenesis. Cancer Surv., 26, 7-34.
3. Ravanko,K., Jarvinen,K., Paasinen-Sohns,A. and Hölttä,E. (2000) Loss of p27Kip1 from cyclin E/cyclin-dependent kinase (CDK) 2 but not from cyclin D1/CDK4 complexes in cells transformed by polyamine biosynthetic enzymes. Cancer Res., 60, 5244-5253.
4. Geng,H., Naylor,P.H., Dosecu,J., Skunca,M., Majumdar,A.P.N. and Moshier,J.A. (2000) TGFα is required for full expression of the transformed growth phenotype of NIH 3T3 cells overexpressing ornithine decarboxylase. Carcinogenesis, 21, 567-572.
5. Hölttä,E., Sistonen,L. and Alitalo,K. (1988) The mechanism of ornithine decarboxylase deregulation in c-Ha-ras oncogene-transformed NIH 3T3 cells. J. Biol. Chem., 263, 4500-4507.
6. Hölttä,E., Auvinen,M. and Andersson,L.C. (1993) Polyamines are esential for cell transformation for pp6Ov-src: Delination of molecular events relevant for the transformed phenotype. J. Cell Biol., 122, 903-914.
7. Shantz,L.M. and Pegg,A.E. (1998) Ornithine decarboxylase induction in transformation by H-Ras and RhoA. Cancer Res., 58, 2748-2753.
8. Shantz,L.M. (2004) Transcriptional and translational control of ornithine decarboxylase during Ras transformation. Biochem. J., 377, 257-264.
9. Bello-Fernandez,C., Packham,G. and Cleveland,J.L. (1993) The ornithine decarboxylase gene is a transcriptional target of c-Myc. Proc. Natl Acad. Sci. USA, 90, 7804-7808.
10. Li,R.-S., Law,G.L., Seifert,R.A., Romaniuk,P.J. and Morris,D.R. (1999) Ornithine decarboxylase is a transcriptional target of tumor suppressor WT1. Exp. Cell. Res., 247, 257-266.
11. O'Brien,T.G., Megosh,L.C., Gilliard,G. and Peralta-Soler,A. (1997) Ornithine decarboxylase overexpression is a sufficent condition for tumor promotion in mouse skin. Cancer Res., 57, 2630-2637.
12. Penilta-Soler,A., Gilliard,G., Megosh,L., George,K. and O'Brien,T.G. (1998) Polyamines regulate expression of the neoplastic phenotype in mouse skin. Cancer Res., 58, 1654-1659.
13. Lan,L., Trempus,C. and Gilmour,S.K. (2000) Inhibition of ornithine decarboxylase (ODC) decreases tumor vascularization and reverses spontaneous tumors in ODC/Ras transgenic mice. Cancer Res., 60, 5696-5703.
14. Hayes,C.S., Defeo,K., Lan,L., Paul,B., Sell,C. and Gilmour,S.K. (2005) Elevated levels of ornithine decarboxylase cooperate with Raf/ERK activation to convert normal keratinocytes into invasive malignant cells. Oncogene, Advance Online Publication, 7 Nov, 2005.
15. Feith,D.J., Bol,D.K., Carboni,J., Lynch,M., Sass-Kuhn,S., Shoop,P. and Shantz,L.M. (2005) Induction of ornithine decarboxylase activity is a necessary step for MEK-induced skin tumorigenesis. Cancer Res., 65, 572-578.
16. Shantz,L.M., Guo,Y., Pegg,A.E., Sawicki,J.A. and O'Brien,T.G. (2002) Overexpression of a dominant-negative ornithine decarboxylase mutant in mouse skin: Effect on enzyme activity and papilloma formation. Carcinogenesis, 23, 657-664.
17. Feith,D.J., Shantz,L.M. and Pegg,A.E. (2001) Targeted antizyme expression in the skin of transgenic mice reduces tumor promoter induction of ornithine decarboxylase and decreases sensitivity to chemical carcinogenesis. Cancer Res., 61, 6073-6081.
18. Hayashi,S., Murakami,Y. and Matsufuji,S. (1996) Ornithine decarboxylase antizyme: A novel type of regulatory protein. TIBS, 21, 27-30.
19. Coffino,P. (2001) Regulation of cellular polyamines by antizyme. Nat. Rev. Mol. Cell. Biol., 2, 188-194.
20. +/- mice. J. Clin. Invest., 113, 867-875.
21. Casatorres,J., Navarro,J.M., Blessing,M. and Jorcano,J. (1994) Analysis of the control of expression and tissue specificity of the keratin 5 gene, characteristic of basal keratinocytes. J. Biol. Chem., 269, 20489-20496.
22. Ramirez,A., Vidall,M., Bravo,A.E., Larcher,F. and Jorcano,J. (1995) A 5′-upstream region of a bovine keratin 6 gene confers tissue-specific expression and hyperproliferation-related induction in transgenic mice. Proc. Natl Acad. Sci, 92, 4783-4787.
23. 14C]-ornithine. In Morgan,D.M.L. (ed.), Polyamine Protocols. Humana Press, Totowa, NJ, Vol. 79, pp. 41-44.
24. Pegg,A.E., Wechter,R., Poulin,R., Woster,P.M. and Coward,J.K. (1989) Effect of S-adenosyl-1,12-diamino-3-thio-9-azadodecane, a multisubstrate inhibitor of spermine synthase, on polyamine metabolism in mammalian cells. Biochemistry, 28, 8446-8453.
25. Frank,J.D., Caftwright,M.E. and Keenan,K.P. (1993) Intensification of 5-bromo-2′-deoxyuridine immunohistochemistry with zinc buffered formalin postfixation and ABC Elite solution. J. Histotechnology, 16, 329-334.
26. DiGiovanni,J., Prichett,W.P., Decina,P.C. and Diamond,L. (1984) DBA/2 mice are as sensitive as SENCAR mice to skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate. Carcinogenesis, 5, 1493-1498.
27. Naito,M., Chenicek,K.J., Naito,Y. and DiGiovanni,J. (1988) Suseptibility to phorbol ester skin tumor promotion in (C57BL/6 x DBA/2) F1 mice is inherited as an incomplete dominant trait: Evidence for multi-locus involvement. Carcinogenesis, 9, 639-645.
28. Fuchs,E. (1995) Keratins and the skin. Ann. Rev. Cell Dev. Biol., 11, 123-153.
29. Brown,K., Strathdee,D., Bryson,S., Lambie,W. and Balmain,A. (1998) The malignant capacity of skin tumors induced by expression of a mutant H-ras transgene depends on the cell type targeted. Current Biol., 8, 516-524.
30. Smith,M.K., Trempus,C.S. and Gilmour,S.K. (1998) Co-operation between follicular ornithine decarboxylase and v-Ha-ras induces spontaneous papillomas and malignant conversion in transgenic skin. Carcinogenesis, 19, 1409-1415.
31. Dietrich,D.R. (1994) Toxicological and pathological applications of proliferating cell nuclear antigen (PCNA), a novel endogenous marker for cell proliferation. Crit. Rev. Toxicol., 23, 77-109.
32. Siegel,P.M., Shu,W., Cardiff,R.D., Muller,W.J. and Massague,J. (2003) Transforming growth factor β signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis. Proc. Natl Acad. Sci., 100, 8430-8435.
33. Koza,R.A., Megosh,L.C. and O'Brien,T.G. (1991) Constitutively elevated levels of ornithine and polyamines in mouse epidermal papillomas. Carcinognesis (London), 12, 1619-1625.
34. O'Brien,T.G. (1976) The induction of ornithine decarboxylase is an early, possibly obligatory event in mouse skin carcinogenesis. Cancer Res., 36, 2644-2653.
35. Grasl-Krauupp,B., Ruttkay-Nedecky,B., Koudelka,H., Bukowska,K., Bursch,W. and Schulte-Hermann,R. (1995) In situ detection of fragmented DNA (TUNEL assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: A cautionary note. Hepatology, 21, 1465-1468.
36. Angel,J.M., Beltran,L., Minda,F., Rupp,T. and DiGiovanni,J. (1997) Association of a murine chromosome locus (Ps11) with susceptibility to mouse skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate. Mol. Carcinog., 20, 162-167.
37. Nagase,H., Bryson,S., Cordell,H., Kemp,C.J., Fee,F. and Balmain,A. (1995) Distinct genetic loci control development of benign and malignant skin tumors in mice. Nat. Genet., 10, 424-429.
38. Megosh,L.C., Hu,J., George,K. and O'Brien,T.G. (2002) Genetic control of polyamine-dependent susceptibility to skin tumorigenesis. Genomics, 79, 505-512.
39. Guo,Y., Cleveland,J.L. and O'Brien,T.G. (2005) Haploinsufficiency for odc modifies mouse skin tumor susceptibility. Cancer Res., 65, 1146-1149.
40. 1-acetyltransferase increases susceptibility to chemically-induced skin carcinogenesis. Carcinogenesis, 23, 359-364.
41. Fredlund,J.O., Johansson,M.C., Dahlberg,E. and Oredsson,S.M. (1995) Ornithine decarboxylase and S-adenosylmethionine decarboxylase expression during the cell cycle of Chinese hamster ovary cells. Exp. Cell Res., 216, 86-92.
42. 1/S transition and prolonged S phase within one cell cycle after seeding cells in the presence of an ornithine decarboxylase inhibitor. Cell Prolif., 29, 457-465.
43. Pyronnet,S., Pradayrol,L. and Sonenberg,N. (2000) A cell cycle-dependent internal ribosome entry site. Mol. Cell, 5, 607-616.
44. Oredsson,S.M. (2003) Polyamine dependence of normal cell-cycle progression. Biochem Soc. Trans., 31, 366-370.
45. Gruendler,C., Lin,Y., Farley,J. and Wang,T. (2001) Proteasomal degradation of Smad1 induced by bone morphogenetic proteins. J. Biol. Chem, 276,46533-46543.
46. Newman,R.M., Mobascher,A., Mangold,U., Koike,C., Diah,S., Schmidt,M., Finley,D. and Zetter,B.R. (2004) Antizyme targets cyclin D1 for degradation: A novel mechanism for cell growth repression. J. Biol. Chem, 279, 41504-41511.
47. Fong,L.Y., Feith,D.J. and Pegg,A.E. (2003) Antizyme overexpression in transgenic mice reduces cell proliferation, increases apoptosis, and reduces N-nitrosomethylbenzylamine-induced forestomach carcinogenesis. Cancer Res., 63, 3945-3954.
48. Gandarillas,A. (2000) Epidermal differentiation, apoptosis, and senescence: Common pathways? Exp. Gerontol., 35, 53-62.
49. Arbeit,J.M., Riley,R.R., Huey,B., Porter,C., Kellof,G., Lubet,R., Ward,J.M. and Pinkel,D. (1999) Difluoromethylornithine chemoprevention of epidermal carcinogenesis in K14-HPV16 transgenic mice. Cancer Res., 59, 3610-3620.
50. Wheeler D.L., Ness,K.J., Oberley,T.D. and Verma,A.K. (2003) Inhibition of development of metastatic squamous cell carcinoma in protein kinase C ε transgenic mice by α-difluoromethylornithine accompanied by marked hair follicle degeneration and hair loss. Cancer Res., 63, 3037-3042.